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Primary lip repair reduces anterior cleft width by 6.217 mm and curvature angle by 14.66 degreesPrimary lip repair improves width and curvature in cleft cases

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Key Takeaway
Note that primary lip repair reduces anterior cleft width and curvature angle, though evidence certainty is very low.

This meta-analysis evaluated outcomes for 265 children with unilateral cleft lip and palate (UCLP) following primary lip repair. The study focused on two primary anatomical metrics: anterior cleft width (CW) and anterior curvature angle (ACA).

The analysis reported a mean difference of -6.217 mm for CW (95% CI: -7.230 to -5.204; p <.001) and a mean difference of -14.66 degrees for ACA (95% CI: -19.62 to -9.7). Additionally, initial cleft width was identified as a significant predictor of CW change (beta = -0.842; p =.002), while follow-up duration showed a borderline association with CW change (beta = -0.387; p =.051).

The authors noted substantial heterogeneity for both CW (I2 = 81.8%) and ACA (I2 = 88.1%), alongside small sample sizes in some cohorts. Consequently, the GRADE approach assigned a very low certainty of evidence to both primary outcomes. These findings are exploratory; while they may support early treatment planning, results should be interpreted with caution due to high heterogeneity.

How this fits prior evidence

This meta-analysis addresses gaps in understanding anatomical changes following primary lip repair for children with unilateral cleft lip and palate. While previous coverage noted that operating microscope use increased operative time but maintained similar complication rates in cleft palate repair, this study focuses on the specific dimensional improvements of the initial repair. The findings regarding reduction in width and curvature are exploratory due to high heterogeneity.

When a child is born with a cleft lip and palate, early surgical repairs are vital for their development. A review of 265 children helped researchers look closer at how these initial surgeries change the shape of the lip over time. The study focused on two main measurements: the width of the front part of the lip and the angle of its curve.

The results showed that primary repair significantly reduced both the width of the gap and the curvature angle. Specifically, the width decreased by about 6.2 millimeters, while the curvature angle improved by roughly 14 degrees. The data also suggested that the original size of the cleft was a strong predictor of how much the width would change after surgery.

While these results are promising for planning early treatments, it is important to note that the evidence comes from small groups and varied studies. Because the findings are exploratory and have low certainty, doctors should use this information as one piece of the puzzle when planning care for children.

What this means for you:
Initial lip surgery significantly reduces cleft width and improves curvature in children with a cleft lip and palate.

Common questions

How much does surgery change the shape of the lip?

The study found that primary lip repair led to a significant reduction in the width of the front part of the lip by about 6.217 millimeters. It also significantly improved the curvature angle of the lip by about 14.66 degrees.

Does the original size of the cleft affect how well surgery works?

Yes, the study found that the initial width of the cleft was a significant predictor of how much the width would change after the repair. This suggests that the starting size helps predict post-surgery results.

How certain are these findings for medical planning?

The evidence is currently considered to have very low certainty because the studies involved small groups and had a lot of variation. These results should be viewed as exploratory data rather than a definitive rule.

Study Details

Study typeMeta analysis
Sample sizen = 265
EvidenceLevel 1
PublishedAug 2026
View Original Abstract ↓
ObjectiveThis systematic review and meta-analysis aimed to quantify morphological changes in the anterior maxillary arch-specifically anterior cleft width (CW) and anterior curvature angle (ACA)-following primary lip repair in children with unilateral cleft lip and palate (UCLP).MethodsA comprehensive search of PubMed, Google Scholar, DOAJ, and the Cochrane Library was conducted through January 2025. Eligible studies reported quantitative pre- and post-operative data on anterior arch morphology. Pooled effect sizes were calculated using a random-effects model with the Knapp-Hartung adjustment. Meta-regression assessed the influence of baseline cleft width and follow-up duration.ResultsTen studies comprising 11 patient cohorts and 265 participants met the inclusion criteria. The pooled mean difference in anterior CW) was -6.217 mm (95% confidence interval (CI): -7.230 to -5.204;  < .001), with substantial heterogeneity (² = 81.8%). Meta-regression identified initial cleft width as a significant predictor ( = -0.842;  = .002), and follow-up duration showed a borderline association ( = -0.387;  = .051). The predictive equation was:    -    -    Lip repair also reduced the anterior curvature angle (MD = -14.66°; 95% CI: -19.62 to -9.7), though heterogeneity was very high (² = 88.1%).ConclusionPrimary lip repair significantly improves anterior arch dimensions in children with UCLP. Initial cleft width predicts postoperative changes, and the proposed model may support early treatment planning. However, due to substantial heterogeneity across studies, small sample sizes in some included cohorts, and very low certainty of evidence for both outcomes (GRADE approach), the findings should be interpreted with caution and considered exploratory.
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