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Frontline workers face 3.4-fold higher risk of COVID-19 infection and significant vaccine hesitancyCOVID-19 risks and vaccine hesitancy among healthcare workers

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Key Takeaway
Recognize that front-line workers face a 3.4-fold higher infection risk and significant vaccine hesitancy.

This narrative review synthesizes the impact of COVID-19 on health workers and rehabilitation professionals, focusing on mortality, vaccine hesitancy, and rehabilitation outcomes. The authors highlight that front-line workers face a 3.4-fold higher risk of testing positive for COVID-19 compared to the general community. Estimates for health worker deaths range from 80,000 to 180,000, with a central estimate of 115,500, while surveillance data reported 6,643 deaths.

Regarding vaccine hesitancy, the review synthesizes various figures: a 37% hesitancy rate in a 91-country survey, a 22.5% rate among 76,471 workers, and a 20.7% refusal rate among nurses. In a French tertiary center, 73.1% were in favor of vaccines, 23.1% were hesitant, and 3.9% were opposed. The review also notes that telerehabilitation yields similar outcomes to center-based pulmonary rehabilitation, though it currently accounts for 6% of outpatient episodes in a large US database.

The authors note that several proposed constructs, including FAS, VRC, TEP, and PCFD, are not validated. These findings suggest a need for improved protection for health workers and better communication regarding vaccination. The review suggests telerehabilitation as a viable component for hybrid care models in pandemic preparedness.

Healthcare workers face unique challenges during a pandemic. Research shows these professionals are at a much higher risk of testing positive for COVID-19, with rates up to 3.4 times higher than the general public. This exposure puts them on the front lines of a crisis that has already resulted in thousands of deaths among their peers.

While many workers are committed to care, the data shows a complex picture regarding vaccine attitudes. Different studies show vaccine hesitancy ranging from about 20% to 37% among various groups of healthcare workers. These numbers highlight the need for better communication and support for those providing essential medical services.

To manage the impact of the virus, some centers are using telerehabilitation, which is remote rehabilitation. This method has shown similar outcomes to traditional in-person pulmonary rehabilitation. These findings help identify where more support is needed for both the workers and the patients they serve.

What this means for you:
Healthcare workers face higher infection risks and varying levels of vaccine hesitancy during the COVID-19 pandemic.

Common questions

Are healthcare workers at higher risk for COVID-19?

Yes, the data shows that front-line workers have a 3.4-fold higher risk of testing positive for COVID-19 compared to the general community. This higher exposure highlights the significant risks these professionals face while providing essential care.

Is remote rehabilitation as effective as in-person care?

Yes, the data shows that telerehabilitation, which is remote rehabilitation, resulted in outcomes similar to center-based pulmonary rehabilitation. This suggests it can be a useful tool for hybrid care models.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedOct 2026
View Original Abstract ↓
COVID-19 placed an unprecedented burden on health workers and disrupted rehabilitation services. Existing reviews have examined health-worker infection and mortality, vaccine hesitancy and telerehabilitation separately; few have considered these dimensions together from the perspective of rehabilitation professionals. Narrative review following SANRA recommendations. PubMed, Scopus and Google Scholar were searched (initial search January 2019–December 2022; updated during revision to December 2025 to capture later publications reporting 2020–2021 data). Sources were selected purposively, prioritising systematic reviews, large multicentre studies and official agency reports. First-person clinical observations from the author's postgraduate training in two French university hospitals are presented separately, in labelled boxes, and are not used as evidence for quantitative claims. WHO estimated 80,000–180,000 health and care worker deaths from COVID-19 between January 2020 and May 2021 (central estimate 115,500), versus 6,643 reported through surveillance. Front-line workers had a 3.4-fold higher adjusted risk of a positive test than the general community. Vaccine hesitancy among health workers was 37% in a 91-country survey and 22.5% in a review of 76,471 workers; a scoping review of nurses reported 20.7% refusal. In a French tertiary centre, 73.1% were in favour, 23.1% hesitant and 3.9% opposed. Physiotherapy guidance addressed acute respiratory care, early mobilisation and post-COVID-19 rehabilitation. Telerehabilitation achieved outcomes similar to centre-based pulmonary rehabilitation, but accounted for only 6% of outpatient episodes in a large US database. Four heuristic constructs are proposed: Frontline Abandonment Syndrome (FAS), Vaccination Refusal Cascade (VRC), Telerehabilitation Emergency Pivot (TEP) and Post-COVID Functional Decoupling (PCFD). Each is positioned against existing terminology and presented as a testable hypothesis rather than a validated construct. COVID-19 exposed gaps in health-worker protection, communication around vaccination and the integration of rehabilitation into pandemic preparedness. Telerehabilitation deserves a defined place in hybrid care models, and the proposed constructs require formal concept analysis and empirical testing.
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