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Systematic review and meta-analysis of laser fluorescence devices for detecting dental caries in childrenLaser fluorescence devices show promise for spotting early tooth decay in children

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Key Takeaway
Consider laser fluorescence devices as adjuncts for monitoring dental caries in children, not replacements for standard exams.

This systematic review and meta-analysis evaluated the diagnostic accuracy of laser fluorescence devices for detecting dental caries in children. The analysis pooled data from twenty-one studies comparing these devices against conventional visual and radiographic methods. Primary outcomes included sensitivity, specificity, and area under the curve (AUC) at different lesion thresholds.

At the D1 threshold, pooled sensitivity was 0.84 (95% CI 0.80–0.87) and specificity was 0.77 (95% CI 0.67–0.84). At the D3 threshold, sensitivity was 0.81 (95% CI 0.77–0.85) and specificity was 0.89 (95% CI 0.84–0.92). The AUC at D1 threshold was 0.86 and at D3 threshold was 0.81.

The authors highlight that heterogeneity was influenced by lesion thresholds, dentition type, reference standards, and diagnostic protocols. Studies with higher risk of bias tended to report greater sensitivity estimates. Safety data, including adverse events, were not reported.

The review concludes that laser fluorescence devices demonstrate good sensitivity for early lesions but show variability in specificity. These devices should complement, rather than replace, conventional visual and radiographic examination due to methodological heterogeneity across studies.

This systematic review and meta-analysis looked at twenty-one studies involving children to see how well laser fluorescence devices detect dental caries. The researchers compared these laser tools against conventional visual and radiographic methods used by dentists today.

The analysis found that the laser devices showed good sensitivity for detecting early lesions. At a specific threshold, the tools correctly identified about 84 percent of early cases. They also showed strong specificity, correctly ruling out healthy teeth about 89 percent of the time at another threshold. The overall diagnostic accuracy was high across the different measurements.

However, the researchers noted important limitations. The results varied based on the settings used for the tests and the type of teeth being examined. Studies with higher risks of bias tended to report better results than more rigorous ones. Safety issues were not reported because none occurred in the reviewed studies.

The main takeaway is that these laser devices may be useful helpers for preventive diagnosis and monitoring. They should complement, rather than replace, standard visual and X-ray exams. Dentists should consider the variability in results when deciding how to use these tools in their practice.

What this means for you:
Laser tools help find early cavities in children but should work alongside standard dental exams.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedMay 2026
View Original Abstract ↓
Early detection of dental caries in children is essential for implementing preventive and minimally invasive treatment strategies. Laser fluorescence–based devices have been proposed as adjunctive diagnostic tools; however, their diagnostic accuracy compared with conventional methods remains uncertain. To evaluate the diagnostic accuracy of laser fluorescence devices compared with conventional visual and radiographic methods for caries detection in pediatric populations. A systematic review was conducted following PRISMA 2020 guidelines and registered in PROSPERO (CRD420251274327). Electronic searches were performed in PubMed/MEDLINE, Scopus, Web of Science, and the Cochrane Library from inception to December 2025. Clinical studies involving children ( Twenty-one studies were included in the qualitative synthesis. Quantitative meta-analysis was conducted for enamel-level (D1) and dentinal-level (D3) diagnostic thresholds. At the D1 threshold (8 studies), pooled sensitivity was 0.84 (95% CI 0.80–0.87) and specificity was 0.77 (95% CI 0.67–0.84), with an area under the curve (AUC) of 0.86. At the D3 threshold (10 studies), pooled sensitivity was 0.81 (95% CI 0.77–0.85) and specificity was 0.89 (95% CI 0.84–0.92), with an AUC of 0.81. Heterogeneity was influenced by lesion thresholds, dentition type, reference standards, and diagnostic protocols. Studies with higher risk of bias tended to report greater sensitivity estimates. Laser fluorescence devices demonstrate good sensitivity for detecting early carious lesions in children and may be useful adjuncts for preventive diagnosis and monitoring. However, variability in specificity and methodological heterogeneity across studies indicate that these devices should complement, rather than replace, conventional visual and radiographic examination. https://www.crd.york.ac.uk/PROSPERO/view/CRD420251274327, identifier CRD420251274327.
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