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Systematic review evaluates SDR, ITB, DBS, and other interventions for functional outcomes in ambulatory children with cerebral palsyNew Surgical Options Are Changing What's Possible for Kids With Cerebral Palsy

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Key Takeaway
Consider multidisciplinary evaluation for treatment selection in ambulatory cerebral palsy patients.

This systematic review assessed multiple interventions for ambulatory children with cerebral palsy, including those with dystonia-predominant phenotypes or mixed presentations. The interventions evaluated included Selective dorsal rhizotomy (SDR), combined dorsal-ventral rhizotomy, peripheral neurectomies, intrathecal baclofen (ITB), deep brain stimulation (DBS) targeting the globus pallidus internus, emerging cerebellar DBS, spinal cord stimulation (SCS), and focused ultrasound. Primary outcomes focused on functional status, motor function, quality of life, muscle tone, walking speed, and spasticity reduction.

Surgical and neuromodulation approaches demonstrated varying degrees of efficacy. SDR was identified as a novel treatment option for spastic diplegia in ambulatory children. Combined dorsal-ventral rhizotomy showed promise for mixed presentations. Peripheral neurectomies provided targeted management with sustained improvements in muscle tone and walking speed for focal spasticity. Intrathecal baclofen (ITB) effectively reduced spasticity and dystonia, although scoliosis progression requires monitoring with this therapy. DBS targeting the globus pallidus internus demonstrated efficacy in dystonia-predominant cerebral palsy, with younger patients showing greater improvement. Emerging cerebellar DBS approaches show early promise for spasticity and mixed presentations.

Spinal cord stimulation (SCS) may benefit select patients with spasticity or painful dystonia, though evidence remains limited. Focused ultrasound represents a novel noninvasive ablative option currently under investigation. Safety data indicated infection rates associated with ITB, while serious adverse events and discontinuations were not reported. The review noted that treatment selection requires multidisciplinary evaluation considering movement disorder phenotype, functional goals, patient age, and family factors.

Key takeaway: Consider multidisciplinary evaluation for treatment selection in ambulatory cerebral palsy patients.

A Condition More Common Than Many Realize

Cerebral palsy (CP) is the most common physical disability in childhood. It affects roughly 1.5 to 2.5 out of every 1,000 babies born. CP is caused by early brain injury or abnormal development, and it shows up differently in every person — some have stiff, tight muscles (spasticity), others have involuntary twisting movements (dystonia), and many have a mix of both.

Medications can help manage symptoms, but they don't always work well enough. When medications fall short, surgery or device-based treatments may offer a path forward.

Why "One Treatment" Was Never the Answer

For a long time, CP management relied heavily on physical therapy, oral medications, and injections to loosen tight muscles. These help many people — but for those with severe, hard-to-control movement disorders, the benefit has limits.

But here's the twist: the emerging picture isn't about one new treatment replacing everything else. It's about a growing menu of targeted options, each matched to a specific type of movement problem and a specific patient profile.

How These Treatments Rewire the Signal

Think of the brain's control over muscles like a volume dial. In CP, that dial is often stuck too loud — sending constant, overwhelming signals that keep muscles tight or trigger uncontrolled movements. Surgical and device-based treatments work by turning the dial down in different ways.

Some procedures cut or modify nerve connections at the spinal level, reducing how much "noise" reaches the muscles. Others implant devices that continuously deliver medication or electrical signals to calm the nervous system. Still others involve placing electrodes deep in the brain to interrupt the faulty signals at their source.

What the Review Covered

This review examined the current evidence on surgical and device-based interventions for CP-related movement disorders in children and adults. Researchers looked at several distinct approaches — from spinal procedures to implanted devices to emerging non-invasive technologies — and evaluated what the evidence shows about who benefits most and when.

What the Evidence Supports

Several treatments showed clear benefit for specific patient groups. Selective dorsal rhizotomy (SDR) — a spinal procedure that cuts overactive nerve fibers — showed strong results for children with spastic diplegia (stiffness mainly in the legs) who can walk. Deep brain stimulation (DBS), which uses implanted electrodes to modulate brain activity, showed meaningful improvements for patients with dystonia-predominant CP, with younger patients tending to benefit more.

A pump-based system that delivers muscle-relaxing medication directly into the spinal fluid reduced both spasticity and dystonia in patients who weren't responding to other treatments. Surgeries targeting specific nerves in the arms or legs provided focused, sustained improvements in muscle tone and walking speed.

Not all of these options are right for every patient — matching the right treatment to the right movement disorder is essential.

Where the Evidence Is Still Building

Some newer approaches — including stimulation of the cerebellum (the brain's movement coordination center) and focused ultrasound (a non-invasive way to target specific brain areas) — are showing early promise but still lack robust clinical trial data. Spinal cord stimulation may help certain patients with painful spasticity, though the evidence base remains limited. These options are being studied, not yet widely adopted.

What This Means for Families

If your child has CP and current treatments aren't providing enough relief, a conversation with a pediatric neurosurgeon or movement disorder specialist may be worth having. These are specialized interventions that require careful evaluation by a multidisciplinary team — including neurologists, surgeons, therapists, and families together. This review reinforces that options exist and are expanding, but they require individualized decision-making. No single treatment fits all patients.

Important Limitations to Keep in Mind

This is a review of existing literature, not a new clinical trial. The quality of evidence varies across different interventions — some are well-established, others rely on small case series. Many studies focused on specific age groups or CP subtypes, so results may not apply broadly. Long-term data on some newer approaches is still being collected.

Researchers are working toward more personalized treatment algorithms — decision frameworks that match each patient's specific movement disorder type, age, and functional goals to the most appropriate intervention. As understanding of CP's underlying brain changes deepens, treatments are expected to become more precisely targeted. Several emerging approaches, including cerebellar DBS and focused ultrasound, are currently under investigation in clinical studies and may expand the options available in the coming years.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedApr 2026
View Original Abstract ↓
Cerebral palsy (CP) affects 1.5–2.5 per 1,000 live births and manifests as diverse movement disorders including spasticity, dystonia, and mixed phenotypes that significantly impact motor function and quality of life. This review examines surgical and neuromodulatory interventions for medically refractory CP-associated movement disorders. Selective dorsal rhizotomy (SDR) offers a novel treatment option for spastic diplegia in ambulatory children (GMFCS II-III), with combined dorsal-ventral rhizotomy showing promise for mixed presentations. Peripheral neurectomies provide targeted focal spasticity management with sustained improvements in muscle tone and walking speed. Intrathecal baclofen (ITB) effectively reduces spasticity and dystonia through programmable drug delivery, though infection rates and potential scoliosis progression require monitoring. Deep brain stimulation (DBS) targeting the globus pallidus internus demonstrates efficacy for dystonia-predominant CP, with younger patients showing greater improvement. Emerging cerebellar DBS approaches show early promise for spasticity and mixed presentations. Spinal cord stimulation (SCS) may benefit select patients with spasticity or painful dystonia, though evidence remains limited. Focused ultrasound represents a novel noninvasive ablative option currently under investigation. Treatment selection requires multidisciplinary evaluation considering movement disorder phenotype, functional goals, patient age, and family factors. As understanding of CP pathophysiology advances, mechanism-based, individualized treatment algorithms will increasingly optimize functional outcomes for this heterogeneous patient population.
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