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Iodine supplementation reduces serum TSH and thyroglobulin levels in iodine-deficient pregnant womenIodine supplements help manage thyroid function in pregnant women

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Key Takeaway
Note that iodine supplementation is associated with reduced serum TSH and thyroglobulin levels in deficient pregnant women.

This meta-analysis evaluates the impact of various iodine supplementation regimens on thyroid function indices among pregnant women with iodine deficiency. The analysis synthesized data across different dosages and trimesters to assess primary outcomes including serum TSH levels, as well as secondary outcomes such as thyroglobulin (Tg) and thyroid volume (TV).

The meta-analysis reported a significant reduction in serum TSH levels (SMD -0.14; 95% CI: -0.23, -0.05; Pz = 0.002). Additionally, thyroglobulin levels were significantly reduced (SMD -0.22; 95% CI: -0.32, -0.13; Pz < 0.001). Regarding thyroid volume, increases were noted in the Europe subgroup and among those receiving supplementation until postpartum (Pz < 0.01).

The authors noted potential publication bias regarding thyroid volume measurements as indicated by Egger's test, though results remained robust after trim-and-fill adjustment. Clinical practice relevance suggests that standardized iodine supplementation reduces serum TSH and Tg in these patients. Greater TSH improvements were specifically observed in Asian populations, during the third trimester, and with daily doses of 200 to 300 mcg potassium iodide.

When a woman is pregnant, her body works overtime to support the growing baby. For those with an iodine deficiency, this extra work can put a strain on the thyroid gland. This study looked at how different amounts of iodine supplements affect thyroid function during pregnancy.

The researchers found that standard iodine supplementation led to lower levels of TSH and thyroglobulin (Tg). These are markers used to measure how well the thyroid is functioning. The results were particularly strong in certain groups, such as women in Asia or those taking specific doses of potassium iodide during their third trimester.

While the findings show a clear link between iodine and improved thyroid indicators, there is some uncertainty regarding thyroid volume measurements due to potential publication bias. However, even with these notes, the data suggests that consistent supplementation helps stabilize key markers for women who lack enough iodine.

What this means for you:
Iodine supplements can lower TSH and thyroglobulin levels in pregnant women with an iodine deficiency.

Common questions

How does iodine help a woman's thyroid during pregnancy?

Iodine is essential for the thyroid gland to function correctly. This study found that taking iodine supplements helped lower serum TSH and thyroglobulin (Tg) levels in pregnant women who were deficient in iodine. These markers help doctors understand how well the thyroid is working while supporting the baby's growth.

Are there specific groups that see better results from iodine?

Yes, some groups showed more significant improvements. Specifically, women in Asian populations, those in their third trimester of pregnancy, and those taking 200 to 300 micrograms of potassium iodide daily saw greater improvements in TSH levels.

What are the limitations of this finding?

The study noted a potential for publication bias regarding thyroid volume (TV) measurements. However, even with these concerns about how data was reported, the results regarding TSH and thyroglobulin levels remained consistent across the different groups studied.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedJun 2026
View Original Abstract ↓
BackgroundThis study aimed to clarify the association between iodine supplementation and thyroid function indices, as well as secondary outcomes including thyroglobulin (Tg) and thyroid volume (TV), in iodine-deficient pregnant women, accounting for different supplementation regimens and trimesters.MethodsChinese and English literature on iodine supplementation in iodine-deficient pregnant women and its associations with thyroid function indices, Tg, and TV was retrieved from PubMed, Medline, Embase, CNKI, WanFang, and WeiPu databases. Effect sizes were estimated using fixed- and random-effects models, reported as standardized mean difference (SMD), odds ratio (OR), and 95% confidence intervals (CIs).ResultsIodine supplementation was associated with reduced serum TSH and Tg levels in iodine-deficient pregnant women (TSH: SMD = −0.14, 95% CI: −0.23, −0.05; Pz = 0.002; Tg: SMD = −0.22, 95% CI: −0.32, −0.13; Pz < 0.001). Subgroup analyses showed significant TSH reductions in Asian populations, third trimester, daily supplementation, 200–300 μg/d doses, and potassium iodide use (Pz < 0.05). Tg was significantly reduced across all regions, iodine supplementation dosages and methods, second/third trimesters, and daily supplementation subgroups (Pz < 0.05). TV was significantly increased in the Europe subgroup and the until postpartum supplementation subgroup (Pz < 0.01). Egger's test suggested publication bias for TV, but results remained robust after trim-and-fill adjustment.ConclusionStandardized iodine supplementation notably reduces serum TSH and Tg in iodine-deficient pregnant women, relieving gestational thyroid dysfunction and optimizing maternal thyroid health. Greater TSH improvements are observed in Asian populations, the third trimester, and those taking 200–300 μg potassium iodide daily.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/view/CRD420261323017, identifier: CRD420261323017.
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