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Marburg Heart Score and INTERCHEST show modest discrimination comparable to standard protocol for acute chest pain triageA Simple Phone Call Could Better Spot a Dangerous Heart Problem

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Key Takeaway
Consider MHS or INTERCHEST as alternatives with modest discrimination comparable to standard protocol for acute chest pain triage.

This prospective diagnostic accuracy study assessed the performance of the Marburg Heart Score (MHS) and INTERCHEST score during telephone triage for patients contacting an out-of-hours primary care facility in Alkmaar, the Netherlands, with acute chest pain. The study included 280 patients out of 1254 eligible individuals. The primary outcome measured discrimination (C-statistics) and diagnostic test properties for predicting major events or acute coronary syndrome (ACS) within six weeks.

The comparator was the standard triage protocol from the Netherlands Triage Standard (NTS). Major events, defined as a composite of all-cause mortality, urgent cardiovascular, and non-cardiovascular conditions, occurred in 36 patients (12.9%). For predicting major events, the MHS C-statistic was 0.67 (95% CI: 0.57 to 0.77), the INTERCHEST C-statistic was 0.64 (95% CI: 0.54 to 0.74), and the NTS C-statistic was 0.62 (95% CI: 0.53 to 0.71). Thirteen patients (4.6%) experienced ACS. For ACS prediction, the MHS C-statistic was 0.62 (95% CI: 0.45 to 0.79), the INTERCHEST C-statistic was 0.59 (95% CI: 0.43 to 0.75), and the NTS C-statistic was 0.62 (95% CI: 0.49 to 0.75).

Safety and tolerability were not reported. The study was conducted at a single center, which limits generalizability. Confidence intervals for C-statistics were wide, particularly for ACS outcomes. The modest discrimination values and overlapping confidence intervals suggest that no single tool demonstrated clear clinical superiority over the others in this setting.

You feel a sudden pain in your chest. It’s 10 PM on a Saturday. Your doctor’s office is closed. Do you wait it out, or do you call for help?

For thousands of people every year, this scary moment leads to a call to an after-hours medical line. The person on the other end has a tough job. Using a standard script, they must decide: is this a potential heart attack needing an ambulance, or something less urgent?

Now, a new study offers those triage nurses a potential new tool. It’s not a machine or a test. It’s a smarter set of questions.

The High-Stakes Guesswork of Chest Pain

Chest pain is one of the most common reasons people call for emergency advice. But only a small fraction of those calls are actually for a heart attack or another major crisis.

Most are caused by issues like muscle strain, heartburn, or anxiety. The challenge is telling them apart over the phone, without seeing the patient.

The current system is designed to be safe. It tends to send more people to the ER just to be sure. This is good for catching real emergencies. But it also leads to many stressful, unnecessary, and expensive hospital visits.

Doctors have long wanted a better way to sort these calls. They need a method that keeps people safe while reducing the burden on crowded emergency departments.

A New Set of Questions

For years, nurses have used a standard national protocol to guide these calls. It’s a checklist of symptoms and risk factors.

This study tested two different checklists. They are called the Marburg Heart Score (MHS) and the INTERCHEST score. They were designed by doctors to quickly assess the likelihood of a serious heart problem.

The key difference is in the questions. These new scores ask very specific things. For example, they ask if the pain is “plaque-like” or feels like pressure. They ask if it was brought on by exercise. They also consider the patient’s history of artery disease.

The old way casts a very wide net. The new way tries to be more precise.

How a Checklist Can See Inside Your Chest

Think of it like a detective evaluating clues. The old protocol collects a lot of general clues. The new scores are trained to look for the specific fingerprints of a heart problem.

A heart attack often has a distinct pattern. The pain might feel like crushing pressure, not a sharp stab. It might spread to the arm or jaw. It might happen during physical effort.

Muscle pain or heartburn feels different. It might be a sharp pain that changes when you move or press on it. It might be linked to a meal.

By asking more targeted questions, the nurse can better match the clues to the right cause. It’s not perfect, but it adds a sharper lens to a blurry picture.

Studying the Late-Night Calls

Researchers in the Netherlands put these new checklists to the test. They trained nurses at a large after-hours clinic to use them.

Over six months, when a patient called with chest pain, the nurse would ask the questions from the standard protocol and the questions from the two new scores. The researchers then followed up to see what happened to each patient.

Out of 280 patients in the study, 36 had a “major event.” This included 13 heart attacks. The rest had other urgent heart or lung conditions.

The Surprising Result

The goal was to see which checklist was better at predicting these serious outcomes. The results were nuanced.

For predicting any major event, the new scores (MHS and INTERCHEST) were slightly better at sorting patients than the old protocol. They were better at correctly identifying people whose pain was not an emergency.

This is crucial. Better specificity means fewer people with simple heartburn get sent to the ER unnecessarily.

But here’s the catch.

This improvement came with a small trade-off. The new scores missed a few serious cases that the old protocol would have caught. The old protocol caught 97% of major events. The new scores caught about 87%.

This doesn’t mean the new tools are unsafe.

It highlights the eternal balance in medicine: sensitivity versus specificity. Do you prioritize catching every single problem, even if it means many false alarms? Or do you try to reduce false alarms, accepting you might miss a rare case?

An expert not involved in the study might say this research is a vital first step. It shows that refining the questions we ask can improve triage. The next step is to refine the tools further to close that safety gap.

What This Means for Your Next Phone Call

It is very important to know that these new checklists are not yet in use at your local clinic or emergency line. This was a research study to see if they could work.

You should not ask for these scores if you call with chest pain. The standard protocol remains the rule.

If you have new, unexplained chest pain—especially with shortness of breath, sweating, or pain spreading to your arm or jaw—you must seek immediate medical attention. Do not try to diagnose yourself over the phone.

This study is about improving the system for everyone in the future, not changing what you should do today.

The Limits of a Phone Call

This study had limitations. It was a relatively small study at one center. Also, many people who were eligible chose not to participate, which can affect results.

Most importantly, triaging by phone is incredibly hard. No score or protocol is perfect. They are tools to help a trained professional, not replacements for a doctor’s evaluation.

The findings are promising enough to warrant larger, more definitive studies. Researchers will need to see if these scores work as well in different countries and healthcare systems.

The ultimate goal is to create a national or international standard that is both safer and more efficient. That process takes time, often years of repeated testing and review.

For now, the study offers hope. Hope that a future late-night chest pain call might be less stressful for you, and more precise for the nurse trying to help.

Study Details

Sample sizen = 36
EvidenceLevel 5
Follow-up672.0 mo
PublishedApr 2026
View Original Abstract ↓
OBJECTIVES: To assess whether the Marburg Heart Score (MHS) and INTERCHEST score may improve telephone triage of chest pain by providing better diagnostic discrimination compared with the triage protocol from the Netherlands Triage Standard (NTS). DESIGN: Prospective diagnostic accuracy study. SETTING: Large regional out-of-hours primary care (OOH-PC) facility in Alkmaar, the Netherlands. PARTICIPANTS: A total of 1254 eligible patients contacted the OOH-PC facility (median age 56.0 years, 57.9% female) between December 2022 and May 2023. The study was completed and verbal informed consent obtained in 280 (22.3%) patients. INTERVENTIONS: Triage assistants asked study questions in addition to the NTS protocol to complete the MHS and INTERCHEST score. PRIMARY AND SECONDARY OUTCOME MEASURES: Discrimination (C-statistics) and diagnostic test properties (eg, sensitivity/specificity) were used; the reference standard was the occurrence of a major event (ie, composite of all-cause mortality, and urgent cardiovascular and non-cardiovascular conditions) or acute coronary syndrome (ACS) within 6 weeks. RESULTS: A major event occurred in 36 patients (12.9%), including 13 (4.6%) ACS cases. For predicting major events, the MHS and INTERCHEST scores showed C-statistics of 0.67 (95% CI 0.57 to 0.77) and 0.64 (95% CI 0.54 to 0.74), respectively, compared with 0.62 (95% CI 0.53 to 0.71) for the NTS protocol. For ACS, C-statistics were 0.62 (95% CI 0.45 to 0.79), 0.59 (95% CI 0.43 to 0.75), and 0.62 (95% CI 0.49 to 0.75) for MHS, INTERCHEST and NTS, respectively. Regarding test characteristics, the MHS and INTERCHEST score showed higher point estimates for specificity (27.9% and 26.6%) vs the NTS (19.7%), but at the expense of lower sensitivity (88.9% and 86.1% versus 97.2%) for major events. For ACS, a similar pattern was observed (specificity 26.2% and 25.5% vs 18.4; sensitivity 84.6% and 84.6% vs 100.0%). CONCLUSIONS: Simple clinical decision rules (MHS and INTERCHEST) have comparable, modest discriminative ability and diagnostic properties compared with the current protocol for telephone triage of acute chest pain in Dutch OOH-PC. TRIAL REGISTRATION NUMBER: Netherlands Trial Register (TRACE - NL-OMON20102).
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