Mode
Text Size
Log in / Sign up

Permanent night shift work associated with increased chronic kidney disease risk in UK Biobank participantsPermanent night shift work linked to kidney disease risk

AI-generated summary of the cited source, checked by automated accuracy review. How we work

Key Takeaway
Note the observed association between permanent night shift work and increased chronic kidney disease risk.

This prospective cohort study analyzed data from the UK Biobank, including 252,425 participants for current night shift analysis and 67,097 for lifetime exposure. The researchers investigated the association between night shift work patterns, including permanent night shifts, duration, frequency, and shift length, and the incidence of chronic kidney disease (CKD).

Compared to individuals who never or rarely worked night shifts, permanent night shift workers demonstrated a significantly higher risk of CKD with a hazard ratio of 1.19 (95% CI 1.06 to 1.34). Additionally, the study suggested that participants with high genetic risk and permanent night shift exposure had the highest CKD risk, with a hazard ratio of 2.49 (95% CI 2.07 to 2.99).

Safety and tolerability data regarding adverse events or discontinuations were not reported. Because this was an observational study, the results show an association rather than a causal relationship. The interaction between genetic risk and shift exposure was suggested (P < 0.05) but not confirmed.

While these findings suggest that optimizing shift schedules may help reduce CKD incidence, the study is limited by its observational design. Clinicians should interpret these results as an association between specific work patterns and kidney disease risk.

If your job requires you to work through the night, your long-term kidney health might be at stake. A large study looking at over 250,000 people found that those working permanent night shifts faced a higher risk of developing chronic kidney disease (CKD).

Researchers analyzed data from the UK Biobank to see how shift patterns affect kidney health. They found that permanent night shift workers had a 19 percent higher risk of developing the condition compared to people who rarely or never worked nights. The study also suggested that the risk might be even higher for people who already have a high genetic risk for kidney disease and work permanent night shifts.

It is important to remember that this was an observational study. This means the researchers found an association between night shifts and kidney disease, but they did not prove that the shifts actually cause the damage. There could be other factors involved. However, these findings suggest that changing how we schedule shifts might help protect kidney health in the future.

What this means for you:
Permanent night shifts are linked to a higher risk of chronic kidney disease.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
ObjectiveTo investigate the association between night shift work and chronic kidney disease (CKD) risk and evaluate the interacting role of genetic susceptibility.MethodsThis prospective cohort study included 252,425 participants from the UK Biobank for current night shift analysis and 67,097 for lifetime exposure. Cox proportional hazards models assessed the relationship between various shift patterns and CKD incidence. Formal interaction analyses (additive and multiplicative scales) and sensitivity analyses were conducted. Reporting followed STROBE guidelines.ResultsCompared to those who never or rarely worked night shifts, permanent night shift workers had a significantly higher CKD risk (HR 1.19, 95% CI 1.06–1.34). Lifetime analyses revealed significant associations between incident CKD risk and duration, frequency, shift length, and consecutive shifts. Participants with high genetic risk and permanent night shift exposure had the highest CKD risk (HR 2.49, 95% CI 2.07–2.99). Potential interactions between genetic susceptibility and specific night shift patterns were suggested (P < 0.05). Sensitivity analyses further confirmed the robustness of these associations.ConclusionsNight shift work—particularly permanent schedules and adverse shift patterns—increases the risk of CKD, especially among individuals with high genetic predisposition. Optimizing shift schedules may help reduce CKD incidence.
Free Newsletter

Clinical research that matters. Delivered to your inbox.

Join thousands of clinicians and researchers. No spam, unsubscribe anytime.