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Cohort study of 910 Chinese nurses links mental health, night shifts to metabolic disease trajectoriesFor nurses, what matters more for metabolic health: diet or mental strain?

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Key Takeaway
Note: Observational links between mental health, night shifts, and metabolic disease in nurses; causation not established.

This cohort study followed 910 nurses in China from 2018 to 2022 to examine the relationship between lifestyle, night shift patterns, mental health, and trajectories of metabolic diseases. The study identified three distinct metabolic disease trajectories: Maintaining-Low, Chronically-High, and a Maintaining-Low group. The analysis compared these groups to the Maintaining-Low reference group.

The main findings show that, compared to the Maintaining-Low group, correlates of the Chronically-High trajectory included a lack of dietary preference for vegetables and lack of exercise. Among nurses who started with a high initial health level, the increase in the number of metabolic diseases was correlated with mental health factors and night shift patterns, rather than unhealthy lifestyles. Specific mental health correlates included low depression scores and high anxiety scores, alongside a night shift pattern associated with a slow increase in metabolic diseases. Exact numbers, effect sizes, and statistical significance for these associations were not reported.

This is an observational cohort study, meaning it can only show associations, not causation. Key limitations include the lack of reported effect sizes and statistical measures, and the findings may not be generalizable beyond the specific population of Chinese nurses. Safety and tolerability data were not reported. For practice, these findings highlight potential modifiable risk factors in a high-stress profession but require confirmation with more rigorous study designs.

Imagine you're a nurse trying to stay healthy. You know diet and exercise matter, but what about the stress of the job itself? A study tracking 910 nurses in China from 2018 to 2022 tried to map out how their metabolic health—conditions like high blood pressure or diabetes—changed over time. They found three main paths: some stayed consistently healthy, some were chronically unhealthy, and some saw their health decline.

For the nurses who were chronically unhealthy, the study linked their path to a lack of preference for vegetables and a lack of exercise. This fits with what we might expect. But the more surprising finding was for nurses who started out in good health. For them, an increase in metabolic diseases wasn't tied to unhealthy lifestyle habits. Instead, it was correlated with their mental health and their night shift patterns.

Specifically, lower depression scores and higher anxiety scores, along with certain night shift schedules, were associated with a slow increase in metabolic problems. It's important to remember this was an observational study. It shows these factors are connected, but it can't prove that night shifts or anxiety directly cause the diseases. The study also didn't report specific numbers on how strong these links were, and the findings are specific to this group of nurses in China. Still, it paints a picture where the mental toll and irregular hours of nursing might weigh as heavily on the body as traditional lifestyle factors, at least for some.

What this means for you:
For nurses, mental health and shift work may be as linked to metabolic disease as diet and exercise.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
The study aimed to examine the relationship between lifestyle, night shift pattern, mental health and nurses’ metabolic diseases. We included 910 nurses from 2018 to 2022. The Growth mixture model was used to identify the trajectories of metabolic diseases among nurses. And multinomial logistic regression was used to examine the relationship between lifestyle, night shift pattern, mental health and the trajectories of metabolic diseases. Three distinct trajectories were identified: Maintaining-Low, Chronically-High group, Maintaining-Low group. Compared to the Maintaining-low group, the correlates of Chronically-high group were lack of dietary preference for vegetables and exercise. Low depression scores, high anxiety scores, night shift pattern with a slow increase in metabolic diseases. The changes of the number of metabolic diseases among nurses in China are heterogeneous. Lack of dietary preference for vegetables and exercise are significantly related to nurses’ metabolic disorders. Among nurses with high initial health level, the correlates of the increase in the number of metabolic diseases are not unhealthy lifestyles, but mental health and night shift pattern.
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