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Avascular osteonecrosis of the jaw is a rare but severe complication following orthognathic surgeryManaging jaw bone death after corrective jaw surgery

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Key Takeaway
Recognize avascular osteonecrosis as a rare, severe complication of orthognathic surgery often involving the maxilla.

This systematic review synthesizes data from 17 studies involving 33 cases to evaluate the clinical characteristics and management of avascular osteonecrosis of the jaw in patients undergoing orthognathic surgery. The authors identify this condition as a rare but severe postoperative complication.

Key findings indicate that necrosis is predominantly located in the maxilla, with 28/33 cases occurring in the maxilla and 18/33 specifically in the alveolar bone of the maxilla. Early symptoms were reported in 14/33 cases as gingival or soft tissue discoloration. Progressive symptoms included tooth loss, alveolar bone loss, and oronasal fistulas. Surgical management strategies for these cases included bone grafting and flap reconstruction in 13/33 instances.

The authors note significant limitations, specifically the small sample size of 33 cases and the overall need for higher-quality studies to better understand the condition. Clinical evidence is currently limited by these factors. The review provides preliminary information on clinical characteristics and management strategies but requires more robust data to establish definitive protocols.

When patients undergo orthognathic surgery to correct jaw alignment, they can occasionally face a serious complication called avascular osteonecrosis. This condition involves the death of bone tissue due to a lack of blood supply. While it is considered rare, it can lead to significant issues like tooth loss or the formation of openings between the mouth and nose.

A review of 33 cases across 17 studies shows that this condition most often appears in the upper jaw (maxilla). Early warning signs typically include discoloration of the gums or surrounding soft tissues. If left unmanaged, it can progress to more severe symptoms like bone loss or fistulas.

Treatment for those affected often involves surgical interventions such as bone grafting and flap reconstruction. Because the current data comes from a small number of cases, doctors still need more high-quality research to fully understand how to manage this complication effectively.

What this means for you:
Avascular osteonecrosis is a rare but serious jaw complication that usually appears in the upper jaw after surgery.

Common questions

What are the early signs of bone issues after jaw surgery?

Early symptoms of avascular osteonecrosis often include discoloration of the gums or other soft tissues. In about 14 out of 33 cases reviewed, this discoloration was noted. Identifying these changes early is important for determining if surgical intervention like bone grafting is needed.

Where does this condition usually occur in the jaw?

The condition is predominantly located in the maxilla (the upper jaw). Specifically, 28 out of 33 cases were found in the maxilla, with 18 of those cases occurring specifically in the alveolar bone of the maxilla.

How is avascular osteonecrosis treated after surgery?

Management often involves surgical techniques such as bone grafting and flap reconstruction. These procedures are used to address the damaged tissue. However, because the current evidence comes from a small sample of 33 cases, more research is needed to establish standard protocols.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedJun 2026
View Original Abstract ↓
Orthognathic surgery plays a crucial role in restoring occlusal function and improving facial aesthetics. Avascular osteonecrosis of the jaw is a rare but severe postoperative complication. Here, we reviewed the clinical characteristics and management of avascular osteonecrosis of the jaw following orthognathic surgery. A systematic review of published studies up to April 2026 was conducted. Data on clinical features, potential contributing factors, and management strategies were collected. This review included 17 studies encompassing 33 cases. Avascular osteonecrosis of the jaw was predominantly located in the maxilla (28/33), with the majority of cases (18/33) affecting the alveolar bone of the maxilla. Early symptoms primarily included gingival or soft tissue discoloration (14/33). As necrosis progressed, symptoms such as tooth loss, alveolar bone loss, oronasal fistulas, and others were observed. Management followed a staged approach: non-surgical interventions for initial control and surgical interventions for progressive cases. Thirteen cases ultimately underwent bone grafting and flap reconstruction. Larger sample sizes and higher-quality studies are needed to further understand this rare but serious complication.
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