Mode
Text Size
Log in / Sign up

Extended early intervention service improves functioning in first-episode psychosis versus standard careExtending early intervention services may improve functioning for some young people with first-episode psychosis

AI-generated summary of the cited source, checked by automated accuracy review. How we work

Key Takeaway
Consider extended EIS for FEP patients with ongoing difficulties, but note limited outcome reporting.

This randomized controlled trial evaluated whether extending Early Intervention Service (EIS) for one additional year improved outcomes for individuals with first-episode psychosis (FEP) compared to transitioning to standard care (SC) after completing the standard two-year EIS program. The study enrolled 400 individuals aged 15-55 years with FEP who had completed two years of EIS. The primary outcome was not reported.

Secondary analyses showed that extended EIS improved functioning relative to SC across several measures. Employment rates were higher with extended EIS (p = 0.024). Role Functioning Scale (RFS) total and subdomain scores increased with extended EIS (p < 0.001 to 0.015). Social and Occupational Functioning Assessment Scale (SOFAS) scores were better with extended EIS (p < 0.001). For symptom measures, younger patients showed greater reductions in overall symptom severity (p = 0.014) and general psychopathology (p = 0.020) with extended EIS. The study did not report absolute numbers, effect sizes, or safety and tolerability data.

Key limitations include the lack of a reported primary outcome, which makes it difficult to assess the study's main objective. The absence of absolute numbers and effect sizes limits clinical interpretation of the magnitude of benefit. No safety or adverse event data were reported. The practice relevance is that extending EIS for individuals who continue to demonstrate functional or clinical difficulties after the initial two-year program may help optimize long-term recovery, but these findings are from secondary analyses and require confirmation.

Researchers analyzed data from two randomized controlled trials involving 400 people aged 15 to 55 years with first-episode psychosis. These participants had finished a two-year Early Intervention Service program and were then split into two groups: one continued with an additional year of EIS, while the other transitioned to standard care. The team assessed outcomes like employment, social functioning, and symptom severity over the next two years, with follow-up at three years.

The analysis found that those who received the extended year of EIS generally showed better results. Specifically, employment rates were higher, and scores measuring role functioning and social adjustment were improved compared to the group that moved to standard care. Younger patients also experienced greater reductions in overall symptom severity and general psychopathology during this period.

No safety concerns, adverse events, or discontinuations were reported in the available data. However, because the study did not report primary outcomes or absolute numbers, the practical impact on individual patients remains uncertain. Readers should understand that while extending care may help those with ongoing difficulties, this evidence comes from secondary analyses and should not be taken as a definitive rule for all treatment plans.

What this means for you:
Extended early intervention services showed better functioning outcomes than standard care in this study, though safety data were not reported.

Study Details

Study typeRct
EvidenceLevel 2
PublishedApr 2026
View Original Abstract ↓
BACKGROUND: This study examined the functional and clinical effects of extending Early Intervention Service (EIS) for individuals with first-episode psychosis (FEP) by one additional year, compared with transitioning to standard care (SC) after completing two years of EIS. Age and duration of untreated psychosis (DUP) were explored as potential moderators across a broad age range (15-55 years). METHODS: Secondary analyses were conducted on two randomised controlled trials involving 400 FEP patients who had completed two years of EIS (extended EIS: n = 202; SC: n = 198). Participants were assessed at two years and again at three years. Multiple linear regression and mixed-effects models were used to evaluate treatment effects and the moderating roles of age (<25 vs ≥25 years) and DUP (<92 vs. ≥92 days). RESULTS: Extended EIS improved functioning relative to SC, including higher employment rates (p = 0.024), increased Role Functioning Scale (RFS) total and subdomain scores (p < 0.001 to 0.015), and better Social and Occupational Functioning Assessment Scale (SOFAS) scores (p < 0.001). Short DUP was associated with greater gains in certain RFS subdomains (p = 0.003 to 0.008) and SOFAS (p < 0.001). Younger patients showed greater improvements in RFS independent living and self-care (p = 0.019), and reductions in overall symptom severity (p = 0.014) and general psychopathology (p = 0.020). CONCLUSIONS: A one-year extension of EIS produced additional functional benefits, with stronger effects observed among younger patients and those with shorter DUP. Extending EIS for individuals who continue to demonstrate functional or clinical difficulties after the initial two-year programme may help optimise long-term recovery and guide efficient service planning.
Free Newsletter

Clinical research that matters. Delivered to your inbox.

Join thousands of clinicians and researchers. No spam, unsubscribe anytime.