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Systematic review and meta-analysis of insomnia prevalence and risk factors in patients with coronary heart diseaseHalf of All Heart Disease Patients Can't Sleep — Here's Why That's Dangerous

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Key Takeaway
Note high insomnia prevalence in CHD patients, especially females and those with depression, diabetes, or gastritis.

A systematic review and meta-analysis examined the prevalence of insomnia and its influencing factors among 5,928 patients diagnosed with coronary heart disease. The study pooled data to determine the overall frequency of insomnia and analyzed specific demographic and clinical variables associated with higher risk.

The overall pooled prevalence of insomnia was 51.8% (95% CI: 0.446–0.590, P < 0.001). Significant risk factors included female sex (OR = 2.00; 95% CI: 1.58–2.52), anxiety (OR = 1.61; 95% CI: 1.36–1.91), depression (OR = 2.15; 95% CI: 1.48–3.13), coronary heart disease duration of 3 years or more (OR = 1.73; 95% CI: 1.25–2.40), diabetes (OR = 1.50; 95% CI: 1.45–1.56), and gastritis (OR = 2.24; 95% CI: 1.62–3.11). All associations demonstrated statistical significance (P < 0.001 or P = 0.001).

Safety and tolerability data, including adverse events and discontinuations, were not reported in the included studies. No specific limitations were detailed in the provided evidence, and funding or conflict of interest information was not reported. The findings reflect observational associations rather than causal relationships.

These results suggest that insomnia is highly prevalent in patients with coronary heart disease and is linked to several modifiable and non-modifiable factors. Clinicians should prioritize early identification and intervention targeting modifiable risk factors, particularly in female patients and those with a CHD duration of 3 years or more.

The sleep problem hiding in plain sight

Coronary heart disease (CHD) is the leading cause of death worldwide. It happens when the arteries that supply blood to the heart get narrowed or blocked — usually by a buildup of fatty deposits. Heart attacks, chest pain, and reduced stamina are common results.

Most cardiac care focuses on blood pressure, cholesterol, and medications. Sleep often gets left out of the conversation. But sleep is when the heart recovers. Poor sleep raises blood pressure, increases inflammation, and makes the heart work harder than it should.

What we used to miss

Doctors have long known that sleep apnea — where breathing stops during sleep — is dangerous for the heart. A lot of attention goes there.

But here's the twist: insomnia, which is simply the inability to fall asleep or stay asleep even when you have the chance, is actually more common than sleep apnea in adults. And until recently, very little was known about just how prevalent it is among people with heart disease.

Why the heart-sleep connection is so strong

Think of sleep as a nightly maintenance window for your cardiovascular system. During deep sleep, blood pressure drops, heart rate slows, and the body repairs inflammation. When that window gets disrupted night after night, the damage accumulates — like a machine that never gets switched off for servicing.

Insomnia disrupts this process constantly. And the conditions that often accompany heart disease — anxiety, depression, chronic pain, diabetes — all make insomnia worse. It becomes a self-reinforcing cycle that's hard to break.

What this study looked at

Researchers conducted a systematic review and meta-analysis — pulling together 19 studies involving 5,928 patients with confirmed coronary heart disease. They looked at how common insomnia was across these patients and what factors made it more likely. The work was published in Frontiers in Medicine in April 2026.

The pooled prevalence of insomnia was 51.8%. In plain terms: about one in two CHD patients meets the criteria for clinically significant insomnia. That's a striking number.

The analysis also identified the factors most strongly associated with insomnia in this group. Women were twice as likely as men to have insomnia. Depression raised the odds by more than two times, and gastritis (stomach inflammation) raised them even higher. Anxiety, diabetes, and having had heart disease for three or more years all significantly increased risk as well.

This means insomnia in heart disease patients isn't random — it follows patterns that doctors can identify and act on.

A condition that flies under the radar

Despite these numbers, insomnia is consistently underdiagnosed in cardiology settings. Patients rarely bring it up, and cardiologists rarely ask. Sleep is seen as a "soft" complaint compared to chest pain or shortness of breath.

But failing to treat insomnia in someone with heart disease may be letting a modifiable risk factor go unchecked. Treating depression, anxiety, and diabetes — all of which worsen insomnia — could have a compounding benefit for heart health too.

If you have coronary heart disease and you're struggling to sleep, bring it up with your doctor. Don't wait to be asked. Mention how long you've been having trouble, whether anxiety or low mood plays a role, and whether conditions like diabetes or stomach problems are part of your picture.

Cognitive behavioral therapy for insomnia (CBT-I) is a proven, medication-free treatment that works well even in people with other health conditions. Some sleep medications are also appropriate for cardiac patients. The key is getting the conversation started.

Limitations to keep in mind

The 19 studies in this review came from different countries and used different ways to measure insomnia — some relied on questionnaires, others on clinical interviews. This variation can affect how comparable the results are. The majority of participants were from China, which may limit how well the findings apply to other populations.

Researchers are calling for insomnia to be formally included in cardiac rehabilitation programs and post-heart-attack care protocols. Future clinical trials need to test whether actively treating insomnia in CHD patients can improve heart outcomes — not just sleep. That research is only beginning, but the case for taking sleep seriously in cardiac care has never been stronger.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedApr 2026
View Original Abstract ↓
BackgroundSleep is a pivotal component of cardiovascular health. However, clinical efforts in coronary heart disease (CHD) disproportionately focus on sleep-disordered breathing, while insomnia, the most prevalent sleep disorder among adults, remains underdiagnosed and undertreated.AimsThis meta-analysis systematically evaluates the prevalence of insomnia and its influencing factors in patients with CHD to inform clinical prevention and management strategies.MethodsTen databases were searched from inception to 7 September 2025. The prevalence rates, odds ratios (ORs), and 95% confidence intervals (CIs) were extracted to evaluate the prevalence of insomnia and its influencing factors in patients with CHD. RevMan 5.4 and Stata 15.0 software was used for data processing. Subgroup analyses, meta-regression, and sensitivity analyses were performed.ResultsNineteen studies involving 5928 patients with CHD were included. The overall pooled prevalence of insomnia was 51.8% (95% CI: 0.446–0.590, P < 0.001). Significant risk factors identified were female sex(OR = 2.00, 95% CI: 1.58–2.52, P < 0.001), anxiety (OR = 1.61, 95% CI: 1.36–1.91, P < 0.001), depression (OR = 2.15, 95% CI: 1.48–3.13, P < 0.001), CHD duration ≥3 years (OR = 1.73, 95% CI: 1.25–2.40, P = 0.001), diabetes (OR = 1.50, 95% CI: 1.45–1.56, P < 0.001), and gastritis (OR = 2.24, 95% CI: 1.62–3.11, P < 0.001).Conclusioninsomnia has a substantial prevalence in patients with CHD. Clinicians should prioritize early identification and intervention targeting modifiable risk factors (anxiety, depression, diabetes, and gastritis), particularly in female patients and those with a CHD duration ≥3 years.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024617785.
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