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Criminal legal involvement correlates with baseline symptoms and substance use in US first-episode psychosis patients.

Criminal legal involvement correlates with baseline symptoms and substance use in US first-episode p…
Photo by micheile henderson / Unsplash
Key Takeaway
Note that baseline criminal legal involvement correlates with specific risk factors in first-episode psychosis patients.

This study was a secondary analysis of a cluster randomized controlled trial involving 381 individuals with first-episode psychosis in the US. The primary outcome assessed was criminal legal involvement (CLI), measured at baseline and over a 24-month follow-up period. Secondary outcomes included dropping out of treatment due to incarceration.

At baseline, 11% of the sample reported CLI within the past month. Over the 2-year follow-up, 13.6% of the sample reported CLI. Baseline CLI was significantly associated with lower education, longer duration of untreated psychosis, lifetime alcohol or any drug use disorder (other than cannabis), and more severe excitement factor symptoms on the PANSS. Over the follow-up, CLI was predicted by longer duration of untreated psychosis, schizophrenia diagnosis, lifetime alcohol or any other drug use disorder, recent alcohol or cannabis use, and more severe positive and excitement symptoms at baseline. Those with CLI at baseline were nearly 3 times more likely to have subsequent CLI. Baseline CLI was also associated with dropping out of treatment due to incarceration.

Safety and tolerability data regarding adverse events were not reported. The study notes that limited research has evaluated CLI during a first episode of psychosis. Causality of the reported associations was not explicitly stated, and generalizability beyond the US is uncertain. The practice relevance suggests that CLI in people with first-episode psychosis could be reduced by earlier detection and more effective treatment of psychotic symptoms, substance use, and criminogenic risk factors.

Study Details

Study typeRct
Sample sizen = 381
EvidenceLevel 2
Follow-up24.0 mo
PublishedMar 2026
View Original Abstract ↓
Because limited research has evaluated criminal legal involvement (CLI) during a first episode of psychosis (FEP), we explored rates, correlates, and predictors of CLI among people with FEP. We conducted a secondary analysis on the Recovery After an Initial Schizophrenia Episode-Early Treatment Program (RAISE-ETP) study, a cluster randomized controlled trial conducted from 2010 to 2012 with people experiencing FEP in the US. We explored rates of recent CLI prior to baseline and over the 2-year follow-up and evaluated predictors of CLI at baseline and over the follow-up period (N = 381). At baseline, 11% of the sample reported CLI within the past month, which was significantly associated with lower education, longer duration of untreated psychosis, lifetime alcohol or any drug use disorder (other than cannabis), and more severe excitement factor symptoms on the Positive and Negative Syndrome Scale (PANSS). Over the 2-year follow-up, 13.6% of the sample reported CLI which, controlling for baseline CLI, was predicted by longer duration of untreated psychosis, schizophrenia diagnosis, lifetime alcohol or any other drug use disorder, alcohol or cannabis use in the 30 days prior to baseline, and more severe positive and excitement symptoms on the PANSS at baseline. Those with CLI at baseline were nearly 3 times more likely to have subsequent CLI over the follow-up. Baseline CLI was associated with dropping out of treatment due to incarceration. The findings suggest that CLI in people with FEP could be reduced by earlier detection and more effective treatment of psychotic symptoms, substance use, and criminogenic risk factors. Data used in this secondary analysis are from ClinicalTrials.gov identifier: NCT01321177.
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