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Meta-analysis finds 58% prevalence of dementia-relevant MRI abnormalities in LMIC patientsWhat does a brain scan show when dementia is suspected in poorer countries?

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Key Takeaway
Interpret the 58% MRI abnormality prevalence in LMIC dementia patients with caution due to high heterogeneity.

This systematic review and meta-analysis examined the prevalence and patterns of dementia-relevant structural brain MRI abnormalities in adults aged 50 years or older with suspected or confirmed dementia in low- and middle-income countries (LMICs). The analysis included 23 studies contributing data from 2,513 participants. The comparator was not explicitly reported, and the review focused on brain MRI as part of the diagnostic evaluation.

The primary finding was that dementia-relevant structural MRI abnormalities were present in 1,248 of 2,513 participants, yielding a pooled prevalence estimate of 58% (95% CI 43% to 72%). Secondary outcomes, including MRI protocols and the incremental diagnostic contribution of MRI beyond cognitive screening, were synthesized narratively due to heterogeneous reference standards and incomplete reporting. Safety and tolerability data were not reported.

Key limitations include substantial statistical heterogeneity (I²=95%), a wide prediction interval (8% to 96%), marked between-study variability, and a high risk of bias in the included studies. The authors note that diagnostic-accuracy outcomes could not be meta-analyzed quantitatively. The pooled estimate should be interpreted as a descriptive summary of heterogeneous study-level findings rather than a precise population parameter.

For practice, the review suggests structured visual ratings of MRI may add aetiologic specificity beyond cognitive screening in LMIC settings. However, clinicians should recognize the high uncertainty in the prevalence estimate due to the heterogeneity of the underlying evidence. The findings highlight a need for more standardized diagnostic studies in these populations.

Getting a clear diagnosis of dementia is hard everywhere, but it can be especially challenging in countries with fewer medical resources. A new review of existing research looked at what happens when doctors in these settings use brain MRI scans to help figure things out. The analysis pooled data from over 2,500 people and found that, on average, about 58% of scans showed physical brain changes that could be relevant to dementia. That means for many people, the scan provided a visual clue that went beyond just memory tests.

It's important to understand what this number does and doesn't tell us. The review combined 23 different studies, and their results varied wildly—from finding these brain changes in as few as 8% of people to as many as 96%. This huge variation means the overall 58% figure is more of a rough summary than a precise prediction for any single clinic or country. The quality and methods of the original studies also differed a lot.

The takeaway is that an MRI scan can often show something tangible when dementia is suspected, which may help doctors understand the possible cause. However, because the evidence is so mixed and inconsistent, we can't yet say how definitively a scan changes a diagnosis or improves care in these specific settings. More standardized research is needed to know how best to use this tool.

What this means for you:
Brain scans often show changes in suspected dementia, but results vary too much to be a sure thing.

Study Details

Study typeMeta analysis
Sample sizen = 2,513
EvidenceLevel 1
Follow-up600.0 mo
PublishedApr 2026
View Original Abstract ↓
OBJECTIVES: To synthesise the prevalence and patterns of dementia-relevant structural brain MRI abnormalities in adults with suspected or confirmed dementia in low- and middle-income countries (LMICs), and to summarise MRI protocols and the incremental diagnostic contribution of MRI beyond cognitive screening. DESIGN: Systematic review and meta-analysis. DATA SOURCES: PubMed, EMBASE, Web of Science and PsycINFO (January 1990-27 January 2025), plus reference list screening and targeted manual searches. ELIGIBILITY CRITERIA: Observational or diagnostic-accuracy studies from World Bank-defined LMICs including adults (≥50 years) with suspected or confirmed dementia who underwent brain MRI as part of diagnostic evaluation. DATA EXTRACTION AND SYNTHESIS: Two reviewers independently screened, extracted data and assessed risk of bias using ROBINS-I. Random-effects models pooled prevalence of dementia-relevant MRI abnormalities; diagnostic-accuracy outcomes were synthesised narratively due to heterogeneous reference standards and incomplete reporting. RESULTS: 39 LMIC studies were included; 23 studies (2513 participants) contributed to the meta-analysis. Dementia-relevant MRI abnormalities (defined as ≥1 clinically relevant structural abnormality per study definition) were present in 1248/2513 participants. The pooled prevalence of dementia-relevant MRI abnormalities was 58% (95% CI 43% to 72%), with substantial heterogeneity (I²=95%) and a wide prediction interval (8-96%), indicating marked between-study variability; this estimate should be interpreted as a descriptive summary of study-level proportions rather than a precise population parameter. CONCLUSIONS: Brain MRI frequently demonstrates dementia-relevant pathology in LMIC clinical cohorts, usually with mixed neurodegenerative-vascular patterns. Structured visual ratings may add aetiologic specificity beyond cognitive screening, but pooled estimates should be interpreted as summaries of heterogeneous study-level findings rather than precise population parameters, given high heterogeneity and risk of bias. PROSPERO REGISTRATION NUMBER: CRD42024510241.
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