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Acute task-related stress activates a bilateral network including the anterior insula and thalamusBrain scans reveal specific neural patterns during moments of stress

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Key Takeaway
Note that acute task-related stress activates a consistent bilateral network including the insula, thalamus, and striatum.

This meta-analysis synthesizes fMRI data to identify the whole-brain neural signature of acute task-related stress. The analysis included 2,810 cases for stress versus control comparisons and 922 cases for control versus stress comparisons. The primary finding is a convergent activation in a bilateral network involving the anterior insula, inferior frontal operculum, dorsal anterior cingulate, supplementary motor area, thalamus, striatum, lateral frontal and parietal cortex, and the left amygdala/parahippocampal gyrus.

In contrast, the analysis identified a single right parahippocampal-amygdala cluster showing decreased activation during stress compared to control conditions. The authors note that the observed pooled convergence may partly reflect neural responses to salience or task demand that are shared across different experimental paradigms.

These findings provide an updated trans-paradigm coordinate-based reference map for stress neurobiology. While the results provide a consistent map of neural activation, clinicians should note that the findings are based on task-based fMRI literature and may be influenced by commonalities in task demands rather than stress alone.

How this fits prior evidence

This meta-analysis provides a neurobiological map of stress responses in the brain. It addresses a gap in identifying consistent neural signatures for acute task-related stress. While it does not directly relate to the previously covered findings regarding physical exercise for sleep, 5-HTTLR polymorphisms, smell testing, climate change, or CRISPR-pharmacogenetics, it contributes to the broader understanding of neurobiology in psychiatric disorders.

When we face a sudden challenge, our brains light up in very specific ways. Researchers analyzed brain scans from over 3,000 people to map out exactly what happens during moments of acute stress. They found a consistent network of areas that activate, including parts of the brain that process emotions and motor movements.

This map shows that stress triggers activity in regions like the thalamus and the amygdala. These areas help the brain react to the world around us. While most of the brain shows increased activity during stress, there is one specific area that actually shows less activity when people are under pressure.

It is important to note that these results come from tasks designed to create stress. Because many of these tasks require a lot of focus, some of the brain activity might be a response to the difficulty of the task itself rather than just the feeling of stress. This map provides a clearer picture for scientists studying how the brain handles pressure.

What this means for you:
Stress activates a consistent network of brain regions, including the amygdala and thalamus.

Common questions

What parts of the brain are affected by stress?

The study found that stress causes increased activity in a large network. This includes the thalamus, striatum, and the amygdala. It also involves areas like the anterior insula and the inferior frontal operculum. These regions work together to help the brain process and react to stressful situations.

Is the brain activity always the same during stress?

While most of the brain shows increased activity during stress, there is one specific area that showed a decrease. This was a single cluster in the right parahippocampal-amygdala region. This means different parts of the brain react in different ways when a person faces a stressful task.

Are these findings always caused by stress?

The results show a clear pattern, but some of the activity might be caused by the difficulty of the task itself. Because the brain has to focus hard on these tasks, it can be hard to tell if the activity is only from stress or also from the mental effort required to finish the task.

Study Details

Study typeMeta analysis
Sample sizen = 2,810
EvidenceLevel 1
PublishedOct 2026
View Original Abstract ↓
Stress is a major risk factor for psychiatric disorders, yet the whole-brain neural signature of acute task-related stress remains incompletely defined, particularly for stress-related decreases in activation. We conducted a PROSPERO-registered systematic review and activation likelihood estimation (ALE) meta-analysis of English-language, peer-reviewed human task-based functional MRI (fMRI) studies published between January 2000 and November 2025. Eligible studies reported whole-brain stereotactic coordinates for stress versus matched non-stress control conditions. Stress > control and control > stress contrasts were analysed separately in GingerALE 3.0.2 using random-effects ALE with cluster-level family-wise error correction. Eighty-nine studies met inclusion criteria. The stress > control analysis included 85 experiments from 84 studies (2,810 participants; 1,350 foci), whereas the control > stress analysis included 25 experiments from 25 studies (922 participants; 263 foci). Stress > control showed convergent activation in a bilateral network including the anterior insula and inferior frontal operculum, dorsal anterior cingulate and supplementary motor area, thalamus, striatum, lateral frontal and parietal cortex, and left amygdala/parahippocampal gyrus. Control > stress yielded a single right parahippocampal-amygdala cluster. Thus, across heterogeneous acute stress-related challenges, the task-based fMRI literature was characterized more by reproducible activation increases across salience, arousal, and action-readiness systems than by consistent deactivation. These findings provide an updated trans-paradigm coordinate-based reference map for stress neurobiology, while acknowledging that the pooled convergence may partly reflect neural responses to salience or task demand that are shared across paradigms.
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