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Home › Conditions › Stress

Stress

19 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Stress

78 trials tracked for Stress: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 17 citations.

78Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Phase 3 1 Phase 2 7 Phase 1 2 Other / NA 66
  1. Phase 4 Stress & Premenstrual Symptoms Study Completed · 17 cited
  2. Phase 4 Efficacy and Tolerability of Combination Varenicline With Hydroxyzine as a Potential Smoking Cessation Treatment Completed
  3. Phase 3 Pilot Study on the Efficacy of Pascoflair in an Acute Stressful Situation (TSST) Completed
  4. Phase 2 Application of Auriculotherapy on Nursing Professional Stress Levels Completed
  5. Phase 2 Personalized Trials for Stress Management Against Standard of Care Completed
  6. Phase 2 Risperidone Treatment for Military Service Related Chronic Post Traumatic Stress Disorder Completed
Show 44 more trials
  1. Phase 2 Auriculotherapy Effectiveness on Stress and Anxiety in Nursing Student Completed
  2. Phase 2 A Behavioral Activation Intervention Administered in a College Freshman Orientation Course Completed
  3. Phase 2 Clinical Trial of the "Living Well With Hearing Loss Workshop" Completed
  4. Phase 2 Autologous Cell Therapy for Stress Urinary Incontinence in Males Following Prostate Surgery Completed
  5. Phase 1 Remote Mindfulness Training Following Early Life Adversity Completed
  6. Phase 1 The Effects of Smell on Mood and Physical Responses Completed
  7. N/A How Easy-to-Follow Exercises Can Help Cancer Patients With Anxiety While Receiving Chemotherapy Completed
  8. N/A Digital Interventions to Treat Hazardous Drinking Completed
  9. N/A Resiliency Programming for Caregivers of Children With Learning and Attentional Difficulties Completed
  10. N/A Examine the Effects of Meditation on Daily Psychological Stress Responses in Woman With a History of Child Adversity Completed
  11. N/A Reintegration: The Role of Spouse Telephone BATTLEMIND Pilot Study Completed
  12. N/A Self-Management Intervention: Considering Needs & Preferences of Dementia Caregivers (Caregiver Career Study) Completed
  13. N/A Mindfulness During COVID-19 Completed
  14. N/A Clinical Trial of a Supporter-Targeted Intervention to Improve Outcomes in Recent Sexual Assault Survivors Completed
  15. N/A Development of a Resiliency Training Program for Parents of Children With Autism Spectrum Disorder Completed
  16. N/A First Responder Resiliency Program During COVID-19 Completed
  17. N/A Tailored Health Self-Management Interventions for Highly Distressed Caregivers: Family Members of Persons With Dementia Completed
  18. N/A Healthcare Providers as Trusted Messengers to Increase Receipt of Tax Credits Among Low-income Families Completed
  19. N/A The Impact of 8 Weeks of Digital Meditation Application and Healthy Eating Program on Work Stress and Health Outcomes Completed
  20. N/A The HARMONY Study: A Intervention to Reduce Cardiometabolic Risk in African American Women Completed
  21. N/A Morning Light Treatment for Traumatic Stress: The Role of Amygdala Reactivity Completed
  22. N/A Brain and Meditation (BAM) Study Completed
  23. N/A A Trauma-Informed Approach for Positive Youth Development for Montana Students Completed
  24. N/A A Trauma-Informed Intervention for Positive Youth Development and Teacher Wellness in Rural Montana Completed
  25. N/A Anxiety and Distress Levels in Women With Suspected Endometrial Cancer Completed
  26. N/A Researching Resiliency in Stressful Experiences (RISE) Program for Men Leaving Incarceration Completed
  27. N/A Exploring the Effects of Muse and Spire on Stress Management Completed
  28. N/A HEALTHY (Health Education Adolescent Leadership Training to Help Youth) Leaders Completed
  29. N/A Breathing Interventions for Relaxation: Dosing Through Extended Exhale Completed
  30. N/A Can Mental Health Chatbots Help Chronic Disease Populations? Completed
  31. N/A Impact of a Financial Success Education Program in Women and Children Completed
  32. N/A Nurse Suicide: Physiologic Sleep Health Promotion Trial Completed
  33. N/A Parenting Young Children Study Completed
  34. N/A Heart Rate Variability and Prematurity Completed
  35. N/A Resilience Training for First Responders in the Opioid Epidemic Completed
  36. N/A Effects of Digital Stories Intervention on Psychosocial Well-being Completed
  37. N/A Stress-reduction Wellness Program for Midlife Black Women (B-SWELL) Completed
  38. N/A Evaluation of the Surgical Pleth Index During Spinal and General Anesthesia Completed
  39. N/A Bundle Consent and Expectation Setting in Pediatric Intensive Care Unit Completed
  40. N/A New Haven MOMS Partnership Completed
  41. N/A Internet and Telephone Support Intervention for Stroke Caregivers Completed
  42. N/A Caring for Providers to Improve Patient Experience Study Phase 2 in Migori County Completed
  43. N/A Intervention Mapping to Adapt a Mindfulness-based Intervention for Adults With Diabetes and Emotional Distress Completed
  44. N/A Ecological Momentary Assessment and Text Message Intervention for Stress Management Completed

Showing the 50 most-cited and recently-updated of 78 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Animal-assisted therapy reduces depression, anxiety, and stress in adults with moderate-to-large effects
Psychiatry Meta-analysis
Animal-assisted therapy reduces depression, anxiety, and stress in adults with moderate-to-large effects Animal assisted therapy reduces anxiety, depression and stress in adults
This meta-analysis of 2391 adults found that animal-assisted therapy (AAT) significantly reduces depression, anxiety, and stress at post-int…
Interacting with animals can significantly lower feelings of anxiety, depression, and stress for adults regardless of their age or gender.
Jul 18, 2026
Portable Digital Nature Experience significantly reduces stress, anxiety, and depression scores
Psychiatry Meta-analysis
Portable Digital Nature Experience significantly reduces stress, anxiety, and depression scores Digital nature experiences help reduce stress, anxiety, and depression
This meta-analysis of 2925 participants across 17 countries found that Portable Digital Nature Experience (PDNE) significantly reduced stres…
Using portable digital nature tools can significantly lower stress and anxiety levels, offering a potential way to find calm when real natur…
Jul 1, 2026
Eco-anxiety shows moderate positive association with depression, anxiety, and stress in young adults
Psychiatry Meta-analysis
Eco-anxiety shows moderate positive association with depression, anxiety, and stress in young adults Strong links found between eco-anxiety and depression, anxiety, and stress in young adults
This systematic review analyzed fifty-nine studies examining eco-emotions among young adults across nations. Researchers found moderate, sig…
A review of fifty-nine studies shows strong links between eco-anxiety and mental health struggles like depression and stress in young adults…
Jun 5, 2026
Brief social media breaks may ease stress and boost well-being in college youth
Psychiatry RCT
Brief social media breaks may ease stress and boost well-being in college youth Digital breaks help college students feel less stressed and anxious for up to three weeks
A meta-analysis of experiments finds that restricting social media use for at least 24 hours reduces depressive symptoms, stress, and anxiet…
Taking a break from social media for 24 hours or more lowers stress and anxiety in college students without causing harm.
medRxiv Jun 3, 2026
Structured exercise cuts depression, anxiety, and stress in university students with large to moderate effects
Primary Care & Family Medicine Meta-analysis
Structured exercise cuts depression, anxiety, and stress in university students with large to moderate effects Structured Exercise Linked to Lower Depression, Anxiety, and Stress in Students
This systematic review and network meta-analysis of 2,127 university students found that structured exercise interventions were associated w…
A large review suggests structured exercise helps university students manage depression, anxiety, and stress better than doing nothing.
Frontiers May 29, 2026
Interventions reduce mental health symptoms in people affected by extreme weather events across multiple studies
Psychiatry Meta-analysis
Interventions reduce mental health symptoms in people affected by extreme weather events across multiple studies Helpful actions reduce mental health problems after extreme weather events for many people
A comprehensive review of thirty-three studies reveals that targeted interventions significantly improve mental health outcomes for individu…
A review of thirty-three studies shows that specific actions help people feel better after disasters. These steps lower stress, sadness, and…
May 29, 2026
Review of intermittent fasting and time-restricted eating effects on stress biology and mental health
Nutrition & Obesity Medicine Sys. Review
Review of intermittent fasting and time-restricted eating effects on stress biology and mental health Intermittent fasting and time restricted eating show mixed results for stress and mental health
This narrative review examines intermittent fasting and time-restricted eating regarding stress biology and mental health. The authors note …
A review of studies on intermittent fasting and time-restricted eating shows mixed results for stress biology and mental health. Effects var…
Frontiers May 7, 2026
High-frequency music therapy reduces stress in adult psychiatric inpatients compared to low-frequency sessions
Psychiatry RCT
High-frequency music therapy reduces stress in adult psychiatric inpatients compared to low-frequency sessions More Music Sessions May Lower Stress in Psychiatric Patients, Study Finds
This randomized controlled trial in 91 adult psychiatric inpatients in Colombia compared high-frequency (five sessions) versus low-frequency…
For patients in short-term psychiatric care, adding more music therapy sessions may help lower stress levels, but it doesn’t seem to improve…
Apr 22, 2026
Narrative review suggests oxytocin signaling modulates sleep, stress, and social interaction in humans and animals
Neurology Sys. Review
Narrative review suggests oxytocin signaling modulates sleep, stress, and social interaction in humans and animals Sleep, Stress, and a New Social Fix
This narrative review examines oxytocin (OT) signaling in human and animal studies regarding sleep regulation, stress physiology, and social…
Oxytocin from positive social contact may help stabilize sleep and lower stress, breaking the vicious cycle that traps many adults.
Frontiers Apr 21, 2026
Meta-analysis suggests VR interventions reduce stress and anxiety in healthcare workers
Primary Care & Family Medicine Meta-analysis
Meta-analysis suggests VR interventions reduce stress and anxiety in healthcare workers Can virtual reality help healthcare workers feel less stressed and anxious right now?
This PRISMA-guided systematic review and meta-analysis pooled 10 studies (493 healthcare workers) examining virtual reality interventions fo…
Virtual reality lowered stress and anxiety scores by 0.64 points for healthcare workers in a new review of 493 participants.
Frontiers Apr 16, 2026
Omega-3 supplementation reduces stress, anxiety, and depression in Saudi adults over three months
Psychiatry RCT
Omega-3 supplementation reduces stress, anxiety, and depression in Saudi adults over three months Omega-3s Help Calm Stress And Improve Sleep
A randomized, double-blind, placebo-controlled trial in 64 Saudi adults found that omega-3 supplementation (500 mg EPA + 250 mg DHA) signifi…
A new trial shows omega-3 supplements significantly reduce stress, anxiety, and depression while improving sleep and memory in people with s…
Apr 15, 2026
Systematic review finds exercise prescription linked to mood, cognition, and stress resilience benefits
Psychiatry Sys. Review
Systematic review finds exercise prescription linked to mood, cognition, and stress resilience benefits Your Workout May Boost Mood Through Your Gut, Not Just Your Brain
A systematic review suggests exercise prescription is associated with advantageous impacts on mood, cognitive function, and stress resilienc…
Daily exercise may lift your mood by changing gut bacteria to produce mood-boosting molecules that signal your brain.
Frontiers Apr 15, 2026

Questions about Stress

Can a 12-week breathwork protocol reduce stress and anxiety in paramedic students?

Yes, a 12-week breathwork protocol significantly reduced stress and anxiety in paramedic students in a randomized controlled trial.

Full answer →
Do anti-inflammatory diets like the Mediterranean diet help reduce stress symptoms?

Yes, anti-inflammatory diets like the Mediterranean diet may help reduce stress symptoms by lowering inflammation, though direct evidence is still emerging.

Full answer →
Can virtual reality interventions help reduce stress and anxiety for healthcare workers?

Yes, a meta-analysis of 10 studies found VR interventions significantly reduce stress and anxiety in healthcare workers, with moderate to large effect sizes.

Full answer →
Does high-frequency music therapy reduce stress better than low-frequency sessions for psychiatric patients?

A 2024 trial found that high-frequency music therapy reduced stress better than low-frequency sessions in adult psychiatric patients, but other research shows various other methods like breathwork and mindfulness also help reduce stress.

Full answer →

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