CFP10 immunohistochemistry shows high sensitivity for renal tuberculosis in surgical specimens
This retrospective cohort study evaluated the diagnostic accuracy of CFP10 immunohistochemical (IHC) staining for renal tuberculosis using 86 surgically resected renal tissue specimens from a single Chinese hospital. The cohort included 49 tuberculosis cases and 37 non-tuberculosis cases (including renal clear cell carcinoma). CFP10 IHC was compared against standard methods: acid-fast staining and real-time fluorescent quantitative polymerase chain reaction (PCR) for Mycobacterium tuberculosis DNA.
The primary results showed CFP10 IHC staining achieved 91.84% sensitivity and 91.89% specificity for diagnosing renal tuberculosis. In comparison, acid-fast staining showed very low sensitivity (4.08%) with perfect specificity (100.00%), while PCR demonstrated 83.67% sensitivity with 100.00% specificity. The study also reported a significant positive association between acid-fast staining results and IHC average optical density values.
Safety and tolerability data were not reported. Key limitations include the retrospective design and single-center setting, which may limit generalizability. The study did not report follow-up data or clinical outcomes beyond diagnostic accuracy.
For clinical practice, these findings suggest CFP10 IHC staining may serve as a supplementary diagnostic method for renal tuberculosis, particularly in cases with negative conventional etiological findings. However, clinicians should interpret these results cautiously given the observational nature and limited setting of the study.
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