Immune dysfunction involving multiple cell types creates an immunosuppressive microenvironment in clear cell renal cell carcinoma
Immune Checkpoint Inhibitors and Immune Dysfunction in Kidney Cancer
This narrative review examines the role of immune dysfunction in clear cell renal cell carcinoma (ccRCC). It identifies how various immune c…
New research highlights how specific immune cells create a protective shield for kidney cancer, potentially making it harder for treatments …
Immune ecotypes may offer more refined patient stratification for ccRCC than current biomarkers
Immune Ecotypes May Guide Kidney Cancer Treatment
This mini review explores the use of immune ecotypes to identify treatment-responsive profiles in patients with advanced clear cell renal ce…
New review proposes four immune subtypes in kidney cancer that could explain why some patients respond to immunotherapy and others don't.
Spontaneous regression observed in a patient with cystic renal cell carcinoma
Kidney tumor shows spontaneous regression before surgery for diagnosis
A case report describes a patient with a cystic mass in the left kidney that exhibited spontaneous regression following an initial period of…
A rare case of kidney cancer showed unexpected shrinking before surgery, highlighting why early intervention is vital for diagnosing complex…
Fianlimab plus cemiplimab showed objective response rates of 20% to 33% in advanced solid tumors during a Phase 1 study.
Early trial shows new cancer drug combo helps some patients with advanced disease
This Phase 1, first-in-human dose-expansion study evaluated fianlimab 1600 mg plus cemiplimab 350 mg in patients with advanced non-small cel…
A new drug combination helped some patients with advanced lung, kidney, head and neck, or skin cancer shrink their tumors in early testing.
ADRB1 and ADRB2 antihypertensive target perturbations associated with increased clear cell renal cell carcinoma risk
Genetic markers linked to blood pressure drugs raise kidney cancer risk
This meta-analysis of Mendelian randomization and colocalization analyses found that genetic perturbations equivalent to antihypertensive dr…
Genetic data suggests certain blood pressure targets may increase clear cell renal cell carcinoma risk, a finding that warrants attention fo…
Angiogenic ccRCC tumors show higher pancreatic metastasis rate in phase II trial
Pancreatic Metastases Predict Better Sunitinib Response in Kidney Cancer
This phase II RCT of 305 treatment-naive ccRCC patients found that angiogenic tumors had a higher rate of pancreatic metastases (21% vs. 6.9…
Kidney tumors with certain genetic patterns are more likely to spread to the pancreas. Patients with these pancreatic metastases respond bet…
Low ipilimumab trough concentration linked to worse progression-free survival in metastatic clear cell renal cell carcinoma
Low Drug Levels Mean Worse Outcomes
This randomized phase 2 trial evaluated nivolumab and ipilimumab trough plasma concentrations in 110 patients with metastatic clear cell ren…
Low levels of a common kidney cancer drug are linked to worse survival outcomes when used with another powerful medicine.
CFP10 immunohistochemistry shows high sensitivity for renal tuberculosis in surgical specimens
New Test Finds Hidden TB in Kidney Tissue
A retrospective cohort study of 86 patients with surgically resected renal tissue found CFP10 immunohistochemical staining had 91.8% sensiti…
A new kidney test spots hidden tuberculosis by finding a specific protein that standard methods often miss, helping doctors catch the infect…
Research across Urologic Neoplasms
Related studies from across the Urologic Neoplasms family.
Low CALLY index is associated with worse progression-free survival and overall survival in renal cell carcinoma
CALLY index helps predict survival for kidney cancer patients
This meta-analysis of five retrospective cohort studies indicates that a low C-reactive protein-albumin-lymphocyte (CALLY) index correlates …
A specific blood marker called the CALLY index may help doctors predict how well patients with kidney cancer will respond to treatment.
Novel TCEB1 variants identified in a case of renal cell carcinoma via NGS and IHC
Single Case Ties Rare TCEB1 Mutation to Kidney Cancer
This case report and literature review describes the identification of two somatic TCEB1 variants in a patient with a left renal mass. The f…
A 52-year-old man's kidney tumor carried a never-before-reported TCEB1 mutation, a finding that may help doctors spot this rare cancer type.
PD-L1 and CTLA-4 Variants Linked to Genitourinary Cancer Risk
Genetic variations linked to risk of certain genitourinary cancers
A meta-analysis of 16 studies links PD-L1 and CTLA-4 variants to altered genitourinary cancer susceptibility, especially in Asian population…
Specific genetic markers in the PD-L1 and CTLA-4 genes are linked to different levels of risk for bladder, kidney, and prostate cancers.
Hugo RAS system shows no significant difference from other platforms in partial nephrectomy for renal cell carcinoma
Hugo RAS system shows similar results to other kidney surgeries
This meta-analysis of observational studies evaluates the Hugo RAS system compared to the da Vinci platform and traditional laparoscopy for …
A new surgical robot platform shows similar safety and recovery results to traditional methods for kidney cancer surgery.
PFS and ORR fall short as OS surrogates in metastatic RCC
Analysis shows limitations in using certain metrics to predict cancer survival
In metastatic RCC, PFS and ORR show only moderate correlation with OS, with surrogate thresholds that are not statistically significant.
A large analysis of kidney cancer cases suggests that common clinical markers may not reliably predict how long a patient will live.
Pazopanib and Axitinib Linked to Probable Cholecystitis in Renal Cell Carcinoma Case
Kidney cancer drugs may cause gallbladder inflammation in some patients
This case report and literature review describes a 74-year-old man with renal cell carcinoma who developed cholecystitis 4 weeks after start…
A 74-year-old man developed gallbladder inflammation after taking two specific drugs for kidney cancer, highlighting a need for closer monit…
Sutureless renorrhaphy is noninferior to conventional renorrhaphy for trifecta achievement in robot-assisted partial nephrectomy
Sutureless Technique Shows No Difference in Renal Cancer Surgery
This meta-analysis of 787 patients evaluated sutureless renorrhaphy versus conventional renorrhaphy in robot-assisted off-clamp partial neph…
A sutureless technique for closing the kidney during surgery shows similar results to traditional methods for patients with renal cancer.
Belzutifan and Lenvatinib Combination Improves Progression Free Survival in Advanced Renal Cell Carcinoma
Trial shows new drug combo slows advanced kidney cancer growth
A Phase 3 trial demonstrates that the belzutifan-lenvatinib combination significantly extends progression-free survival in patients with adv…
A new drug combination helped slow the growth of advanced kidney cancer in patients who did not respond to earlier treatments.
First-line immune checkpoint inhibitors plus anti-angiogenic therapy improve progression-free survival and response rates in advanced RCC
Combination Therapy Shows Better Outcomes for Advanced Renal Cell Carcinoma
This meta-analysis of 4,977 patients found that first-line immune checkpoint inhibitors combined with anti-angiogenic therapy significantly …
A new combination of immune checkpoint inhibitors and anti-angiogenic therapy shows better survival rates than standard treatment for advanc…
cGAS-STING pathway activation drives inflammation, fibrosis, and podocyte injury in various kidney diseases
New research identifies a key pathway in kidney disease progression
This systematic review synthesizes preclinical data on the cGAS-STING signaling pathway's role in acute kidney injury, chronic kidney diseas…
A specific signaling pathway called cGAS-STING acts as a central hub, linking inflammation and metabolism to several types of serious kidney…
Comparative Efficacy of Robot Assisted Radical Nephrectomy and Open Surgery for IVC Thrombus
Robot assisted surgery shows fewer complications for certain kidney cancers
Meta-analysis indicates robot-assisted radical nephrectomy reduces blood loss, transfusion needs, and major complications in patients with r…
Robotic surgery may reduce blood loss and hospital stays for patients with specific types of kidney cancer involving the inferior vena cava.
FH-deficient renal cell carcinoma case shows rapid bone metastasis despite adjuvant therapy
Rare Kidney Cancer Case Shows Aggressive Spread Despite Treatment
This case report and literature review describes a 42-year-old woman with FH-deficient renal cell carcinoma and uterine leiomyomas, treated …
A rare kidney cancer in a 42-year-old woman spread quickly despite surgery and therapy, highlighting the need for early genetic testing.
Questions about Renal Clear Cell Carcinoma
Can a cystic mass in Renal Clear Cell Carcinoma shrink on its own?
Yes, a cystic mass in renal clear cell carcinoma can shrink on its own, but this is extremely rare and does not replace the need for surgical treatment.
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