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Spontaneous uterine rupture occurred in seven women with median gestational age of 27 weeks.

Spontaneous uterine rupture occurred in seven women with median gestational age of 27 weeks.
Photo by Europeana / Unsplash
Key Takeaway
Note that spontaneous uterine rupture occurred in 57.1% of cases during the second trimester in this small series.

This retrospective case series reports on seven women who experienced spontaneous complete uterine rupture during the second or third trimester of pregnancy. The study population consisted of these seven cases, with no comparator group or control cohort included in the analysis.

Demographic and clinical data revealed a median maternal age of 30 years. The median gestational age at the time of rupture was 27 weeks. Among the seven cases, four women (57.1%) experienced rupture during the second trimester. The remaining cases occurred in the third trimester.

Secondary outcomes assessed included maternal and fetal outcomes, risk factors, clinical features, gestational age at rupture, clinical presentation, and management strategies. Specific details regarding fetal outcomes, management protocols, and long-term follow-up were not reported in the available data. No adverse events, serious adverse events, or discontinuations were documented.

Key limitations of this study include its small sample size of seven patients and its retrospective case series design. These factors limit the ability to draw causal conclusions or generalize findings to broader populations. The study setting was not reported, and funding sources or potential conflicts of interest were not disclosed. Consequently, these findings should be interpreted cautiously and used primarily to inform early warning signs and emergency intervention strategies in clinical practice rather than to establish definitive risk profiles or treatment guidelines.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
ObjectiveTo summarize the clinical features, risk factors, and maternal and fetal outcomes of spontaneous complete uterine rupture during the second and third trimester of pregnancy, and to explore key aspects of early identification and management, especially in cases without prior cesarean section. This study aims to provide evidence-based insights for early warning and emergency intervention in clinical practice.MethodsThis is a retrospective case series analysis of seven cases of spontaneous complete uterine rupture occurring in the second and third trimester of pregnancy. We analyzed patient demographics, obstetric history, gestational age at rupture, clinical presentation, management strategies, and outcomes. Descriptive statistical methods were employed, with continuous variables expressed as medians (range) and categorical variables as frequencies (percentages).ResultsThe median age of the seven women was 30 years old, with a median gestational age at rupture of 27 weeks. Among them, 57.1% (4/7) experienced rupture in the second trimester (
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