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Review of giant endometrial polyps in 15 postmenopausal women without hormonal exposure

Review of giant endometrial polyps in 15 postmenopausal women without hormonal exposure
Photo by Alex Gruber / Unsplash
Key Takeaway
Note that TVS is first-line evaluation, while diagnostic hysteroscopy remains the gold standard for giant endometrial polyps.

This source is a case report and literature review focusing on giant endometrial polyps in postmenopausal women without hormonal exposure. The review includes data from 15 patients, with ages ranging from 55 to 70 years. Polyp diameters were reported between 4.0 and 12.0 cm, and the most common symptom was postmenopausal bleeding (PMB). Histological findings indicated that 11 of the 15 polyps were benign and exhibited cystic dilatation.

The authors detail the distribution of surgical interventions, noting that six patients underwent hysteroscopic polypectomy, eight received total abdominal hysterectomy with bilateral salpingo-oophorectomy (TAH-BSO), and one underwent dilation and curettage (D&C). Safety data, including adverse events or discontinuations, were not reported in this source. The review does not provide pooled effect sizes or confidence intervals as it is not a meta-analysis.

Regarding practice relevance, the authors state that transvaginal sonography (TVS) is the first-line modality for initial evaluation. Diagnostic hysteroscopy with complete polypectomy remains the gold standard, enabling accurate histopathological assessment and avoiding unnecessary hysterectomy. The authors acknowledge that the setting was not reported and that this evidence is limited to a small number of cases.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedApr 2026
View Original Abstract ↓
ObjectiveGiant endometrial polyps (EPs) are rare in postmenopausal women without hormonal exposure. This study aimed to summarize their clinical presentation and management.PatientFifteen postmenopausal women with primary giant EPs were included: one case from our center and fourteen additional cases were retrieved from Pubmed, Web of science and Embase databases.ResultsThe fifteen patients ranged in age from 55 to 70 years, with polyp diameters ranging from 4.0 to 12.0 cm. The most common symptom was postmenopausal bleeding (PMB). Surgical intervention was performed in all cases: six patients underwent hysteroscopic polypectomy, eight received total abdominal hysterectomy with bilateral salpingo-oophorectomy (TAH-BSO) and one underwent dilation and curettage D&C. Most polyps (11/15) were benign on histology and exhibited cystic dilatation.ConclusionGiant EPs in postmenopausal women are rare but predominantly benign, especially in the absence of hormonal exposure. Transvaginal sonography (TVS) is the first-line modality for initial evaluation. Diagnostic hysteroscopy with complete polypectomy remains the gold standard, enabling accurate histopathological assessment and avoiding unnecessary hysterectomy.
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