Lipoprotein(a) concentrations associate with coronary artery disease severity in single-center observational cohort of 238 adults.

This single-center observational cohort study evaluated 238 adults (mean age 65.1 ± 0.6 years; 60% male) referred for elective coronary angiography in Kazakhstan. The primary exposure involved Lipoprotein(a) [Lp(a)] concentrations assessed via fasting venous blood samples. The study aimed to determine the relationship between Lp(a) concentrations and coronary artery disease severity.

Participants were categorized into coronary artery disease (CAD) severity groups including no significant stenosis, 1-vessel, 2-vessel, and ≥3-vessel disease. Prevalence of significant CAD was 185 patients (78%), while 53 (22%) had no obstructive disease. Lp(a) levels increased stepwise with CAD severity: 36.5 ± 9.4 nmol/L (no stenosis), 45.3 ± 9.0 nmol/L (1-vessel), 76.7 ± 14.6 nmol/L (2-vessel), and 97.2 ± 15.8 nmol/L (≥3-vessel disease).

Safety data regarding adverse events, serious adverse events, or discontinuations were not reported in this publication. Key limitations include the single-center setting which may limit generalizability and the observational design where association does not imply causation. Furthermore, the abstract text was truncated at the p-value, preventing full statistical assessment of significance. The practice relevance involves determining an Lp(a) threshold associated with obstructive coronary disease in Central Asia. Clinicians should interpret these findings cautiously given the study design constraints and incomplete statistical reporting in this region.