Posterior precortical vitreous pocket associated with greater retinal thickness in 47 of 65 healthy subjectsA glass pocket in the eye is linked to thicker retinal tissue in healthy older adults

A prospective single-center study assessed macular retinal thickness, volume, and vessel density in 65 healthy subjects. The population was divided into a PPVP-positive group and a PPVP-negative group. Among the 65 subjects, 47 had PPVP.

The primary outcome measured retinal thickness in the superior inner macula. Results showed that thickness was significantly greater in the PPVP-positive group compared with the PPVP-negative group. The mean thickness was 362.91 ± 16.84 µm for the PPVP-positive group versus 344.06 ± 15.59 µm for the PPVP-negative group. The difference was statistically significant with a p-value less than 0.05.

Safety and tolerability data were not reported, as no adverse events, serious adverse events, discontinuations, or specific tolerability metrics were captured in the study. The study design was prospective and single-center, which may limit generalizability. Because the participants were healthy subjects, the clinical relevance for patients with retinal disease remains uncertain. The study does not establish a causal link between PPVP and retinal thickening.