Thymectomy and immunotherapy improve symptoms in a patient with myasthenia gravis and paraneoplastic syndrome
Rare Nerve Damage Tied to Thymoma Improves After Treatment
This case report and literature review describes a 53-year-old male with myasthenia gravis, invasive thymoma, and CRMP5/CV2 antibody-positiv…
A 53-year-old man with myasthenia gravis and a rare paraneoplastic nerve syndrome improved after thymectomy and immunotherapy.
Expert consensus provides a framework for harmonizing HLH diagnosis and management in GCC countries
Experts Reach Consensus on Managing Hemophagocytic Lymphohistiocytosis
This consensus study utilizes a modified Delphi approach to establish management guidelines for hemophagocytic lymphohistiocytosis (HLH) in …
Experts in the Gulf region have agreed on new guidelines to help doctors identify and treat the rare condition HLH more effectively.
Cow's milk consumption supports physical growth, bone health, and cognitive performance in healthy children
Cow's Milk Offers Growth and Bone Benefits for Children
This expert review of 70 publications examines the safety and benefits of cow's milk consumption in children and adolescents. The authors co…
Cow's milk provides important nutrients for bone health and physical growth in children who do not have a milk allergy or lactose intoleranc…
Biologics provide effective and long-lasting disease control for chronic rhinosinusitis with nasal polyps
Biologics May Help Chronic Sinusitis With Nasal Polyps
This narrative review examines the efficacy of biologics, including dupilumab, mepolizumab, omalizumab, and tezepelumab, for patients with c…
A new review suggests biologic drugs may improve sinus symptoms, smell, and asthma in people with nasal polyps.
B-cell targeted therapies show durable immune responses in pemphigus vulgaris and myasthenia gravis
New data shows how B-cell therapies treat autoimmune diseases
This systematic review of 24 clinical trials involving more than 3,500 participants evaluates B-cell targeted therapies for various autoimmu…
New research highlights how targeting specific immune cells can provide lasting relief for several different autoimmune conditions.
MMR status-guided immunotherapy provides favorable cost-effectiveness and quality-adjusted survival in dMMR/MSI-H endometrial cancer
MMR Testing Helps Identify High Value Treatment for Endometrial Cancer
This mini review examines the economic value of mismatch repair (MMR) status-guided immunotherapy for advanced and recurrent endometrial can…
Testing for mismatch repair status helps doctors identify which patients with advanced endometrial cancer may benefit most from specific imm…
Mitophagy acts as a core barrier to effective immunotherapy in melanoma and other skin cancers
Mitophagy acts as a barrier to skin cancer immunotherapy
This narrative review explores how mitophagy functions as a barrier to immunotherapy in melanoma, cutaneous squamous cell carcinoma, and bas…
A cellular process called mitophagy may help skin cancers hide from the immune system, making it harder for certain treatments to work.
Add-on therapies fail to beat placebo in cutaneous sarcoidosis, but quality of life may improve
Corticosteroids Show Limited Success for Skin Sarcoidosis Treatment
This meta-analysis of 156 adults with cutaneous sarcoidosis found that pharmacological add-on therapies did not significantly improve clinic…
New analysis suggests that adding extra medications to corticosteroid treatment for skin sarcoidosis may not improve clinical results for pa…
Autoantibody positivity and false-negative cytology can mask invasive mucinous adenocarcinoma in patients with IPAF
Lung cancer can mimic autoimmune lung disease in some patients
This case report describes a 78-year-old female with invasive mucinous adenocarcinoma and interstitial pneumonia with autoimmune features. T…
A new case shows how a rare lung cancer can look like an autoimmune disease, making it hard for doctors to tell them apart.
Several risk factors including early-life antibiotic use and maternal OCP exposure increase allergic rhinitis risk
Several Risk Factors Linked to Children with Allergic Rhinitis
This umbrella review of systematic reviews and meta-analyses synthesizes evidence regarding 75 risk factors for pediatric allergic rhinitis.…
New research identifies various factors, like early-life antibiotic use and air pollution, that are linked to a higher risk of allergic rhin…
Structured clinical data models show moderate discrimination for predicting relapsing multiple sclerosis outcomes
New Models Show Potential for Predicting Multiple Sclerosis Relapses
This systematic review evaluates models for predicting relapse-related outcomes in patients with relapsing multiple sclerosis. Models based …
New models using clinical data show promise in predicting multiple sclerosis relapses, though more consistent testing is needed for daily us…
HLA-B alleles B*39:01, B*13:01, and B*38:02 serve as markers for sulfasalazine-induced SCARs in Asian populations
Genetic markers help predict severe reactions to sulfasalazine medication
This meta-analysis of a multicountry genetic study identifies specific HLA-B alleles as markers for sulfasalazine-induced severe cutaneous a…
New research identifies specific genetic markers that can help predict if patients with arthritis will have a severe skin reaction to sulfas…