Periostin correlates with advanced clinical stage and poor prognosis in multiple solid tumor types
Protein called Periostin may drive growth in many cancer types
This systematic review examines the role of Periostin (OSF-2) across various malignancies including lung, breast, and gastric cancers. The r…
A protein called Periostin may help tumors grow, spread, and hide from the immune system in several types of cancer.
Epigenetic mechanisms regulate T-cell differentiation and activity in the pathogenesis of autoimmune diseases
Epigenetic mechanisms drive T-cell activity in autoimmune diseases
This mini review explores how epigenetic mechanisms, including DNA methylation and chromatin architecture, regulate T-cell behavior in autoi…
New research explores how chemical changes to DNA and proteins control the immune cells that drive autoimmune diseases.
Obesity-induced neuroinflammation and neuroimmunometabolic feedback may reshape the tumor microenvironment in cancer patients
Obesity and Neuroinflammation May Influence How Cancer Progresses
This narrative review explores the obesity-neuroinflammation-cancer axis as a framework for how metabolic and inflammatory signals perturb n…
New research explores how obesity and inflammation in the nervous system might change the environment where tumors grow and respond to treat…
Intralesional corticosteroid combination therapy shows odds ratio of 2.71 for improved keloid outcomes
Combining treatments may improve results for patients with keloids
This meta-analysis of keloid treatments found that combination therapy with intralesional corticosteroids and other agents yielded an odds r…
Combining corticosteroids with other treatments like 5-fluorouracil may offer better results and safety for people living with keloids.
MRSE Brain Abscess After Stent-Assisted Coiling for Ruptured Aneurysm Treated With Drainage
Treatment Strategy for Rare Brain Abscess After Aneurysm Surgery
Single case report and literature review describing a 49-year-old man who developed a methicillin-resistant Staphylococcus epidermidis (ST2)…
A case report describes a specific treatment path for a patient who developed a rare brain abscess following a procedure for a ruptured aneu…
Biologics reduce severe asthma exacerbation rates in meta-analysis of 6 RCTs and a case-series
Biologics Show Significant Reduction in Severe Asthma Exacerbation Rates
This meta-analysis of 6 RCTs and a self-controlled case-series evaluates the impact of biologics on severe asthma exacerbation rates. The an…
New analysis shows that biologics significantly reduce severe asthma flare-ups, especially for patients with specific markers like high eosi…
Monocyte and macrophage sensing of calciprotein particles triggers inflammasome activation and interleukin-1β release
Immune Cells and Calcium Particles May Drive Damage in Kidney Disease
This mini-review synthesizes evidence regarding how monocytes and macrophages respond to calciprotein particles (CPPs). The review details m…
New research shows how certain immune cells react to calcium particles, potentially causing inflammation and tissue damage in kidney patient…
Specific microRNAs including miR-338-3p and miR-155-5p serve as robust biomarkers for active pemphigus disease
Specific MicroRNAs Show Promise as Biomarkers for Pemphigus Disease
This systematic review synthesizes evidence on microRNA expression profiles in pemphigus patients and experimental models. The review identi…
Specific microRNAs like miR-338-3p and miR-155-5p show strong potential as tools to help identify and track the severity of pemphigus.
Immune and chondrocyte ligand-receptor axes drive osteoarthritis progression and offer therapeutic targets
Scientists Map Immune Signals That May Drive Knee Arthritis
This narrative review examines immune-chondrocyte ligand-receptor (LR) axes in osteoarthritis, identifying cytokine, chemokine, DAMP-PRR, an…
A new review maps the immune signals that may push cartilage cells to break down in osteoarthritis, pointing to possible future treatment ta…
Voriconazole used for rare Scedosporium aurantiacum keratitis in a single 80-year-old patient
Rare Fungal Eye Infection Treated With Voriconazole in 80-Year-Old
This is a single-patient case report and review describing Scedosporium aurantiacum keratitis in an 80-year-old woman treated with topical a…
An 80-year-old woman's corneal infection turned out to be a rare fungus, Scedosporium aurantiacum, treated with voriconazole eye drops and p…
suPAR predicts incident CKD and ESKD in adults with preserved kidney function
suPAR Levels May Predict Risk of Chronic Kidney Disease
This systematic review of 31,416 patients found that suPAR predicts incident CKD (OR 3.13) and ESKD (HR 1.53) in adults with preserved kidne…
A large review suggests that suPAR levels can help predict the risk of developing chronic kidney disease and end-stage kidney disease in som…
Viral infections in the tumor immune microenvironment modulate immune cell functions and cytokine networks
Viral Infections in Tumors Impact Cancer Immune Responses
This systematic review examines the impact of viral infections within the tumor immune microenvironment. The authors synthesize how viruses …
Viral infections within the tumor environment can change how the immune system reacts to cancer and may impact the success of certain immuno…