Proposed CTS protocol aims to convert cold tumors to hot and improve immunotherapy response
New Strategy Aims to Turn Cold Tumors Hot for Treatment
This systematic review proposes a phased anti-hallmark Combinations, Timing, and Sequencing (CTS) protocol involving vascular normalization,…
A new strategy aims to change the environment around tumors to make them more responsive to immunotherapy and better respond to treatment.
Succinate accumulation drives inflammatory and immune dysregulation in rheumatoid arthritis through three distinct pathways
Succinate drives inflammation in rheumatoid arthritis, review finds
This systematic review examines the molecular mechanisms of succinate accumulation and its role in rheumatoid arthritis (RA). The authors id…
A new review reveals how succinate, a natural molecule, fuels inflammation in rheumatoid arthritis, pointing to new drug targets.
Immune ecotypes may offer more refined patient stratification for ccRCC than current biomarkers
Immune Ecotypes May Guide Kidney Cancer Treatment
This mini review explores the use of immune ecotypes to identify treatment-responsive profiles in patients with advanced clear cell renal ce…
New review proposes four immune subtypes in kidney cancer that could explain why some patients respond to immunotherapy and others don't.
Calcium signaling dysregulation drives keratinocyte defects and immune activation in psoriasis
Calcium signaling problems may drive the cycle of psoriasis
This systematic review synthesizes evidence that impaired calcium sensing and SOCE dysfunction in keratinocytes, alongside persistently acti…
New research identifies how faulty calcium signals in skin cells and immune cells could be a key driver of psoriasis symptoms.
m6A modification regulates renal tubular epithelial cell fate and inflammatory responses in acute kidney injury
Gene modification may drive kidney injury, review finds
This systematic review examines the role of N6-methyladenosine (m6A) modification in the progression of acute kidney injury. The authors con…
A new review reveals that a chemical modification to RNA, called m6A, plays a key role in acute kidney injury by affecting cell death and in…
Scavenger receptor-guided and cathepsin B-triggered nanodelivery systems enable targeted macrophage remodeling for atherosclerosis and cancer
New nanodelivery systems target macrophages to treat cancer and atherosclerosis
This narrative review explores the use of scavenger receptor-guided and cathepsin B-triggered nanodelivery systems to target macrophages in …
Scientists are developing smart nanocarriers that use specific cellular triggers to deliver medicine directly to diseased cells in the heart…
HMGB1 and LPS interactions provide potential therapeutic targets for inflammation and coagulation in sepsis
New research identifies how specific proteins drive sepsis inflammation
This narrative review explores the mechanistic roles of Lipopolysaccharide (LPS) and High Mobility Group Box 1 (HMGB1) in sepsis. The author…
Scientists have identified a specific interaction between two molecules that triggers severe inflammation and organ failure during sepsis.
Higher systemic immune-inflammation index values are associated with patients diagnosed with rheumatic diseases
New marker shows inflammation levels in rheumatic disease patients
This meta-analysis of 6,903 patients with rheumatic diseases and 6,724 healthy controls found significantly higher systemic immune-inflammat…
A new way to measure immune activity could help doctors better identify and monitor people living with rheumatic diseases.
FDA Approves Children's Zyrtec Hives (cetirizine) for Hives Relief
FDA approves Children's Zyrtec Hives for itching and hives relief.
The FDA approved Children's Zyrtec Hives (cetirizine) for reducing hives and relieving itching due to urticaria. The product is not intended…
The FDA approved Children's Zyrtec Hives (cetirizine) to relieve hives and itching. It is for ages 6 and older. This drug treats symptoms bu…
FDA Approves Tuxarin Er (codeine/chlorpheniramine) for Cough and Upper Respiratory Symptoms
FDA approves new cough medicine Tuxarin Er for adults only.
The FDA approved Tuxarin Er (codeine/chlorpheniramine) for temporary relief of cough and upper respiratory symptoms due to allergy or common…
The FDA approved Tuxarin Er for adults 18 and older to relieve cough and cold symptoms. It combines codeine and chlorpheniramine. This does …
Immune checkpoint inhibitors are associated with acute kidney injury and multi-organ immune-related adverse events
Immune checkpoint inhibitors linked to kidney and heart risks
This narrative review synthesizes evidence from 68 studies involving 15,392 participants regarding the safety of immune checkpoint inhibitor…
New data shows that certain cancer treatments can cause serious side effects like kidney damage and heart inflammation.
Primary and acquired resistance to immune checkpoint inhibitors in NSCLC involves antigen presentation and TME remodeling
Understanding why some lung cancer treatments do not work for every patient
This systematic review synthesizes mechanisms of primary and acquired resistance to PD-1/PD-L1 inhibitors in patients with non-small cell lu…
Doctors are studying why certain immune-boosting drugs fail to stop lung cancer growth. New insights help find better ways to treat patients…