Multispecies animal models often fail to reflect human nasal sinus anatomy and physiology in chronic rhinosinusitis research
Scientists compare different animal models for studying human nose diseases to find better ways to test new treatments
This narrative review examines the efficiency of murine, sheep, and porcine models in representing human phenotypes for chronic rhinosinusit…
Researchers looked at mice, sheep, and pigs to see which ones best match human nose conditions. They found that simple models often fail to …
Prenatal beta-2-adrenergic agonist exposure linked to increased ASD risk with aOR 1.34 preconception
Prenatal asthma drug use linked to higher autism risk in massive study
This systematic review and meta-analysis evaluated neurodevelopmental outcomes in offspring of pregnant women exposed to asthma medications.…
A huge analysis of millions of births found a link between taking asthma inhalers before or during pregnancy and autism in children.
Follicular T cell subsets and tertiary lymphoid structures may guide immunotherapy in ovarian cancer
New immune targets offer hope for ovarian cancer patients
This narrative review synthesizes evidence on follicular T cell subsets, tertiary lymphoid structures, and other immune features in ovarian …
A review highlights new immune system features that could help doctors predict treatment success and find better ways to fight ovarian cance…
PD-1/PD-L1 inhibitors plus chemotherapy improve survival in advanced endometrial cancer
Immunotherapy combo extends life in advanced endometrial cancer
A meta-analysis of 4,052 patients from RCTs found that adding PD-1/PD-L1 inhibitors to chemotherapy improved overall survival (median 43.7 v…
Adding immunotherapy to chemo boosted survival by over 14 months in advanced endometrial cancer, a new analysis finds.
Extracellular vesicle signalling may participate in postoperative neurocognitive disorder progression in older surgical patients
Scientists explore how stress signals might worsen brain recovery after surgery
This review examines extracellular vesicle signalling as a potential mechanism in perioperative neurocognitive disorders among older and vul…
Current evidence suggests multiple factors drive brain issues after surgery, but exactly how stress signals cause lasting problems remains u…
Epstein–Barr virus infection shows higher seropositivity and viral loads in systemic lupus erythematosus patients compared to healthy controls
Epstein-Barr virus linked to lupus in new review of patient data
A mini review highlights that Epstein–Barr virus infection is more prevalent and active in patients with systemic lupus erythematosus than i…
A new review finds that Epstein-Barr virus is more common and active in lupus patients, suggesting a role in the disease.
Tertiary lymphoid structures represent a promising but context-dependent biomarker and potential therapeutic intermediate in breast cancer
Tertiary lymphoid structures may help predict breast cancer outcomes but need clearer definitions
This narrative review discusses the role of tertiary lymphoid structures (TLS) in breast cancer. The authors note that TLS biological and cl…
Tertiary lymphoid structures might predict breast cancer outcomes, yet their meaning varies too much for simple yes or no labels to work wel…
Immune checkpoint inhibitors appear safe in cancer patients with pre-existing sarcoidosis
Most cancer patients with sarcoidosis stay safe on immune checkpoint inhibitor therapy
A meta-analysis examined immune checkpoint inhibitor use in cancer patients with documented pre-existing sarcoidosis. Most patients showed n…
A look at 43 patients shows most do not have a flare when taking immune checkpoint inhibitors, though some do experience a flare.
Chronic HCV infection drives T cell dysfunction, regulatory T cell accumulation, and metabolic defects that persist after viral clearance
Immune defects in hepatitis C may last after the virus is gone
This narrative review examines immune mechanisms in patients with chronic hepatitis C virus infection. The authors describe how prolonged an…
A review explains how chronic hepatitis C causes lasting immune changes that persist even after the virus is cleared, suggesting new treatme…
Botulinum toxin type A improves nasal symptoms in refractory allergic rhinitis with SMD -2.07 at 4 weeks
Botox helps stubborn nasal allergies, review finds
This meta-analysis of 187 patients with refractory allergic rhinitis found that botulinum toxin type A significantly improved total nasal sy…
For people with nasal allergies that won't quit, a review suggests Botox shots may ease symptoms as well as standard steroid injections or p…
Transitioning from static TNM staging to a multidimensional, adaptive treatment model integrating genomics and immunology for HPV-associated OPSCC
Doctors are shifting from static staging to adaptive care for HPV throat cancer
This narrative review discusses the evolving management of HPV-associated oropharyngeal squamous cell carcinoma. The authors argue for trans…
Medical teams are moving away from old staging rules toward a new model that uses genomics and immunology for precise care.
Antibody-based therapies offer potential efficacy and durability options for relapsed refractory acute myeloid leukemia patients
Review explores antibody therapies for relapsed acute myeloid leukemia
This narrative review examines antibody-based therapies for relapsed or refractory acute myeloid leukemia. The authors discuss potential eff…
A review looks at antibody-based therapies for patients with relapsed acute myeloid leukemia, comparing them to traditional treatment option…