scFv-based biologics show potential for immunomodulation in type 1 and type 2 diabetes
Review explores scFv biologics for Type 1 and Type 2 diabetes care
This narrative review explores the potential of single-chain variable fragment (scFv)-based biologics for treating type 1 and type 2 diabete…
This review looks at scFv-based biologics for diabetes. It discusses how these treatments might help with immune control and blood sugar bal…
Periodontitis and chronic liver disease linked through proposed oral-gut-liver axis
Conceptual framework links liver, gut, immune, and oral health
This narrative review proposes a Liver-Gut-Immune-Oral Axis linking periodontitis and chronic liver disease. The authors synthesize mechanis…
A narrative review suggests a conceptual link between liver disease and oral health, though this biological system needs direct experimental…
Biologic and targeted synthetic DMARDs show reassuring malignancy safety in inflammatory arthritides, but non-melanoma skin cancer risk rises with TNF inhibitors
Biologics for arthritis: Cancer risk appears low overall
This narrative review of biologic and targeted synthetic DMARDs in immune-mediated inflammatory arthritides finds most therapies have reassu…
Most biologic arthritis drugs don't raise overall cancer risk, but skin cancer risk may be higher with some.
Ultrasound-driven mechanical immunomodulation shows promise for tumor therapy but faces key hurdles
Early review finds ultrasound may help tumors but safety needs more study
This narrative review examines ultrasound-driven mechanical immunomodulation as a tumor therapy. The authors synthesize evidence that mechan…
A new review suggests ultrasound-driven mechanical immunomodulation could affect tumors, though dosimetry standardization and targeting accu…
Narrative review discusses cerebral small vessel disease without reporting specific interventions or outcomes
Narrative review offers perspective on cerebral small vessel disease
This narrative review addresses cerebral small vessel disease but does not report specific interventions, comparators, or outcomes. The auth…
A narrative review discusses cerebral small vessel disease without reporting new clinical data or specific treatment outcomes.
Combining immunoglobulins and cytokine levels could predict allergen-specific immunotherapy effectiveness
Biological markers may help predict allergen immunotherapy success
This narrative review examines predicting the effectiveness of allergen-specific immunotherapy (AIT) for allergic diseases. The authors sugg…
A review suggests combining immunoglobulins and cytokine levels could predict allergen immunotherapy effectiveness and guide therapy for all…
Chemo-immunotherapy yields 12-month disease-free status in rare triple-negative neuroendocrine breast cancer
A single patient remains disease-free after a new chemo-immunotherapy approach for rare breast cancer
This case report describes a 71-year-old woman with triple-negative neuroendocrine breast cancer treated with paclitaxel, cisplatin, and pem…
A 71-year-old woman with rare breast cancer stayed disease-free for a year using a combination of chemotherapy and immunotherapy that doctor…
Combination therapy with 3M-052 and anti-TNFR2 antibody suppressed colon cancer growth in mouse models while enhancing immune response
Early mouse study links antibody combo to slowed colon cancer growth
A preclinical study using colon cancer mouse models found that combining 3M-052 with an anti-TNFR2 antibody significantly suppressed tumor g…
A preclinical mouse study suggests a specific antibody combination may slow colon cancer growth by boosting immune cells.
HLA-DPA1 and HLA-DPB1 expression is downregulated in pediatric asthma with high diagnostic value
New guideline reveals molecular changes in pediatric asthma cells
This guideline presents a multi-level integrated transcriptomic analysis of pediatric asthma. The authors report significantly downregulated…
A new guideline shows specific immune cells in children with asthma are underactive and stressed, offering clues for future treatments.
Erratum published for vaccine recommendations report
What does a vaccine report correction mean for you?
An erratum notice has been published for a report on vaccine recommendations. No study details, population, or findings are provided in this…
A correction notice for a vaccine report simply fixes an error in the published record and does not add new facts or change vaccination reco…
Glycolysis-centered understanding of ovarian cancer may support biomarker-guided combination strategies and improve translational therapeutic design
New review suggests metabolic pathways in ovarian cancer need better tools to treat
This narrative review explores glycolysis-centered understanding of ovarian cancer. The authors suggest this perspective may support biomark…
A fresh look at ovarian cancer metabolism shows current tools are too limited to guide effective combination therapies for patients.
Multispecies animal models often fail to reflect human nasal sinus anatomy and physiology in chronic rhinosinusitis research
Scientists compare different animal models for studying human nose diseases to find better ways to test new treatments
This narrative review examines the efficiency of murine, sheep, and porcine models in representing human phenotypes for chronic rhinosinusit…
Researchers looked at mice, sheep, and pigs to see which ones best match human nose conditions. They found that simple models often fail to …