Tumor immune microenvironment heterogeneity between thyroid and colorectal cancer drives distinct immune evasion mechanisms
Thyroid and colorectal cancers differ in immune environment
This systematic review compares the tumor immune microenvironment (TIME) in thyroid cancer and colorectal cancer. The authors find marked he…
Thyroid and colorectal cancers show distinct immune microenvironments, which may affect how they respond to immunotherapy.
Perioperative and postoperative immunotherapy timing determines clinical outcomes in locally advanced head and neck squamous cell carcinoma
Timing of immunotherapy affects outcomes for head and neck cancer
This narrative review examines the impact of immunotherapy sequencing on patients with locally advanced head and neck squamous cell carcinom…
The timing of immunotherapy treatment significantly changes how well it controls local and distant spread in head and neck cancer.
Comprehensive-component subcutaneous immunotherapy shows the most favorable symptom score reduction in allergic rhinitis
Comprehensive Immunotherapy Shows Best Results for Allergic Rhinitis Symptoms
This network meta-analysis of 7,329 participants evaluated three types of house dust mite allergen immunotherapy for allergic rhinitis. CC-S…
A large review of over 7,000 patients suggests that comprehensive subcutaneous immunotherapy may offer the strongest relief for allergic rhi…
Erythrocytes function as immunomodulatory participants and potential drivers of pathology in post-traumatic environments
Red blood cells play a key role in trauma recovery
This narrative review explores the role of erythrocytes in trauma, highlighting their immunomodulatory functions and potential to drive path…
Red blood cells do more than carry oxygen; they may actively help manage inflammation and tissue repair after a physical injury.
Allogeneic hematopoietic stem cell transplantation provides salvage for refractory chronic immune thrombocytopenia in a child
Stem Cell Transplant Shows Potential for Refractory Immune Thrombocytopenia
This case report with literature review describes a 6-year-old child with refractory chronic immune thrombocytopenia who achieved complete r…
A stem cell transplant provided a path to remission for a child with a severe form of immune thrombocytopenia.
Vunakizumab may induce severe ulcerative colitis and hepatic enzyme elevation in patients with psoriatic arthritis
Vunakizumab Linked to Severe Ulcerative Colitis in Single Case
This case report and literature review describes a single case of severe ulcerative colitis and hepatic enzyme elevation following vunakizum…
A single case report shows a patient developed severe ulcerative colitis and high liver enzymes after receiving vunakizumab injections.
Digital assessment modalities show feasibility and reliability in Myasthenia Gravis but lack independent validation
Digital tools show promise for tracking Myasthenia Gravis symptoms
This guideline provides a narrative review of digital assessment modalities for Myasthenia Gravis. Most studies demonstrate feasibility, adh…
New digital tools like wearable sensors and smartphone tasks could help track Myasthenia Gravis symptoms more closely during remote care.
DNA vaccines against MCPyV LTAg and STAg show potential for Merkel cell carcinoma immunotherapy
DNA Vaccines Show Promise Against Merkel Cell Carcinoma in Mice
This guideline summarizes preclinical data regarding DNA vaccines for Merkel cell carcinoma. The findings indicate that LTAgvax and STAgvax …
New DNA vaccines may help trigger a stronger immune response and slow tumor growth in models of Merkel cell carcinoma.
Cryopreserved PBMC starting material is a feasible approach for CAR-T cell manufacturing in hematological malignancies
Cryopreserved Cells Show Potential for CAR-T Cell Manufacturing
This systematic review evaluates the impact of cryopreserved versus fresh PBMC starting materials on CAR-T cell manufacturing outcomes. The …
Frozen blood cells may work as a viable starting material for CAR-T cell therapy, showing similar expansion and activity to fresh cells.
CAR-engineered immune cells and Treg-cell therapies show biological plausibility but limited human evidence in IBD
Immune Cell Therapies Show Potential for Inflammatory Bowel Disease
This systematic review of 11 studies evaluates CAR-engineered immune cells and Treg-cell-based therapies for inflammatory bowel disease. Whi…
New immune cell therapies like CAR-T cells show promise for inflammatory bowel disease, though human evidence is currently limited and early…
Therapeutic extracellular vesicles may curb inflammation and restore mitochondrial quality in osteoarthritis
Tiny particles may offer new hope for osteoarthritis treatment
This systematic review examines the role of extracellular vesicles (EVs) in osteoarthritis, identifying both pathological and therapeutic EV…
Small particles called extracellular vesicles could stop the cycle of joint damage and inflammation in people with osteoarthritis.
High Siglec-15 Tumor Expression Tied to Worse Survival
High Levels of Siglec-15 Protein Linked to Shorter Survival in Solid Tumors
Meta-analysis of 4,075 patients shows high tumoral Siglec-15 expression is linked to poorer overall survival (HR 1.53).
Doctors found that high levels of a specific protein called Siglec-15 are linked to worse outcomes for patients with solid tumors.