Natural polyphenol extracts exert multi-target hepatoprotective activities via redox homeostasis and immune responses
Polyphenols Show Promise for Immune Liver Injury
This systematic review synthesizes evidence on the role of natural polyphenol extracts in managing immune-mediated liver injury. The authors…
Natural polyphenols may help protect the liver by calming inflammation and oxidative stress, but human evidence is still lacking.
FDA Approves Adrenalin (epinephrine) for Anaphylaxis and Septic Shock Hypotension
FDA Approves Adrenalin for Severe Allergic Reactions and Septic Shock
The FDA has approved Adrenalin (epinephrine) for emergency treatment of allergic reactions including anaphylaxis and to increase mean arteri…
The FDA approved Adrenalin (epinephrine) for two emergencies: severe allergic reactions, including anaphylaxis, and low blood pressure from …
FDA Approves Orladeyo (berotralstat) for Prophylaxis of Hereditary Angioedema Attacks
FDA Approves Once-Daily Pill to Help Prevent Hereditary Angioedema Attacks
The FDA approved Orladeyo (berotralstat) for prophylaxis to prevent hereditary angioedema attacks in adults and pediatric patients 2 years a…
The FDA approved Orladeyo (berotralstat), a once-daily pill for adults and children 2 and older with hereditary angioedema. It helps prevent…
JAK-STAT pathway activation promotes immunosuppressive microenvironments and inhibits immune cell function in breast cancer
JAK-STAT Pathway Linked to Immune Suppression in Breast Cancer
This systematic review examines the role of the JAK-STAT signaling pathway in the breast cancer immune microenvironment. The authors conclud…
A specific signaling pathway may help create a protective environment for breast cancer cells by weakening the body's natural immune defense…
Various mitigation technologies reduce acrylamide levels in thermally processed foods through distinct physical and chemical mechanisms
New ways to lower acrylamide levels in cooked foods
This narrative review synthesizes the efficacy of technologies like pulsed electric fields, ultrasound, and high-pressure processing in redu…
New processing methods like ultrasound and high pressure may help lower acrylamide levels in foods cooked at high temperatures.
Exercise therapy improves balance and functional mobility in older adults with chronic conditions
Exercise May Improve Balance in Older Adults With Chronic Conditions
This meta-analysis of 857 community-dwelling older adults with chronic conditions found that exercise therapy significantly improved One-Leg…
A new analysis finds exercise may help older adults with chronic conditions stand on one leg longer and move faster, but falls evidence is s…
Single-cell RNA sequencing characterizes immune cell heterogeneity and metabolic reprogramming in gynecological cancers
New technology helps map immune cells in gynecological cancers
This systematic review examines the application of single-cell RNA sequencing (scRNA-seq) in ovarian, endometrial, and cervical cancers. The…
New mapping techniques reveal how immune cells behave and change inside tumors of the ovaries, uterus, and cervix.
PD-1/PD-L1 inhibitors plus chemotherapy improve survival in recurrent or metastatic cervical cancer
PD-1 Inhibitors Combined With Chemotherapy Improve Cervical Cancer Survival
This meta-analysis of randomized controlled trials evaluated PD-1/PD-L1 inhibitors combined with chemotherapy and bevacizumab for recurrent …
Adding PD-1 or PD-L1 inhibitors to chemotherapy may extend survival and delay disease progression for patients with advanced cervical cancer…
H. pylori shows no overall link to pediatric asthma, but subgroup signals diverge
Review of how stomach bacteria might affect childhood asthma and digestive health
This systematic review and meta-analysis examined associations between Helicobacter pylori infection and immune-mediated disorders in childr…
Experts looked at whether a common stomach infection affects kids with asthma or other digestive issues. The results were not clear.
Ulcerative Colitis Trials Shift Toward Biologics and Small Molecules Since 2019
Biologics and Targeted Drugs Show Growth in Ulcerative Colitis Trials
This scoping review maps clinical trials in active ulcerative colitis and finds a rapid increase in trial numbers since 2019, with biologics…
Newer treatments like biologics and small-molecule drugs are becoming more common in clinical trials for active ulcerative colitis.
Expert consensus identifies 60 to 90 incident C3G cases annually in Italy with 94% agreement
Experts Reach Consensus on C3 Glomerulopathy Diagnosis and Treatment
This guideline based on a Delphi study of 17 Italian nephrologists establishes consensus on C3G epidemiology and treatment goals. Experts id…
Experts identify key challenges in managing C3 glomerulopathy, including the need for faster diagnosis and more specific treatment options.
Macrophage-fibroblast interactions drive inflammatory amplification and cartilage-degrading enzyme production in osteoarthritis
Cell interactions drive inflammation and tissue damage in osteoarthritis
This mini review examines macrophage-fibroblast interactions in osteoarthritis. Findings suggest that macrophage signals increase fibroblast…
New research reveals how specific cell interactions drive the inflammation and tissue breakdown seen in osteoarthritis.