Narrative review discusses immune checkpoint inhibitors in lung cancer patients
New Hope for Lung Cancer Patients
This narrative review examines immune checkpoint inhibitors (ICIs), including PD-1/PD-L1 and CTLA-4 inhibitors, for patients with lung cance…
Lung cancer patients now have a fighting chance as new medicines help the body's own immune system attack tumors instead of just killing cel…
Narrative review discusses transcriptomics and algorithms in rheumatoid arthritis care
New AI and Gene Maps May Pinpoint Your Rheumatoid Arthritis Treatment
This narrative review examines the integration of transcriptomics, spatial technologies, and advanced algorithms within rheumatoid arthritis…
This new approach could end the trial-and-error guessing game of finding the right RA medication.
Gut microbial IgA coating levels in infancy differ between urban and agrarian cohorts, linked to allergic outcomes
Babies’ Gut Coating May Prevent Allergies
This cohort study compared gut microbial IgA coating levels in infants from an urbanized and a traditional agrarian community.
A special gut coating in babies may stop allergies before they start, protecting infants from eczema and food reactions.
Systematic review of immunosuppression for SLE-associated intestinal pseudo-obstruction
SLE Can Shut Down the Gut — But It Might Be Reversible
This review synthesized 43 cases of SLE-associated intestinal pseudo-obstruction.
Lupus can paralyze the gut without a blockage, but early treatment with immunosuppressives often reverses this dangerous complication.
Review of intranasal influenza vaccines compared to intramuscular seasonal vaccines
Your Next Flu Vaccine Might Come From Your Nose
This review evaluates intranasal influenza vaccine platforms, including licensed and emerging replicating and non-replicating types, against…
New flu sprays target the virus at your nose and throat, aiming to stop infection before it enters your body for better protection.
Meta-analysis identifies DNA methylation markers linked to asthma exacerbations in diverse pediatric populations
Blood Markers May Predict Severe Asthma Attacks in Kids
This meta-analysis synthesizes data from African American and Latino pediatric populations and ethnically diverse participants to evaluate D…
New research spots chemical changes in blood that signal when asthma might get dangerous.
Combined digital and paper audit feedback did not improve asthma prescribing versus digital-only in primary care
Paper Letters Add Nothing to Digital Asthma Care Plans
This cluster randomized controlled trial in 270 primary care practices in West Yorkshire compared combined digital and paper audit and feedb…
Sending printed reports to doctors does not improve asthma care more than sending emails.
Systematic review on QS-21 production scalability and sustainability strategies
Your Next Vaccine May Depend on a Tree in Chile
This systematic review synthesizes evidence on production and sustainability strategies for Quillaja saponin QS-21.
A key ingredient in top vaccines comes from a single tree species, and researchers are now figuring out how to make enough for the whole wor…
Systematic review proposes S100A8/A9–NETosis feedback loop as core sepsis mechanism
Sepsis May Have a Hidden Engine Driving Death
This systematic review synthesizes evidence on sepsis, proposing the S100A8/A9–NETosis positive feedback loop as a core pathological mechani…
A dangerous cycle between immune cells and blood clots may be the hidden engine driving sepsis death, offering new ways to stop organ failur…
HIV-2 infection shows lower viral loads and slower disease progression than HIV-1 in observational review
Why Some People Control HIV Without Meds: The Surprising Clue Scientists Are Using
This observational review compares HIV-2 and HIV-1 infection.
A different type of HIV shows the body can control the virus long-term, offering new hope for the 40 million people living with HIV worldwid…
Inflammatory cytokines correlate with vestibular-oculomotor dysfunction in Fabry disease patients
Could a blood marker signal eye movement trouble in Fabry disease?
This prospective observational cohort study of 40 Fabry disease patients found significant correlations between specific inflammatory cytoki…
Higher blood inflammation markers in Fabry disease patients are linked to specific eye movement problems like slower eye jumps and less accu…
Current narrative review examines sepsis-associated encephalopathy mechanisms and therapeutic implications
Brain Immune Cells Go Rogue During Sepsis — Scientists May Know How to Reset Them
This narrative review examines the pathophysiology of sepsis-associated encephalopathy, specifically focusing on microglial phenotype change…
During sepsis, the brain's own immune cells turn against it to damage neurons, but new research suggests scientists may know how to reprogra…