Narrative review examines SBRT dose effects on tumor immune microenvironment for ICI resistance
Review explores how radiation dose affects immune response to cancer immunotherapy
A narrative review synthesizes evidence on using stereotactic body radiation therapy to engineer the tumor immune microenvironment and overc…
Moderate radiation doses may unlock better immune responses to cancer treatments, while very high single doses could weaken the body's natur…
Systematic review finds moderate to substantial concordance among fungal sIgE detection kits for asthma
Review finds variation in tests for fungal allergy in asthma patients
A systematic review of 16 human studies evaluating 32 commercial fungal sIgE detection kits found moderate to substantial concordance with t…
Asthma fungal allergy tests often give different results because commercial kits use different methods and cut-off points, making it hard to…
Chemotherapy in HGSOC patients modulates NK cell receptors and ligands, observational study finds
Chemotherapy linked to immune system changes in ovarian cancer patients
An observational cohort study of 107 HGSOC patients and 50 healthy controls found chemotherapy was associated with modulation of NK cell rec…
Chemotherapy in ovarian cancer may restore natural killer cell markers to healthy levels and boost proteins that help immune cells fight tum…
IFN-I signature correlates with alloimmunization transcriptomic programs in SLE patients
Could a common lupus signal reveal who's at risk for transfusion complications?
An observational cohort analysis of 150 SLE patients from three RNA-seq cohorts found a significant positive correlation between Type I inte…
A high Type I interferon signal in lupus patients strongly predicts genetic markers linked to dangerous immune reactions to blood transfusio…
Lysine lactylation links metabolism to neuroinflammation via chromatin and protein modification
Review explores how a metabolic process may influence brain inflammation
A systematic review synthesizes emerging evidence that lysine lactylation (Kla) couples glycolytic state to chromatin remodeling and protein…
A metabolic process adding lactate to proteins may signal how brain cells respond to inflammation and stress in injury or disease.
Systematic review links immune cell metabolic remodeling to outcomes in liver transplant recipients
Could immune cell energy shifts hold the key to better liver transplant survival?
A systematic review synthesizes evidence on immunometabolic remodeling in liver transplant recipients.
Immune cell energy shifts after liver transplants determine rejection, injury, and tolerance, improving long-term survival, a new analysis f…
Phase 1 trial finds inhaled JAK1 inhibitor londamocitinib reduces Feno in mild asthma
Can a new inhaled asthma drug calm lung inflammation? Early trial shows promise
This first-in-human, phase 1 randomized controlled trial in 85 healthy volunteers and 18 participants with mild asthma found inhaled londamo…
A new inhaled asthma drug cut a key lung inflammation marker by half in early human testing, showing promise for calming the quiet battle in…
Single-cell and spatial technologies reveal UC pathogenesis insights but face sample size and phenotype heterogeneity limits
New tech maps ulcerative colitis cells, but small study groups limit what we know for sure yet
This systematic review evaluated single cell RNA sequencing, spatial transcriptomic, and proteomic technologies in adult ulcerative colitis …
New technology maps exactly which cells drive ulcerative colitis inflammation, helping explain why some patients respond to medicine while o…
FOXA transcription factors modulate epithelial integrity and inflammation in allergic asthma models
Review explores how FOXA proteins may influence asthma and allergic airway disease
A systematic review examines the role of FOXA transcription factors in allergic airway disease.
In healthy lungs, FOXA proteins keep airways stable, but allergic reactions shift these levels to worsen inflammation and airway changes.
Oral deucrictibant reduced hereditary angioedema attack rates versus placebo in a phase 2 trial
Can a daily pill prevent painful swelling attacks for people with hereditary angioedema?
A phase 2 randomized trial in 34 adults with hereditary angioedema types 1 or 2 found that daily oral deucrictibant (20 mg or 40 mg) signifi…
A daily pill reduced painful hereditary angioedema attacks by 80% in adults taking it for 12 weeks, offering a new preventive option for thi…
Oral deucrictibant reduces hereditary angioedema attack severity in phase 2 crossover trial
Oral drug reduces hereditary angioedema attack severity in phase 2 trial
In a phase 2 randomized, double-blind, placebo-controlled crossover trial of 62 adults with hereditary angioedema, oral deucrictibant (10 mg…
A new oral drug reduced the severity of hereditary angioedema attacks compared to placebo, offering a convenient treatment option for painfu…
Comparative review of eight national food-based dietary guidelines shows convergence in scientific rigor and communication
How do countries tell people to eat? A look at eight national food guides
A narrative review comparing Food-Based Dietary Guidelines from eight countries found all adopted periodic revisions and strengthened alignm…
Eight countries are updating food guides with simpler visuals and cultural tips, but sustainability advice varies wildly between them.