Tofacitinib used in single case of steroid-refractory multi-organ immune-related adverse events
Single case shows tofacitinib may help with severe immune side effects from cancer immunotherapy
A case report describes a 75-year-old female with colon cancer who developed steroid-refractory immune checkpoint inhibitor-associated myoca…
A single case shows tofacitinib helped a cancer patient recover from severe heart inflammation that steroids could not fix, though infection…
Mobile App Plus Standard Care Shows Mixed Results for Asthma Control in Malaysian Adults
Can a phone app help adults with asthma breathe easier?
A 6-month RCT of 162 adult asthma outpatients in Malaysia compared the CareAide® mobile app plus standard care to standard care alone.
A phone app helped some Malaysian adults with asthma feel more in control of their breathing after six months of use alongside standard care…
Earlier menarche linked to macrosomia risk; dietary patterns may modify association in Chinese cohort
Could a woman's first period timing affect her baby's birth weight?
A prospective cohort study of 2,554 Chinese women found earlier age at menarche (before age 13) was associated with higher odds of macrosomi…
Women whose first period started before age 13 had nearly double the odds of having a larger-than-average baby compared to those who started…
Gut microbiome interventions show conceptual promise for allergic rhinitis but clinical application remains constrained
Can fixing your gut help with seasonal allergies? The science isn't ready yet
A narrative mini-review examining gut microbiome-based interventions for allergic rhinitis found these therapies represent a promising conce…
Gut microbiome therapies for seasonal allergies show promise, but doctors lack standard tests to measure results or confirm long-term safety…
Review explores mitochondrial transfer mechanisms in immune microenvironment remodeling across diseases
Review explores how cells share mitochondria to influence immune responses in disease
A systematic review summarizes emerging evidence on intercellular mitochondrial transfer mechanisms in inflammation, cancer, and autoimmune …
Cells swap energy factories to reshape immune responses in cancer, inflammation, and autoimmune diseases, offering new ways to target these …
Review suggests T cell epitope vaccines may help control dengue infection and modulate ADE risk
Could targeting T cells lead to a safer dengue vaccine?
A systematic review examines research on dengue virus T cell epitope-mediated immunity and antibody-dependent enhancement (ADE).
A new dengue vaccine strategy targeting T cells could help control the virus and reduce the risk of severe disease from antibody-dependent e…
Elevated neutrophil-to-lymphocyte ratio correlates with higher mortality in rheumatoid arthritis
Higher blood cell ratio linked to increased mortality risk in rheumatoid arthritis patients
A meta-analysis of seven observational studies in patients with rheumatoid arthritis found elevated neutrophil-to-lymphocyte ratio (NLR) was…
A high blood cell ratio linked to severe inflammation raises the risk of death by 70% for people with rheumatoid arthritis.
Phase 3 trial compares switch to doravirine/islatravir versus continuing bictegravir/FTC/TAF in HIV-1
Phase 3 trial compares two HIV drug regimens for people already virologically suppressed
A phase 3 randomized controlled trial enrolled 643 virologically suppressed adults with HIV-1 to compare switching to doravirine/islatravir …
People with HIV already on effective treatment can safely switch to a new two-drug pill without losing virus control, according to a complet…
Systematic review finds neoantigen vaccines show recurrence-free survival benefit in adjuvant melanoma
Can a custom vaccine help stop melanoma from coming back?
A systematic review of clinical trial data found that customised neoantigen vaccines, specifically mRNA-4157 from the KEYNOTE-942 trial, dem…
A custom mRNA vaccine linked to longer recurrence-free survival for melanoma patients after surgery, though it works best against 'hot' tumo…
Meta-analysis finds 2.31% EoE incidence with food allergen immunotherapy, none with aeroallergen SLIT
Study finds link between food allergy treatment and rare swallowing condition
A systematic review and meta-analysis of 17 studies in patients receiving allergen immunotherapy found the incidence of confirmed eosinophil…
Food allergy treatment linked to rare swallowing condition in 2.3% of patients receiving food desensitization, while airborne treatments sho…
Remote digital asthma management shows modest quality of life and lung function improvements in adults
Can asthma apps and websites help adults breathe easier?
A meta-analysis of 10 trials in adults with asthma found interactive remote digital management improved quality of life, symptom control, an…
Digital asthma tools show small lung function gains, but quality of life improvements were modest and didn't reach the threshold for patient…
Review explores ferroptosis in ocular microenvironment and potential therapeutic interventions
Could a new type of cell death be harming your eyes?
A systematic review evaluates the role of ferroptosis in ocular neuroinflammation and tissue degeneration.
Scientists are focusing on a destructive process called ferroptosis, where cells die from iron overload, as a potential driver of eye inflam…