Meta-analysis identifies DNA methylation markers linked to asthma exacerbations in diverse pediatric populations
Blood Markers May Predict Severe Asthma Attacks in Kids
This meta-analysis synthesizes data from African American and Latino pediatric populations and ethnically diverse participants to evaluate D…
New research spots chemical changes in blood that signal when asthma might get dangerous.
Combined digital and paper audit feedback did not improve asthma prescribing versus digital-only in primary care
Paper Letters Add Nothing to Digital Asthma Care Plans
This cluster randomized controlled trial in 270 primary care practices in West Yorkshire compared combined digital and paper audit and feedb…
Sending printed reports to doctors does not improve asthma care more than sending emails.
Systematic review on QS-21 production scalability and sustainability strategies
Your Next Vaccine May Depend on a Tree in Chile
This systematic review synthesizes evidence on production and sustainability strategies for Quillaja saponin QS-21.
A key ingredient in top vaccines comes from a single tree species, and researchers are now figuring out how to make enough for the whole wor…
Systematic review proposes S100A8/A9–NETosis feedback loop as core sepsis mechanism
Sepsis May Have a Hidden Engine Driving Death
This systematic review synthesizes evidence on sepsis, proposing the S100A8/A9–NETosis positive feedback loop as a core pathological mechani…
A dangerous cycle between immune cells and blood clots may be the hidden engine driving sepsis death, offering new ways to stop organ failur…
HIV-2 infection shows lower viral loads and slower disease progression than HIV-1 in observational review
Why Some People Control HIV Without Meds: The Surprising Clue Scientists Are Using
This observational review compares HIV-2 and HIV-1 infection.
A different type of HIV shows the body can control the virus long-term, offering new hope for the 40 million people living with HIV worldwid…
Inflammatory cytokines correlate with vestibular-oculomotor dysfunction in Fabry disease patients
Could a blood marker signal eye movement trouble in Fabry disease?
This prospective observational cohort study of 40 Fabry disease patients found significant correlations between specific inflammatory cytoki…
Higher blood inflammation markers in Fabry disease patients are linked to specific eye movement problems like slower eye jumps and less accu…
Current narrative review examines sepsis-associated encephalopathy mechanisms and therapeutic implications
Brain Immune Cells Go Rogue During Sepsis — Scientists May Know How to Reset Them
This narrative review examines the pathophysiology of sepsis-associated encephalopathy, specifically focusing on microglial phenotype change…
During sepsis, the brain's own immune cells turn against it to damage neurons, but new research suggests scientists may know how to reprogra…
Narrative review synthesizes evidence on NAFLD, NASH, and viral hepatitis management without reported trial data
Your Liver Has an Immune Army — and It Can Turn Against You
This narrative review addresses management considerations for nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH),…
Your liver's own immune cells can turn on itself to cause permanent scarring, but scientists are now mapping these cells to stop the damage …
Review evaluates lactate-lactylation signaling hub targeting for dismantling tumor-driven immunosuppression and overcoming therapeutic resistance
Why Some Cancers Shrug Off Immunotherapy — and What May Change That
This review examines the lactate-lactylation signaling hub as a potential metabolic-epigenetic strategy.
Tumors use sugar-burning waste to block immune cells and resist treatment, but new therapies targeting this process could help immunotherapy…
Phase 1b trial of intravenous B001 shows favorable safety in aquaporin-4-positive NMOSD patients
A New MS-Like Disease Drug Passes Its First Human Safety Test
This Phase 1b randomized, double-blind, placebo-controlled trial evaluated intravenous B001 in 22 patients with aquaporin-4 immunoglobulin G…
A new drug for a rare nerve disease that can cause blindness and paralysis passed its first human safety test with no severe side effects se…
Narrative review explores multimodal approaches for autoimmune diseases including rheumatoid arthritis and Crohn's
Scarring From the Inside: How Your Immune System Can Turn Against Your Own Organs
This narrative review examines the integration of immune modulation, epigenetic reprogramming, and mechanobiological interventions for autoi…
Your immune system can cause permanent scarring inside organs like lungs and joints, driving autoimmune diseases such as rheumatoid arthriti…
Case report describes obinutuzumab achieving renal remission in elderly podocytopathy with B-cell disorder
A Cancer Drug Cleared a Man's Failing Kidneys — and Doctors Aren't Sure Why
This single case report details the use of obinutuzumab in a 76-year-old male with podocytopathy and a suspected B-cell lymphoproliferative …
A blood cancer drug put a 76-year-old man's failing kidneys into complete remission within one month, offering hope for elderly patients wit…