STAT1 and IL-7 show diagnostic potential for ovarian carcinoma subtypes in cohort study
Two Tiny Signals Could Help Doctors Tell Apart Two Ovarian Cancers
A cohort study analyzed transcriptome data from 68 patients with high-grade and low-grade serous ovarian carcinoma.
Two tiny gene signals may help doctors distinguish between two ovarian cancer types when biopsy results are unclear, guiding the right treat…
EBV DNA positivity links to MS risk genes in a cross-ancestry study of 617,186 participants
A Common Virus May Hold the Key to MS — Here's Why
This cross-ancestry genome-wide association study analyzed 617,186 individuals to investigate the relationship between Epstein-Barr virus (E…
A virus almost everyone carries may quietly flip immune switches that set off multiple sclerosis by altering how B cells signal to T cells.
Observational study identifies distinct immunophenotypic signatures in ME/CFS and long COVID compared to healthy controls
Two Look-Alike Illnesses May Finally Have Separate Fingerprints
This observational study analyzed peripheral blood mononuclear cells from 207 participants with myalgic encephalomyelitis/chronic fatigue sy…
For the first time, scientists can tell two confusing, often-mixed-up illnesses apart by looking at specific immune cells in the blood.
Review discusses ACSL4 metabolic switch potential in hepatocellular carcinoma therapy strategies
Review suggests metabolic switch concept may guide future liver cancer treatments
This mini-review examines the role of ACSL4 as a metabolic switch rather than a static oncogenic factor in hepatocellular carcinoma.
Viewing a liver cancer protein as a metabolic switch could guide new therapies that boost a specific cell death process to fight tumors.
Review of CAR-T cell therapy for pancreatic ductal adenocarcinoma reports no specific outcomes or safety data
First CAR-T for Pancreatic Cancer Approved
This narrative review addresses the application of CAR-T cell therapy for pancreatic ductal adenocarcinoma.
For the first time, a new drug approved for pancreatic cancer uses immune cells to attack solid tumors instead of just blood cancers.
Meta-analysis links long-term glucocorticoid use and SLE duration to high osteoporosis prevalence in patients
Lupus Patients Face Hidden Bone Loss Risk
This systematic review and meta-analysis evaluated 59 studies involving patients with systemic lupus erythematosus (SLE) to assess bone heal…
Bone loss affects 1 in 6 lupus patients, a hidden risk often overlooked due to the disease and its treatments.
Narrative review examines immune modulation strategies for beta-cell replacement in type 1 diabetes
Can changing the immune system help replace damaged cells in Type 1 diabetes?
This narrative review explores immune modulation strategies for beta-cell replacement, including graft-intrinsic immune engineering, local g…
New strategies aim to stop the immune system from attacking insulin cells, offering a potential path to replace damaged tissue in Type 1 dia…
Narrative review explores immune monitoring for relapse prediction after AML stem cell transplant
Can better immune monitoring help predict relapse in leukemia patients after stem cell transplants?
This narrative review examines immune monitoring methodologies for predicting relapse in acute myeloid leukemia patients after allogeneic he…
New immune monitoring tools could spot leukemia relapse risks earlier than standard tests after stem cell transplants, helping doctors tailo…
Systematic review synthesizes immune and genetic factors in African SARS-CoV-2 populations
Why Africa saw milder COVID-19
This narrative synthesis reviews 40 studies from African settings regarding SARS-CoV-2 infection.
Africa saw milder COVID-19 because unique genes and immune defenses helped people fight the virus without getting severely sick.
Review of ISG15 pathway targeting for inflammatory and cardiovascular diseases
A Tiny Protein That Fuels Your Inflammation
This narrative review examines the potential of targeting the ISG15 pathway to treat inflammatory diseases, including skin, cardiovascular, …
Understanding this protein could lead to better medicines for skin, heart, and brain diseases.
Budesonide-glycopyrronium-formoterol fumarate dihydrate improved lung function and reduced severe exacerbations versus budesonide-formoterol in inadequately controlled asthma
New Asthma Drug Cuts Attacks Without Recent Crisis
This phase 3 randomised, double-blind, double-dummy, parallel-group trial evaluated budesonide-glycopyrronium-formoterol fumarate dihydrate …
A new asthma combo therapy improves breathing and lowers severe flare-up risk for patients who haven't had a recent emergency room visit.
Home-based e-based exercise protocol feasibility study for patients with multiple sclerosis and comorbidities
Working Out From Home Could Slow Multiple Sclerosis Progression
This protocol describes a home-based e-based physical exercise program for patients with multiple sclerosis (pwMS) with and without comorbid…
A new trial tests if twice-weekly online resistance exercise from home can improve walking ability and reduce disease activity in people wit…