Natural and synthetic compounds suppress inflammasome activation in NLRP3-driven pathologies
Your body has a built-in alarm system. It wakes up when you get a sore throat or a fever. But sometimes, this alarm gets stuck in the "on" position. That stuck alarm causes chronic pain and swelling. Scientists are finally learning how to turn it off
This systematic review examined molecular mechanisms involving natural compounds like oridonin and pristimerin, alongside synthetic inhibito…
A hidden protein key inside your cells triggers the stuck alarm that causes chronic pain and swelling, and scientists now know how to stop i…
Peri- and postmenopausal hormonal changes may exacerbate asthma, rhinitis, cough, allergies, hypersensitivity, anaphylaxis, and angioedema
Menopause Changes Allergy Rules for Women
This systematic review examines the association between declining and fluctuating estrogen and progesterone levels and various allergic and …
Menopause can worsen allergies like hay fever and asthma because dropping estrogen levels make your immune system more reactive to triggers.
AQST-109 sublingual film shows faster time-to-peak concentration than epinephrine autoinjectors in healthy adults
The Allergy Shot That Goes Under Your Tongue Instead
A phase 3 RCT in healthy adults compared AQST-109 sublingual film to intramuscular epinephrine.
A dissolving film under the tongue delivers epinephrine faster than an EpiPen, offering a needle-free option for severe allergy emergencies.
Occupational toxic particle exposure linked to increased pulmonary sarcoidosis risk in meta-analysis
The Dusts and Fumes Linked to a Strange Lung Disease
This systematic review and meta-analysis evaluated 13 studies published between 2000 and 2025 to assess occupational exposures as risk facto…
A review of 13 studies found that specific workplace dusts and chemicals are linked to sarcoidosis, a mysterious lung disease that leaves ti…
Systematic review assesses liquid biopsy technologies for early detection of drug resistance and therapeutic response monitoring in people
A Simple Blood Test May Catch When Your Cancer Treatment Stops Working
This systematic review evaluated liquid biopsy technologies, including ctDNA, CTCs, and EVs, for monitoring tumor genomics and customizing t…
A simple blood test can detect when cancer evolves to resist treatment weeks before standard scans show any change.
Strategies to screen and reduce adverse events in patients with asthma using systemic corticosteroids
Asthma Patients Are Still Getting Too Many Steroids — Here Is Why That Matters
This systematic review examined real-world practice strategies aimed at identifying and screening patients at risk of adverse events associa…
Asthma patients face serious, preventable harm from overused systemic steroids, yet safer biologics aren't reaching enough people who need t…
Mini-review examines natural product compounds in rodent depression models
Nature's Keys Unlock Depression's Fire
This mini-review evaluated compounds from natural products in rodent models of depression.
Natural compounds may fight depression by targeting brain inflammation through the P2X7 receptor, offering new hope for treatments beyond tr…
Systematic review examines miRNA-mediated neutrophil regulation for acute lung injury, asthma, fibrosis, and lung cancer
Tiny Molecules in Your Blood May Control Lung Inflammation
This systematic review evaluated miRNA-mediated regulation of neutrophil dynamics as a potential therapeutic strategy for acute lung injury,…
Tiny molecules in your blood act as a switch that controls the immune cells causing lung damage in asthma, fibrosis, and cancer.
Systematic review links gut dysbiosis and AhR/TLR4 pathway alterations to non-IgE-mediated cow's milk allergy in infants
Does gut imbalance drive cow's milk allergy in babies?
This systematic review with integrated multi-omics corroboration analyzed 39 studies involving infants aged 0 to 3 years with physician-conf…
Babies with non-IgE cow's milk allergy show gut imbalances with fewer helpful bacteria and fewer signals that help regulate the immune syste…
Pyroptosis endotypes and malnutrition linked to mortality in older adults with community-acquired pneumonia
High inflammation markers linked to higher death risk in older pneumonia patients
This retrospective cohort study evaluated 282 hospitalized older adults (aged ≥75 years) with community-acquired pneumonia.
Older pneumonia patients with high inflammation markers faced a 57.5% death risk, while those with low levels had only 1.2% mortality within…
In lung cancer patients, immune-checkpoint inhibitors were associated with a 16.4% incidence of thyroid irAEs
Thyroid Trouble Might Mean Better Lung Cancer Response
This retrospective analysis of 420 lung cancer patients treated with immune-checkpoint inhibitors at a single Italian center found that 16.4…
Having a mild thyroid reaction while on cancer drugs could actually mean the medicine is working well inside your body.
NIID patients with kidney injury show higher immune markers compared to those without kidney injury
Kidney Pain in NIID Linked to Immune Fire
This retrospective cohort study analyzed 150 genetically confirmed Neuronal intranuclear inclusion disease (NIID) patients across nine terti…
Doctors can now spot kidney trouble in Neuronal Intranuclear Inclusion Disease (NIID) by looking for a specific type of immune fire rather t…