Review of ISG15 pathway targeting for inflammatory and cardiovascular diseases

This publication is a narrative review focusing on the ISG15 pathway as a therapeutic target for various inflammatory conditions. The scope encompasses skin inflammation, cardiovascular inflammation, and neuroinflammation, though specific study populations, sample sizes, and intervention details are not reported in the source text. The authors synthesize existing literature to explore the biological rationale for this approach without presenting pooled effect sizes or specific trial outcomes.

The main argument presented is that targeting the ISG15 pathway represents a promising new strategy for managing inflammatory diseases. However, the review explicitly acknowledges significant limitations inherent to the current body of research. These gaps include a lack of comprehensive data on adverse events, tolerability, and definitive primary outcomes, which are not reported in the available studies.

Due to these limitations, the review does not establish causal relationships or confirm clinical efficacy. The authors caution that while the potential value is highlighted, the evidence is currently insufficient to support widespread adoption. Practice relevance is framed as an area for future investigation rather than an established standard of care, emphasizing the need for further high-quality research to validate these findings.