Left bundle-branch pacing reduced death or heart failure hospitalization compared with biventricular pacing in heart failure with left bundle-branch block.
Left bundle-branch pacing reduced death or hospitalization compared to biventricular pacing in heart failure patients
This randomized clinical trial enrolled 200 patients at six centers in China with heart failure, left bundle-branch block, and an LVEF of 35…
Left bundle-branch pacing cuts heart failure hospitalizations by 70% compared to standard biventricular pacing in patients with severe heart…
Conduction system pacing showed inferior outcomes compared to biventricular pacing in adults with heart failure and left bundle-branch block.
New Brazil study found conduction system pacing was inferior to biventricular pacing for heart failure patients.
This randomized clinical trial enrolled 173 adults with symptomatic heart failure with reduced ejection fraction and left bundle-branch bloc…
A new Brazil trial found conduction system pacing was worse than standard biventricular pacing for heart failure patients, increasing risks …
Elevated circulating Lp(a) levels associated with increased heart failure incidence in 400,631 participants.
Does high Lp(a) truly raise your risk of heart failure, and what does that mean for you?
This meta-analysis of prospective cohort studies involving 400,631 participants evaluated the association between circulating Lp(a) levels a…
High levels of a specific blood protein called Lp(a) are linked to a 34% higher risk of developing heart failure, with the danger rising sha…
Intravascular imaging and FFR-guided PCI reduce major adverse cardiovascular events versus angiography
Advanced imaging and physiology guidance during heart procedures may lower event risk compared to angiography alone
A network meta-analysis of 43 RCTs involving 39,291 patients undergoing PCI found intravascular imaging (IVUS, OCT/OCTA) and fractional flow…
Advanced imaging and physiology guidance during heart procedures may lower event risk compared to angiography alone
HFpEF probability scores rule out disease but show limitations in AF and obesity phenotypes.
HFpEF probability scores work well for typical cases but struggle with atrial fibrillation and obesity
This systematic review evaluated the performance of HFpEF probability scores (HFA-PEFF and H2FPEF) in patients with heart failure with prese…
Heart failure scores work well for typical cases but lose accuracy in patients with atrial fibrillation or obesity due to altered biological…
In CRT recipients with persistent AF, rhythm control improved LVEF compared to rate control strategies.
Does fixing your heart rhythm actually improve pump function in this specific group?
This randomized trial evaluated rhythm versus rate control strategies in 43 CRT recipients with long-standing persistent AF and low biventri…
Fixing irregular heartbeats boosted heart muscle strength in patients with devices, but daily life and exercise ability improved similarly w…
OCT-guided PCI shows better early stent coverage than angiography in NSTE-ACS imaging study
Does looking deeper inside arteries help them heal faster after stent surgery?
A randomized OCT imaging study of 60 NSTE-ACS patients found OCT-guided PCI resulted in 95.2% covered struts at 3 months versus 92.3% with a…
Waiting six months after stent surgery allowed arteries to heal better than immediate scans, suggesting doctors might wait longer for full r…
Meta-analysis finds IABP may improve 60-day outcomes in advanced heart failure-related cardiogenic shock
Does a balloon pump help the most critical heart failure patients survive longer?
A meta-analysis of 2 RCTs (133 patients with HF-CS) found IABP showed a nonsignificant trend toward better 60-day survival or bridge to hear…
For the sickest heart failure patients, a balloon pump device significantly improved their chances of surviving or reaching a heart transpla…
STEMI guidelines rely heavily on moderate and low-quality evidence, meta-analysis finds
Most heart attack guidelines rely on weak evidence, not strong proof.
A meta-analysis of 26 STEMI guidelines (2,139 recommendations) from 1990-2023 found that 30.1% of recommendations were based on moderate-qua…
Most heart attack treatment rules are based on weak evidence, not strong proof, leaving doctors flying blind on critical care decisions.
CAR T-cell optimization strategies are reviewed for hematologic cancers, solid tumors, and immune-mediated diseases.
Can fixing CAR T-cells in multiple ways finally make them safer and more effective for cancer patients?
This systematic review evaluates CAR T-cell therapy optimization strategies involving genetic, epigenetic, metabolic, and microenvironmental…
Fixing CAR T-cells across genetics, metabolism, and environment offers a safer, more effective path for treating blood cancers, solid tumors…
Federated meta-analysis validates HEART score performance for chest pain risk stratification in EDs
Federated HEART score analysis shows consistent chest pain risk prediction across six emergency departments
A retrospective multicenter observational study of 57,906 ED encounters found that a federated diagnostic meta-analysis approach for the HEA…
A federated analysis of the HEART score predicts chest pain risks just as accurately as centralizing patient data across six emergency depar…
PCSK9 inhibitor initiation associated with lower depression risk versus statins in hyperlipidemia
Could lowering cholesterol with a new drug also protect against new episodes of depression?
A population-based cohort study of 35,610 adults with hyperlipidemia found PCSK9 inhibitor initiation was associated with lower risk of inci…
Starting a new cholesterol drug might lower the risk of developing depression compared to standard statins, based on data from over 35,000 a…