Prednisolone plus standard treatment did not significantly reduce coronary-artery lesions in newly diagnosed Kawasaki disease patients
Adding prednisolone to standard care did not prevent heart damage in Kawasaki disease patients
This multicenter, open-label, randomized, controlled trial evaluated 3208 participants with newly diagnosed Kawasaki disease in China.
Adding prednisolone to standard care did not prevent heart damage in Kawasaki disease patients, as lesion rates remained nearly the same.
Home-based cardiac rehab yields greater mental health and HRQoL gains in heart failure patients with elevated depression
For heart failure patients with depression, home exercise programs improved mental health and daily life
This secondary analysis of individual patient data from the REACH-HF randomized trials (263 patients with HFrEF and HFpEF) tested whether el…
For heart failure patients struggling with depression or anxiety, home exercise programs significantly improved their mental health and dail…
Bipolar linear PFA shows similar safety to RFA for CTI ablation in persistent atrial fibrillation
PFA Ablation Matches Old Method With Less Time
This substudy RCT compared bipolar linear pulsed field ablation (PFA) with irrigated radiofrequency ablation (RFA) in 141 patients with pers…
Doctors can treat a specific heart rhythm problem faster with new technology without making it less safe.
PCI Reduces MACE in Nonfrail Patients With CAD and Severe Aortic Stenosis Undergoing TAVR
PCI reduces heart events in nonfrail patients but increases bleeding risk for frail patients
This randomized controlled trial evaluated percutaneous coronary intervention versus conservative treatment in 407 patients with coronary ar…
Stents cut heart attacks for strong patients with blocked arteries and new valves, but frail patients face higher bleeding risks instead of …
Residual global μQFR assessment associated with 3-year MACE risk in acute coronary syndrome patients
Better Heart Maps Predict Long-Term Survival
This post hoc analysis of a randomized controlled trial evaluated 2,428 acute coronary syndrome patients over 36.0 months.
A new heart map predicts long-term survival just as well as expensive pressure wires, helping doctors spot high-risk patients after stent pr…
Corrective re-analysis suggests Lp(a) reduction accounts for 57-70% of PCSK9 inhibitor benefit in ASCVD
Re-analysis suggests most PCSK9 inhibitor benefit comes from lowering Lp(a)
This Phase 3 corrective re-analysis of cardiovascular outcomes trial data in secondary prevention populations with ASCVD evaluated the role …
Researchers re-analyzed data from Phase 3 trials of alirocumab and evolocumab in patients with atherosclerotic cardiovascular disease.
Systematic review finds low-certainty evidence against endovascular therapy superiority in vertebral artery stenosis
Stents May Not Stop Strokes in Narrowed Neck Arteries
This systematic review evaluated endovascular therapy versus medical treatment alone in adults with symptomatic vertebral artery stenosis.
Stents might not stop strokes in narrowed neck arteries better than medicine alone for people with blocked blood flow to the back of the bra…
POCUS-guided assessments and serial exchange transfusions improved outcomes in a 20-year-old male with sickle cell disease and acute chest syndrome
Bedside Ultrasound Saves Sickle Cell Lives
This single case report describes a 20-year-old male with HbSS, acute chest syndrome, and acute pulmonary hypertension managed in the ICU.
A simple ultrasound at the bedside can tell doctors exactly when a sickle cell patient needs another blood transfusion to save their life.
Review of numerical superiority effects on soccer training load and performance
Soccer Coaches: Stop Overworking Your Best Players
This narrative review examines the impact of manipulating player numbers in small-sided games among soccer players.
Playing with more teammates slows your heart rate and boosts passing, while fewer teammates force tough defense and save energy for smarter …
Systematic review of multimodal machine learning models for heart failure classification and prognosis prediction
Can combining data sources better predict heart failure outcomes than single data types alone?
This systematic review synthesizes evidence from 15 included studies comparing multimodal machine learning models against unimodal approache…
Mixing many data sources to predict heart failure outcomes often beats using just one type, with accuracy scores reaching as high as 98.2 pe…
Meta-analysis of coordinated AED systems for out-of-hospital cardiac arrest in Japan and Poland
Japan's AED System Could Save Lives in Poland
This meta-analysis synthesizes data from Seventeen studies regarding coordinated automated external defibrillator systems for patients with…
A unified national plan for AEDs works far better than scattered devices sitting alone.
Narrative review examines transcriptional regulation in cardiovascular diseases and aging
Could controlling gene activity offer new ways to treat heart disease and slow aging?
This narrative review explores the role of transcriptional regulation within the broader context of cardiovascular diseases and cardiovascul…
Controlling gene activity could offer new ways to treat heart disease and slow aging by targeting the biological networks that maintain hear…