Geranylgeranylacetone mitigates desmin variant-induced atrial cardiomyopathy mechanisms in vitro
A Hidden Heart Flaw May Explain Some Early Atrial Fibrillation
This preclinical in vitro study evaluated HL-1 atrial cardiomyocytes expressing human desmin wild-type or pathogenic variants (p.S13F, p.N34…
A broken heart protein called desmin can silently damage the upper chambers and spark lifelong rhythm problems, while a potential rescue dru…
Endothelial cell isolation feasible in 43% of ANOCA patients in observational study
Chest Pain With Clear Arteries? Scientists Just Cracked A Key Clue
An observational study of 79 ANOCA patients (84% female, mean age 58 years) found that endothelial cell isolation from catheterization mater…
Scientists have found a way to study the real cells lining the hearts of people who suffer mystery chest pain, opening the door to answers t…
Withdrawn laboratory study identifies gene expression changes in valvular heart disease-associated atrial fibrillation
A withdrawn study on heart rhythm disorders found specific gene changes but offers no current treatment
A withdrawn laboratory study performed RNA sequencing on PBMCs from 15 patients with valvular heart disease-associated atrial fibrillation a…
A withdrawn study on heart rhythm disorders found specific gene changes but offers no current treatment.
FFR-guided complete revascularization reduces unplanned revascularization in MI patients with multivessel CAD
Complete Heart Repair May Stop Future Emergencies
A meta-analysis of 3,054 patients with myocardial infarction and multivessel coronary artery disease found that FFR-guided complete revascul…
Fixing all blocked heart arteries during surgery may stop future emergencies and unplanned procedures for patients with heart attacks.
Genetic polymorphisms influence pharmacokinetics and bleeding risk for DOACs in meta-analysis
Your DNA May Explain Why Blood Thinners Work Differently for You
A meta-analysis of 39 studies involving 13,300 patients found that genetic polymorphisms (e.g., CES1, ABCB1) are associated with pharmacokin…
Tiny DNA differences may explain why the same blood thinner protects one person but causes bleeding in another.
Pulsed field ablation shows favorable results for freedom from AF compared to other catheter ablation technologies in patients with atrial fibrillation
New Heart Rhythm Treatment Outshines Older Methods
This network meta-analysis evaluated catheter ablation technologies in patients with atrial fibrillation.
Pulsed field ablation may offer faster, more effective heart rhythm restoration than older methods for adults with atrial fibrillation.
Laparoscopic gastrojejunostomy resolved symptoms in a patient with superior mesenteric artery syndrome and duodenal stricture
Man Vomits After Meals For 30 Years — Then Surgeons Find Two Hidden Problems
This case report and literature review describes a 40-year-old man with superior mesenteric artery syndrome and duodenal bulb–descending ulc…
A simple bypass surgery ended 30 years of daily vomiting for a man whose doctors finally found two hidden blockages in his gut.
Narrative review discusses calcium-modifying balloons for PCI in calcified coronary disease
Review of calcium-modifying balloons for treating calcified coronary artery disease
This narrative review evaluates the role of calcium-modifying dedicated balloons, including scoring, cutting, and ultra-high-pressure device…
Specialized balloons can effectively treat hardened heart arteries, offering versatile options as first-line or complementary tools during p…
Axillary IABP support enables ambulation in most heart failure patients with low complication rates
Heart Pump Patients Can Walk Again Before Transplant
A meta-analysis of four retrospective studies in patients receiving axillary IABP support for heart failure found most patients could ambula…
A new heart pump placement lets dying patients walk while waiting for a transplant, keeping them strong for life-saving surgery.
Narrative review examines peak frequency algorithm versus conventional mapping for cardiac arrhythmias
New Tool Clears Up Confusing Heart Signals
This narrative review evaluates the use of a peak frequency (PF) algorithm utilizing Wavelet transformation (WT) compared to conventional ma…
A new tool helps doctors clearly separate confusing heart signals to treat dangerous rhythms more accurately.
CF-LVADs in end-stage heart failure show functional improvements but high readmission in small cohort
A Tiny Pump Is Helping Failing Hearts Last Longer
A retrospective cohort study of 27 patients with end-stage heart failure on CF-LVADs as destination therapy found significant improvements i…
A tiny chest pump helped 27 patients with severe heart failure live longer and feel better, though some still faced hospital readmissions or…
One-year post-CABG diastolic function worsens despite preserved ejection fraction in ischemic heart disease patients
Heart Surgery Makes Pumping Harder Later
This observational review assessed cardiac mechanics in 96 patients undergoing elective coronary artery bypass grafting (CABG) compared to b…
Even when heart surgery restores blood flow, the heart muscle may struggle to relax and fill properly a year later.