Seladelpar shows improved composite endpoint and ALP reduction in PBC with compensated cirrhosis
New Drug Helps Liver Disease Patients With Cirrhosis
A phase 3 RCT program (RESPONSE and ASSURE studies) in patients with primary biliary cholangitis and compensated cirrhosis found seladelpar …
A new drug lowers liver stress markers in patients with cirrhosis, offering hope where older medicines often failed to stop disease progress…
Quantitative susceptibility mapping shows higher deep gray matter alterations in Wilson's disease compared to healthy controls
New scan findings show brain changes in Wilson's disease patients compared to healthy people
This meta-analysis evaluated quantitative susceptibility mapping (QSM) alterations in deep gray matter among 325 patients with Wilson's dise…
A new scan technique reveals specific brain changes in Wilson's disease patients, showing higher metal buildup in key areas compared to heal…
Systematic review examines immunological analysis of Blau syndrome pathogenesis to define treatment pathways
The Rare Childhood Condition That Rewrites What We Know About Inflammation
This systematic review evaluated immunological analyses of Blau syndrome pathogenesis in patients with this condition.
A rare childhood disease causes inflammation through a completely different pathway than scientists expected, opening new doors for treatmen…
Gastotypes predict Helicobacter pylori infection status in gastric mucosal samples with high accuracy
New Stomach Map Reveals Four Hidden Types
This cohort study analyzed 566 gastric mucosal samples to identify microbial community types associated with Helicobacter pylori infection s…
New stomach map reveals four distinct bacterial neighborhoods, showing stool tests cannot tell the real story happening inside your stomach …
Rituximab exposure is associated with serum sickness in patients with multiple sclerosis, nephrotic syndrome, or immune thrombocytopenia
Can taking Rituximab cause a severe allergic reaction that returns if you take it again?
This retrospective review analyzed 39 published case reports of patients with rituximab-induced serum sickness (RISS).
Taking Rituximab can trigger a delayed allergic reaction that returns in most patients if the drug is given again, so doctors must use extre…
Phase I trial of regorafenib plus ipilimumab and nivolumab shows 27.6% response in MSS colorectal cancer
Who Really Responds to a Stubborn Colon Cancer Combo?
A phase I trial in 29 patients with microsatellite-stable metastatic colorectal cancer tested the combination of regorafenib, ipilimumab, an…
A three-drug combo helped some patients with stubborn colon cancer, and immune markers now predict who will benefit most.
Single-cell sequencing reveals T cell clonal patterns in healthy donors and ulcerative colitis patients
T Cells Move Freely in Colon, Not Just in Blood
This observational study analyzed 333,088 T cells from healthy donors and ulcerative colitis (UC) patients using single-cell T cell receptor…
T cells in the colon travel freely across the gut, not just in the blood, reshaping how we understand immune health in conditions like ulcer…
Meta-analysis finds exercise training reduces intrahepatic lipids and improves metabolic markers in NAFLD
Which Workout Melts Liver Fat Fastest? New Rankings Are In
A systematic review and meta-analysis of 1,880 adults with NAFLD found exercise training significantly reduced intrahepatic lipids (SMD: -0.…
A fresh look at 38 trials shows exercise reliably trims liver fat and improves blood sugar, with HIIT leading the pack.
Hepatitis E vaccine linked to elevated spontaneous abortion risk when given 31-60 days before pregnancy
A Vaccine's Hidden Risk Window for Early Pregnancy Loss
An RCT in women vaccinated during or shortly before pregnancy found an elevated risk of spontaneous abortion (Relative Risk 4.3) in HEV239 r…
A Hepatitis E vaccine given one to two months before pregnancy is linked to a higher risk of miscarriage, forcing doctors to rethink timing …
Blood group B alleles associated with increased MIS-C risk in Italian children cohort study
Why Blood Type B May Raise One Rare COVID Risk in Kids
A cohort study of 18 Italian children with MIS-C or Kawasaki-like disease found blood group B alleles conferred increased risk (OR 2.9).
A small study suggests that blood type and inherited immune differences may help explain which children get the rare post-COVID inflammatory…
Machine learning models show moderate to high accuracy for predicting variceal bleeding in cirrhosis patients
New AI Tool Catches Bleeding Risks Early
A systematic review and meta-analysis of 21 studies involving 7,011 cirrhosis patients found machine learning models achieved pooled c-indic…
An AI tool now spots bleeding risks in liver disease earlier than current methods, helping doctors catch dangerous vein swelling before it t…
SBRT plus PD-1 inhibitor and lenvatinib improved PFS in oligoprogressive HCC patients
Radiation Plus Immune Drugs Stops Liver Cancer Growth
This prospective Phase 2 study evaluated stereotactic body radiation therapy (SBRT) combined with continued first-line PD-1 inhibitor-based …
Combining targeted radiation with ongoing immune therapy can restart cancer control in patients whose disease was slowly spreading again.