Phase 2 trial of JNJ-73763989-based regimen shows no HBsAg seroclearance at primary endpoint in HBeAg-positive CHB
New combo lowers hepatitis B virus levels
A phase 2 trial in 54 treatment-naïve, HBeAg-positive chronic hepatitis B patients tested a regimen of JNJ-73763989 ± bersacapavir with nucl…
A new drug combination successfully lowered virus levels in many patients, though clearing the virus completely happened in only about one o…
Vitamin D supplementation associated with improved metabolic markers in patients with Metabolic-Associated Fatty Liver Disease
A Simple Vitamin May Help Your Body Manage a Fatty Liver
This systematic review and meta-analysis evaluated 21 studies involving patients with Metabolic-Associated Fatty Liver Disease (MAFLD) recei…
Vitamin D supplements improved blood sugar, cholesterol, and liver health in people with fatty liver disease, offering a simple add-on to he…
Wearable monitoring characterizes autonomic dysfunction in hypermobile Ehlers-Danlos syndrome compared to healthy controls
Wearable Watch Could End Years of Waiting for hEDS Diagnosis
This prospective cohort study enrolled 30 individuals with hypermobile Ehlers-Danlos syndrome (hEDS) and 28 healthy controls.
A smartwatch can spot the hidden physical changes of hypermobile Ehlers-Danlos Syndrome (hEDS) much faster than current methods.
Nurse-assisted outpatient follow-up reduces 30-day readmissions but not mortality in decompensated cirrhosis
Nurse Care Cuts Hospital Returns for Liver Patients
A meta-analysis of 668 patients with decompensated liver cirrhosis found nurse-assisted outpatient follow-up significantly reduced 30-day re…
Adding nurses to liver care teams significantly cuts 30-day hospital readmissions and improves outcomes for patients with advanced liver dis…
Laparoscopic hemihepatectomy shows higher costs but better QALYs than open approach in European trial
Laparoscopic surgery costs more upfront but may offer better value for some liver patients
A phase 3 randomized controlled trial of 332 patients undergoing hemihepatectomy at 16 European centers found laparoscopic surgery had highe…
Laparoscopic liver surgery costs more upfront but delivers better long-term value and quality of life for patients.
Network meta-analysis finds pegozafermin, OCA, and resmetirom outperform placebo for MASLD fibrosis improvement
New Liver Treatments Show Real Promise in Reversing Scarring
A systematic review and network meta-analysis of 10,119 adult patients with MASLD found pegozafermin, obeticholic acid (OCA), and resmetirom…
For the first time, doctors have clear evidence that new medications can help reverse the dangerous liver scarring caused by common fatty li…
Cognitive-behavioral sleep intervention with nutritional support improves sleep, survival in rectal cancer surgery patients
A Simple Pre-Surgery Habit Change Boosts Cancer Survival Rates
A single-center RCT of 186 stage I-III rectal cancer patients found that adding cognitive-behavioral sleep intervention with nutritional sup…
Teaching patients how to sleep and eat better before a major cancer surgery doesn’t just help them recover—it may help them live longer.
Diet-induced liver fat reduction associated with fasting metabolite changes but not postprandial responses
Your Liver Fat May Be Changing Your Blood After Meals
An integrated RCT and cohort study in 1986 individuals and 80 intervention participants examined liver fat associations with metabolite prof…
What happens in your blood after a meal could be a clearer sign of liver health than a standard fasting test.
SBCE as initial investigation reduces DBE referrals in suspected small bowel Crohn's disease cohort
Skip the invasive scope with this new rule
This retrospective cohort analysis of 98 patients referred for suspected small bowel Crohn's disease compared SBCE as initial investigation …
A simple pill-sized camera can now rule in or out Crohn's disease for 70% of patients, saving them from a more invasive follow-up test.
Endoscopic findings predict advanced gastric signet ring cell carcinoma in CDH1 carriers
A Safer Path for Families with Hereditary Stomach Cancer?
This retrospective observational study examined 390 CDH1 pathogenic variant carriers from 235 families across twelve academic centers.
For families with a high genetic risk for stomach cancer, new research shows advanced tumors often have visible warning signs during standar…
Efruxifermin shows superior fibrosis regression in compensated MASH cirrhosis compared to placebo in a network meta-analysis
New drug ranking shows one treatment stands out for advanced fatty liver scarring
This network meta-analysis evaluated histological efficacy in patients with biopsy-proven compensated metabolic dysfunction-associated steat…
Efruxifermin is the only drug proven to shrink advanced liver scarring without worsening the disease, ranking first among new treatments for…
Carbapenem-resistant hypervirulent Klebsiella pneumoniae infection is associated with significantly higher mortality compared to carbapenem-susceptible strains in 4240 patients
Resistant superbugs kill more than 12 times as often as susceptible strains in severe infections
This systematic review and meta-analysis evaluated clinical outcomes in 4240 patients with hypervirulent Klebsiella pneumoniae (HvKp) infect…
When bacteria resists last-resort antibiotics, patients with severe infections face a 57% death risk instead of 21%.