FDA Approves Rezdiffra (resmetirom) for Noncirrhotic NASH with Moderate to Advanced Fibrosis
FDA approves new drug Rezdiffra for fatty liver disease with scarring.
The FDA approved Rezdiffra (resmetirom) for adults with noncirrhotic NASH and F2 to F3 fibrosis, to be used with diet and exercise. Approval…
The FDA approved Rezdiffra (resmetirom) for adults with a type of fatty liver disease called NASH that has moderate to advanced scarring. It…
Acidic microenvironments reprogram immune cells via pH sensors, driving tissue injury
Acidic environments in the body change how immune cells work
This systematic review synthesizes evidence that acidic microenvironments influence immune cell metabolism and effector functions through pr…
Your immune system uses special sensors to detect acid levels, which can trigger inflammation and tissue damage during infections or cancer.
Subcutaneous semaglutide more than doubles the likelihood of NASH resolution without fibrosis progression
Semaglutide shows promise for treating fatty liver disease and NASH
This meta-analysis of randomized controlled trials evaluated subcutaneous semaglutide in adults with NAFLD or NASH. The analysis found signi…
A new analysis shows that semaglutide can help resolve liver inflammation and improve metabolic health in people with fatty liver disease.
Intensive CV management reduces cIMT progression in RA patients without hepatic steatosis
Liver health impacts heart risk management in rheumatoid arthritis
This post-hoc analysis of a randomized controlled trial involving 236 patients with rheumatoid arthritis evaluated intensive cardiovascular …
Patients with liver fat and rheumatoid arthritis show worse heart markers, but intensive care only slowed artery thickening for those withou…
New guideline tool curates 51 instruments for theory-driven implementation science assessment
New web tool helps researchers use consistent methods for study data
This guideline introduces the Assess section of the Dissemination and Implementation Models Webtool, which curates 51 instruments linked to …
A new online tool provides a curated list of tools to help scientists and practitioners collect more consistent data when studying how progr…
Probiotics modestly reduce pain intensity and weekly episodes in children with abdominal pain disorders
Probiotics may offer modest relief for children with abdominal pain
This systematic review and meta-analysis of 1899 patients found that probiotic supplementation moderately reduces pain intensity and weekly …
New research suggests that probiotics can help reduce the intensity and frequency of stomach pain in children with certain digestive disorde…
Robotic hepatectomy is safe and offers lower blood loss and shorter hospital stays than open surgery
Robotic surgery shows safety and fewer complications for liver disease
This meta-analysis of 7 studies evaluates the safety and feasibility of robotic hepatectomy for benign liver disease. The analysis found a 1…
Robotic surgery for certain liver conditions may lead to less blood loss and shorter hospital stays compared to traditional open surgery.
Tissue-resident memory T cells drive disease relapse after biologic and JAK inhibitor discontinuation in atopic dermatitis
Tissue Memory Cells Linked to Atopic Dermatitis Relapse
This narrative review examines the role of tissue-resident memory (TRM) cells in the pathogenesis and chronicity of atopic dermatitis. The a…
New research identifies how certain immune cells may cause atopic dermatitis to return after patients stop using common treatments like biol…
CD4+ T cells and Tim-3 regulate immune responses and cytokine-mediated injury in severe pediatric pneumonia
Immune system hurdles shape severity of severe childhood pneumonia
This narrative review examines how CD4+ T cells, Tim-3 (HAVCR2), and cytokines influence the host immune response in severe pneumonia. The a…
New research explores how specific immune cells and proteins may drive the intense inflammation seen in children with severe pneumonia.
Trained immunity drives mucosal inflammation and recurrence in patients with chronic rhinosinusitis
Immune memory may drive recurring chronic rhinosinusitis inflammation
This systematic review explores how trained immunity, involving epigenetic and metabolic reprogramming of innate immune cells, contributes t…
New research suggests that a form of immune memory called trained immunity could be why some people experience repeated sinus infections.
MAGIC algorithm and multi-omics approaches facilitate precision management of gastrointestinal acute graft-versus-host disease
Newer management strategies show promise for gastrointestinal graft-versus-host disease
This systematic review synthesizes current management strategies for gastrointestinal acute graft-versus-host disease following allogeneic h…
Doctors are looking at new ways to manage severe gut complications after stem cell transplants using precision medicine and targeted therapi…
Training programs improve healthcare professional confidence and competence in video and text based consultations
Training programs improve provider confidence in virtual and text consultations
This scoping review of 20 studies examines training and education programs for healthcare professionals conducting virtual consultations. Th…
Specialized training helps healthcare workers feel more confident and capable when treating patients through video or text instead of in per…