Tryptophan metabolism pathways like IDO and TDO2 influence immune cell function in end-stage liver disease
New research explores how liver enzymes impact transplant immunity
This systematic review examines the role of tryptophan metabolism, specifically the kynurenine pathway and AhR signaling, in immune toleranc…
Scientists are looking at how specific pathways in the body might help patients with end-stage liver disease accept transplants.
Physical exercise may attenuate inflammation and alveolar bone loss in patients with periodontitis
Exercise May Help Reduce Inflammation and Bone Loss in Periodontitis
This scoping review of 23 studies examines the impact of physical exercise on inflammation and alveolar bone loss in humans and rodents. The…
New research suggests that regular physical exercise may help reduce inflammation and bone loss for people living with gum disease.
Google NotebookLM achieves 99.77% critical accuracy and 89.3% workflow time reduction in systematic review data extraction
AI tools can speed up research on inflammatory bowel disease
This systematic review evaluates the use of Google NotebookLM for AI-assisted data extraction and consensus statement generation regarding I…
A new study shows that using artificial intelligence to organize complex data can cut the time needed for medical research by nearly 90 perc…
Linaclotide combined with polyethylene glycol significantly improves bowel preparation quality in patients with constipation
Combining two medications improves bowel prep for patients with constipation
This meta-analysis of randomized controlled trials evaluated the impact of linaclotide-PEG versus PEG alone on bowel preparation for patient…
A new combination treatment helps people with constipation get a cleaner colon during preparation for a colonoscopy.
Robustly generalizable gut microbiome signatures are identified in patients with colorectal cancer regardless of age
Gut bacteria patterns show consistent signs of colorectal cancer
This meta-analysis of 27 studies involving 6779 samples identified consistent gut microbiome signatures in patients with colorectal cancer. …
New data shows that specific gut bacteria can signal colorectal cancer regardless of a person's age or the type of testing used.
Antibiotic exposure is associated with an 18.7% higher risk of gastrointestinal cancers
Antibiotic use linked to higher risk of gastrointestinal cancers
This meta-analysis of 12 studies indicates that antibiotic use is associated with a statistically significant increase in the risk of gastro…
New data shows a link between taking antibiotics and an increased risk of developing certain gastrointestinal cancers like colorectal cancer…
Gut microbiome biomarkers show AUROC of 0.89 for differentiating colorectal cancer from controls
Gut Microbiome Biomarkers Show Promise for Detecting Colorectal Cancer
This meta-analysis of 27 studies evaluates the diagnostic performance of gut-based biomarkers in patients with colorectal cancer and adenoma…
Specific bacteria in the gut may help identify colorectal cancer and precancerous growths, though age differences can affect how accurate th…
Microbiota-immune-enteric nervous system interactions provide a framework for understanding functional and slow-transit constipation
New Framework Explores Gut Bacteria Links to Chronic Constipation
This narrative review explores the complex interplay between the microbiome, immune system, and enteric nervous system in patients with func…
A new conceptual model explores how gut bacteria, the immune system, and nerves may interact to cause chronic constipation.
Prevention interventions may reduce e-cigarette ever use while cessation-focused efforts likely reduce current adolescent usage
Interventions May Help Reduce E-Cigarette Use in Young People
This systematic review analyzed 10,510 participants across three studies to evaluate interventions for preventing or ceasing e-cigarette use…
Specific programs may help prevent children from starting e-cigarettes or help teenagers who already use them to quit.
Splenic stiffness measurement shows high sensitivity for varices in children with non-cirrhotic portal hypertension
Measuring Splenic Stiffness Helps Identify Dangerous Vein Enlargement in Children
This systematic review and diagnostic test accuracy meta-analysis of 1027 children found that splenic stiffness measurement (SSM) has high s…
New research shows that measuring spleen stiffness can help doctors find dangerous vein growth in children with liver issues.
Upadacitinib 15 mg daily improves pruritus and skin sclerosis in a case of refractory lichen sclerosus
JAK Inhibitor Upadacitinib Shows Promise for Lichen Sclerosus
This case report and brief literature review describes the use of upadacitinib 15 mg daily for a patient with refractory generalized lichen …
A single case report finds upadacitinib may help treat stubborn lichen sclerosus, with no side effects seen over 10 months.
Metabolic and bariatric surgery achieves 70% steatohepatitis remission in patients with MAFLD
Bariatric surgery shows significant improvements for liver disease and diabetes
This meta-analysis of 71,904 patients with biopsy or elastography-confirmed MAFLD found that metabolic and bariatric surgery leads to signif…
Metabolic surgery can help patients with fatty liver disease achieve remission of both liver inflammation and type 2 diabetes.