Systematic review and meta-analysis evaluates ML and DL models for diagnosing MASH and fibrosis
AI models help doctors spot liver disease with high accuracy
This systematic review and meta-analysis of 106 studies assessed machine learning (ML) and deep learning (DL) models for diagnosing metaboli…
New computer tools can diagnose fatty liver disease and scarring with impressive accuracy. This review analyzed data from many studies to se…
Systematic review shows high rates of fibrosis and cirrhosis in children with Pi*ZZ alpha-1 antitrypsin deficiency
1 in 4 children with A1AT deficiency develop cirrhosis
This systematic review and meta-analysis examined children with confirmed Pi*ZZ alpha-1 antitrypsin deficiency to assess liver outcomes.
New analysis finds 41% of children with A1AT deficiency have liver fibrosis and 17% have cirrhosis.
PPAR Agonists Reduce Pruritus in PBC: Meta-Analysis of 660 Patients
New drugs ease itch for patients whose current treatment fails
This systematic review and meta-analysis of 660 patients with primary biliary cholangitis and inadequate response to UDCA found that PPAR ag…
A review of six hundred sixty patients found new medicines significantly reduced itch scores in people with primary biliary cholangitis who …
Meta-analysis finds Virtual Scale Endoscopy improves colorectal polyp measurement accuracy
Virtual Scale Endoscopy cuts errors in colorectal polyp measurements
This meta-analysis of 6 clinical and 5 preclinical studies (1581 polyps) found that Virtual Scale Endoscopy (VSE) significantly improved mea…
A new analysis shows Virtual Scale Endoscopy improves accuracy and reduces mistakes when measuring colorectal polyps compared to standard vi…
Systematic review finds weak link between atypical antipsychotics and MASLD in youth
Atypical antipsychotics show a small link to liver disease in young patients
This systematic review and meta-analysis of 3 studies examined the association between atypical antipsychotics and metabolic dysfunction-ass…
A review of three studies found a small link between atypical antipsychotics and liver disease in children, but the evidence is limited.
Narrative review of traditional Chinese medicine for pancreatitis management
Traditional Chinese Medicine May Help Treat Pancreatitis
This narrative review examines the use of traditional Chinese medicine in patients with pancreatitis.
New research suggests Traditional Chinese Medicine could help treat pancreatitis by fixing gut issues and calming inflammation.
Narrative review discusses NF-kB inhibition for inflammatory bowel diseases and related conditions
Blocking NF-κB May Ease Gut Inflammation in IBD
This narrative review explores the role of NF-kB pathway inhibition in treating inflammatory conditions.
A review finds that blocking a key inflammatory pathway could help treat Crohn's, colitis, and celiac disease.
Systematic review and meta-analysis of colorectal cancer screening prevalence in survivors versus general population
Cancer survivors are more likely to get colorectal cancer screening than the general public
This systematic review and meta-analysis examined colorectal cancer screening prevalence across 59 studies involving cancer survivors and th…
A large review of 59 studies found cancer survivors are more likely to get colorectal cancer screening than those without cancer history.
Meta-analysis finds blood biomarkers predict outcomes in anal cancer but need validation
Low blood counts and high inflammation may signal worse survival for anal cancer patients
This systematic review and meta-analysis of 3589 patients with anal squamous cell carcinoma found that elevated neutrophil-to-lymphocyte rat…
For patients with anal cancer, low hemoglobin and high inflammation markers linked to poorer survival in this analysis of nearly 3,600 peopl…
Early magnesium sulphate catharsis reduces severe acute pancreatitis and mortality in high-risk patients
Early Magnesium Sulfate Treatment May Stop Pancreatitis From Turning Deadly
This clinical retrospective cohort study evaluated 850 patients with acute pancreatitis at high risk of systemic complications. Early magnes…
Early magnesium sulfate treatment may prevent severe pancreatitis and save lives, a large new study suggests.
Sequential SBRT, pembrolizumab, and resection in oligometastatic colorectal cancer shows 60% 1-year RFS
Phase Ib trial shows promising signs for colorectal cancer treatment
This Phase Ib clinical trial evaluated sequential stereotactic body radiotherapy, pembrolizumab, and resection in 15 patients with oligometa…
A Phase Ib trial found that a specific combination therapy helped 60% of patients stay free from cancer recurrence for one year.
Single 6 mg erdafitinib dose shows similar pharmacokinetics in mild or moderate hepatic impairment versus healthy controls
Single dose of erdafitinib showed no dose changes needed for mild or moderate liver issues
This Phase 1 open-label single-dose study evaluated pharmacokinetics of erdafitinib in 26 participants with hepatic impairment versus health…
A single dose of erdafitinib worked well in people with mild or moderate liver problems, showing no need for dose adjustments.