Review explores chronic enterocolitis in rhesus macaques as potential model for post-infectious IBS
Review explores monkey intestinal disease as possible model for human IBS
A systematic review examined chronic enterocolitis (CE) in colony-housed rhesus macaques, which leads to chronic diarrhea and severe weight …
A scientific review examined a chronic intestinal disease in rhesus macaques that causes severe diarrhea and weight loss.
Anti-EGFR rechallenge improves response and PFS but not OS in ctDNA wild-type chemorefractory mCRC
Anti-EGFR rechallenge shows benefit for some advanced colorectal cancer patients
A meta-analysis of three phase II randomized trials (n=320) in pretreated ctDNA RAS/BRAF wild-type mCRC found anti-EGFR rechallenge signific…
Giving anti-EGFR drugs again helps some advanced colorectal cancer patients shrink tumors and delay growth, though it does not extend overal…
Post hoc analysis links TMB ≥9 or BRAF-V600E to longer PFS with chemo-nivolumab in MSS/pMMR mCRC
Could two simple blood tests help predict which colon cancer patients benefit from immunotherapy?
A post hoc analysis of the METIMMOX RCT in patients with metastatic MSS/pMMR colorectal cancer found that in the experimental arm (alternati…
Two simple blood tests and tumor markers can predict which colon cancer patients live longer on immunotherapy combined with chemotherapy.
Meta-analysis links ultra-processed food consumption to increased MASLD risk in 1.2 million participants
Do ultra-processed foods raise your risk of fatty liver disease?
A meta-analysis of 7 prospective cohort studies with 1,272,317 participants found higher ultra-processed food consumption was associated wit…
Eating more ultra-processed foods like sugary drinks and ready meals raises your long-term risk of developing fatty liver disease, a conditi…
TCM formulas and acupuncture show potential for radiation enteropathy in limited evidence
Can Traditional Chinese Medicine help with radiation damage to the gut?
A systematic review found Traditional Chinese Medicine botanical formulas and acupuncture may improve symptoms and reduce inflammatory marke…
Traditional Chinese Medicine formulas and acupuncture may ease gut damage from radiation therapy, with studies showing symptom relief and re…
Platinum-based intraperitoneal chemotherapy improves disease-free survival after curative CRC resection
Study reviews chemotherapy method for colorectal cancer after surgery
A meta-analysis of 1,264 adults receiving curative colorectal cancer resection found platinum-based prophylactic intraperitoneal chemotherap…
Giving chemotherapy directly into the abdomen after colorectal cancer surgery helped patients stay cancer-free longer without adding serious…
Over 100 agents in development for moderate to severe ulcerative colitis, with early remission data for one class
Many new ulcerative colitis drugs are in development, with early trial results for one type
A review describes a pipeline of over 100 investigational agents for moderate to severe ulcerative colitis.
New ulcerative colitis drugs show over 25% remission in early trials, offering hope for the 20% of patients hospitalized within five years o…
Case report describes ischemic proctitis from rectal arteriovenous fistula requiring multiple interventions
When rectal bleeding won't stop, could a hidden blood vessel connection be the cause?
A case report and literature review describes a 61-year-old man with ischemic proctitis caused by a superior rectal arteriovenous fistula.
A rare hidden blood vessel connection caused severe rectal bleeding and scarring in a 61-year-old man, eventually requiring surgical removal…
Perspective reviews emerging antifibrotic therapies for metabolic dysfunction-associated steatohepatitis
Could new drugs finally treat the liver scarring of MASH?
A perspective article reviews emerging antifibrotic therapies for metabolic dysfunction-associated steatohepatitis (MASH), including metabol…
New metabolic drugs and direct liver therapies offer fresh hope for reversing the scarring that leads to dangerous cirrhosis in MASH patient…
Biliary complications in pediatric liver transplant recipients with over 20 years of follow-up
How do doctors manage liver transplant complications decades later in children?
A single-center descriptive analysis of 40 pediatric liver transplant recipients with >20 years follow-up found 13 patients developed biliar…
For some children with liver transplants, late bile duct issues may be managed with close monitoring instead of immediate surgery.
Meta-analysis links maternal health, IBD history, and familial factors to increased IBD risk
Study finds link between pregnancy health, family history, and inflammatory bowel disease risk
A systematic review and meta-analysis of 15 observational studies including 6,507 IBD patients found associations between parental/perinatal…
Mothers with poor pregnancy health or IBD raise their children's risk of inflammatory bowel disease, while any family history also increases…
Meta-analysis finds predictive models for post-ERCP pancreatitis show moderate accuracy
Review finds predictive models for pancreatitis after ERCP show moderate accuracy
A systematic review and meta-analysis of 23 studies evaluated predictive models for post-ERCP pancreatitis in patients undergoing the proced…
Computer models predicting pancreatitis risk after ERCP procedures show moderate accuracy but need more testing before doctors can use them …