Meta-analysis finds R1 vascular margin acceptable for HCC but not CLM in minimally invasive liver surgery
Tumor margin choice matters differently for liver cancer types
This meta-analysis of 839 patients undergoing minimally invasive liver surgery found that R1 vascular margin (R1v) hepatectomy yields local …
For liver cancer, leaving a narrow margin is safe. For colorectal metastases, it raises recurrence risk.
Systematic review and meta-analysis of biopsy-guided versus clinically guided withdrawal in autoimmune hepatitis
Biopsy-guided withdrawal shows no benefit over clinical guidance for autoimmune hepatitis
This systematic review and meta-analysis evaluated relapse rates after treatment withdrawal in patients with autoimmune hepatitis.
A meta-analysis of 518 patients found that biopsy-guided withdrawal did not lower relapse rates compared to clinically guided withdrawal in …
Tislelizumab plus chemotherapy and radiotherapy yields 89.1% 3-year disease-free survival in pMMR/MSS locally advanced rectal cancer
Early trial shows high survival rates for rectal cancer patients treated with tislelizumab
This Phase 2 clinical trial evaluated neoadjuvant tislelizumab, chemotherapy, and long-course radiotherapy in 50 patients with pMMR/MSS loca…
A Phase 2 trial found that adding tislelizumab to standard care helped 89% of patients stay free of cancer for three years. This approach wo…
Chiglitazar reduces liver fat in MASLD patients with hypertriglyceridemia and insulin resistance
Two doses of chiglitazar cut liver fat far more than a placebo in 18 weeks
In a phase II randomized, double-blind, placebo-controlled trial, 104 patients with MASLD, hypertriglyceridemia, and insulin resistance rece…
Patients with fatty liver disease and high triglycerides saw liver fat drop significantly with chiglitazar compared to placebo after 18 week…
AI-Assisted Colonoscopy Improves Right-Sided Adenoma Detection in Gastroenterology Fellows
AI helps trainee doctors find more polyps in colonoscopies
This pragmatic randomized controlled trial assigned 16 gastroenterology fellows to AI-enhanced or conventional colonoscopy for 1045 procedur…
AI-assisted colonoscopy helped gastroenterology fellows detect more polyps on the right side of the colon, a hard-to-see area.
Narrative review explores ferroptosis-immune crosstalk in CNS diseases as therapeutic target
New hope for brain diseases by targeting a deadly cell death cycle
This narrative review synthesizes evidence on the interplay between ferroptosis and immune responses in CNS disorders including Alzheimer's,…
Scientists found a way to stop a deadly cell death cycle that makes brain diseases worse, offering new hope for patients with Alzheimer's an…
SABR in oligometastatic cancer showed median overall survival of 64.6 months in a single-arm phase 2 study
SABR offers five-year survival hope for patients with limited cancer spread
This single-arm phase 2 trial evaluated stereotactic ablative radiotherapy (SABR) in 380 patients with oligometastatic cancer across six Can…
Patients with few cancer spots lived longer with SABR treatment. Five-year survival reached 58.6 percent in this Canadian study.
Preoperative symbiotic supplementation alters gut microbiota in colorectal cancer patients
Small trial shows symbiotic changes gut bacteria in colorectal cancer patients
This randomized clinical trial in 46 adults undergoing colorectal cancer surgery found that preoperative symbiotic supplementation increased…
A small Brazilian trial found that taking a symbiotic before surgery changed gut bacteria and fatty acid levels in colorectal cancer patient…
SABR shows worse survival in ultracentral pulmonary oligometastases compared to nonultracentral tumors
Tumor location matters: ultracentral spots linked to worse survival in lung metastasis patients
This secondary analysis of the SABR-5 Phase 2 trial evaluated progression-free and overall survival in 41 patients with ultracentral pulmona…
Tumor location matters. Patients with ultracentral lung metastases had shorter survival times than those with nonultracentral spots after ra…
Patient Buddy App reduced avoidable readmissions in cirrhosis inpatients compared to standard of care
App helps cirrhosis patients avoid hospital readmission
This randomized clinical trial enrolled 464 subjects (232 dyads) with cirrhosis in a multicenter setting.
A smartphone app cut avoidable hospital readmissions in half for cirrhosis patients, a new trial shows.
HEV 239 vaccine induces durable humoral and cellular immunity in Bangladeshi women
Hepatitis E vaccine shows durable immunity in women
This longitudinal cohort study in 1480 women aged 16-39 years in Bangladesh found that HEV 239 (Hecolin) vaccination led to significantly hi…
A hepatitis E vaccine kept women protected for up to 3 years, with stronger immune memory than a comparison group.
Five ACLF diagnostic models and prognostic scores identified markedly different proportions of patients at risk of 28-day mortality in a cohort study
Two new models find the sickest liver patients faster than old tools
This cohort study evaluated five acute-on-chronic liver failure (ACLF) diagnostic models and prognostic scores in 3,370 patients from the CO…
Two new scoring systems find the most dangerous liver failure patients better than older tools, potentially saving lives by catching risk ea…