In Silico Modeling Predicts Fezolinetant Hepatotoxicity Risk in MAFLD Population
Could a menopause drug harm the liver? A computer model offers clues
Quantitative systems toxicology modeling simulated fezolinetant hepatotoxicity in virtual populations.
A computer model predicts a menopause drug might cause rare liver injury in people with fatty liver disease, but higher doses could be safer…
Prehabilitation improves functional capacity and reduces severe complications in elective colorectal cancer surgery
Can a few weeks of exercise before colon cancer surgery help you recover better?
A meta-analysis of 976 patients undergoing elective colorectal cancer resection found preoperative prehabilitation significantly improved po…
Pre-surgery exercise before colon cancer operations helps patients walk farther and lowers their risk of severe complications after the proc…
New-onset diabetes in adults over 50 associated with higher pancreatic cancer risk within 3 years
Could new diabetes after age 50 signal hidden pancreatic cancer?
A systematic review found individuals around 50 years and over with new-onset diabetes have a higher risk for pancreatic ductal adenocarcino…
New diabetes after age 50 might signal hidden pancreatic cancer, as patients face a higher risk of diagnosis within three years compared to …
Meta-analysis finds 3.2% prevalence of germline MMR mutations in patients with upper tract urothelial carcinoma
Study finds 3.2% of upper tract urothelial cancer patients have inherited DNA repair mutations
A systematic review and meta-analysis of 14 studies including 2378 patients with upper tract urothelial carcinoma (UTUC) found a pooled prev…
About 3% of upper tract urothelial cancer patients carry inherited DNA repair mutations that link their cancer to Lynch syndrome and affect …
Pilot trial finds no between-group muscle mass benefit from HMB supplement in cirrhosis sarcopenia
Small pilot study tests nutritional supplement for muscle loss in liver cirrhosis
A pilot randomized controlled trial of 21 patients with stable decompensated cirrhosis and sarcopenia found no significant between-group dif…
A nutritional supplement with HMB improved leg strength and body composition in cirrhosis patients, though it did not increase overall muscl…
Nurse-led music intervention shows preliminary benefit for cognitive impairment in colorectal cancer patients
Can listening to your favorite music help clear cancer treatment brain fog?
A pilot RCT of 70 colorectal cancer patients with cognitive impairment found a 9-week nurse-led individualized music-listening intervention …
Listening to favorite music helped colorectal cancer patients feel less brain fog, depression, and fatigue while sleeping better during trea…
PFAS exposure linked to sex-specific steroid hormone disruption in MASLD patients
Could common chemicals in our environment worsen fatty liver disease differently in men and women?
An observational study of 104 patients with biopsy-characterized MASLD found PFAS exposure was associated with sex-specific disruption of st…
Common 'forever chemicals' linked to fatty liver disease affect men and women differently by first disrupting steroid hormones.
Meta-analysis finds 4% HBV transmission risk in kidney transplants from active HBV donors
Kidney transplants from donors with active hepatitis B show low transmission risk in review
A systematic review and meta-analysis of 20 cohorts (600 HBsAg-negative recipients) found a pooled HBV transmission rate of 4.0% (95% CI, 1.…
Kidney transplants from donors with active hepatitis B carry a low transmission risk of 4% when recipients take preventive antiviral drugs, …
Endoscopic score predicts recurrence after foam sclerotherapy for grade I hemorrhoids
Can a simple score predict if hemorrhoids will return after treatment?
An observational cohort study of 483 patients with grade I internal hemorrhoids found cumulative recurrence rates of 20.0% at 36 months afte…
A new score using hemorrhoid size, count, color, and sex predicts if foam treatment will fail within three years.
Laboratory study finds gut microbiota profiling feasible using leftover FIT samples
Could leftover colon cancer screening samples unlock secrets of our gut health?
A laboratory method validation study using 16 healthy volunteer stool samples and 100 surplus qFIT samples from symptomatic patients found b…
Leftover colon cancer screening samples stay stable for two weeks, offering a low-cost way to study gut bacteria without needing new tests.
Continuous terlipressin infusion reduces treatment failure and rebleeding in acute variceal bleeding
Could a different way of giving a bleeding drug save more lives?
A meta-analysis of 6 RCTs (n=494) in cirrhosis patients found continuous terlipressin infusion reduced treatment failure (RR 0.32) and reble…
A slow drip of the bleeding drug terlipressin works better than a quick shot, causing fewer side effects and less rebleeding for patients wi…
Feedback message increased CRC screening participation in non-respondents, while offering sigmoidoscopy decreased it
Simple feedback message boosts colorectal cancer screening rates among previous non-attenders
A randomized trial of 20,225 previous non-respondents to CRC screening in Florence tested behavioral messages and alternative test offers.
Adding a simple feedback message to screening invitations increased colorectal cancer screening rates among people who previously skipped th…