GWAS meta-analysis finds female-specific adiposity genetics linked to endometrial cancer risk
Why does body fat affect women's cancer risk differently than men's?
A genome-wide association study meta-analysis of genetic data from 2 million people identified a fourfold larger female-specific genetic com…
A massive genetic study of 2 million people reveals that the link between body fat and endometrial cancer is uniquely female.
Review examines reference gene selection methods for qRT-PCR normalization in cancer research
Review examines gene analysis methods for cancer research and precision medicine
A systematic review describes the progression of traditional and advanced reference gene selection methods for qRT-PCR normalization and the…
Accurate cancer research depends on picking the right reference genes, and new tools now help scientists choose them for better precision me…
Genetic factor in BCAA metabolism linked to type 2 diabetes and coronary artery disease risk
Genetic study finds link between amino acid metabolism and diabetes, heart disease
Genomic structural equation modeling in European and East Asian populations (n=42,826) identified a genetic factor influencing branched-chai…
A new genetic study links how your body processes protein building blocks to higher risks of type 2 diabetes and heart disease beyond weight…
Genetic prevalence estimates for 22 autosomal recessive conditions show wide carrier frequency range
How common are rare genetic conditions? New tool gives clearer estimates
A population data analysis using the Genome Aggregation Database (gnomAD) estimated conservative carrier frequencies for 22 autosomal recess…
A new tool shows carrier chances for rare genetic conditions range from 1 in 164 to 1 in nearly 12,000 people, but these numbers shift as ge…
Early age onset predicts MACE in pediatric cardiomyopathy patients with TTN variants
Study finds early age of onset predicts heart events in children with TTN gene cardiomyopathy
A retrospective observational cohort study of 53 pediatric patients with cardiomyopathy and TTN variants found early age-onset disease predi…
Children with TTN gene heart disease who develop symptoms before age six face higher risks of major heart events like failure or severe rhyt…
Combined tumor markers and CT imaging show high sensitivity for solitary pulmonary nodule malignancy
Study finds combining blood tests and CT scans may help assess lung nodule cancer risk
A retrospective cohort study of 110 patients with solitary pulmonary nodules found that combining serum tumor markers (CEA, NSE, CA-125, CYF…
Combining blood tests and CT scans correctly identified 96.9% of cancerous lung nodules, outperforming either test alone in spotting maligna…
Prime editing therapy shows early neutrophil activity in two patients with p47-deficient CGD
Early trial shows gene editing therapy may restore immune function in two patients with rare disease
A Phase 1 trial in two participants with p47-deficient chronic granulomatous disease (CGD) found that autologous CD34+ cell therapy using pr…
Two patients with a rare immune disorder regained the ability to fight infections after receiving a new gene editing therapy that fixed thei…
Extended goal-directed fluid therapy shows no benefit for complications after esophagectomy in single-center trial
Does personalized fluid therapy after esophageal cancer surgery reduce complications?
A single-center, single-blind RCT of 100 patients undergoing esophagectomy found that extended, individualized goal-directed fluid therapy d…
Personalized fluid therapy after esophageal cancer surgery did not reduce complications, despite higher fluid intake and medication use in p…
Meta-analysis identifies two genomic loci associated with antidepressant non-response in 135,471 individuals
Why do antidepressants fail for some people? New genetic clues emerge
A genome-wide association meta-analysis of 135,471 individuals prescribed antidepressants identified two novel genomic loci associated with …
Millions struggle to find working antidepressants, but new genetic data reveals why some fail and suggests other drug options for treatment …