EBOV-specific gene signature identified in nonhuman primates and human cohorts with Ebola infection
New gene signature can spot Ebola infection in blood samples
This observational cohort study analyzed RNA-Seq data from nonhuman primates and human cohorts with Ebola virus infection and comparator inf…
Researchers found a 50-gene signature that reliably separates Ebola from other infections in blood tests, pointing to a future diagnostic to…
GSTM1 and GSTT1 null genotype frequencies in 300 healthy individuals from urban Venezuela
Why Your Genes Vary by Region
This cross-sectional descriptive study assessed GSTM1 and GSTT1 null polymorphism frequencies in 300 healthy unrelated individuals in an urb…
Imagine you are at a party. Everyone is there to celebrate, but not everyone has the same background.
Demographic factors influence side preference and completeness in nonsyndromic orofacial clefts across multiethnic cohorts
Left Side Clefts Are Often More Severe
This cohort study analyzed 3,561 individuals with nonsyndromic cleft lip with or without cleft palate from North and South America, Asia, an…
Knowing which side of a cleft is usually worse helps doctors plan better care for every child.
Rare CNV dosage associated with Alzheimer's disease risk in exome case-control study
Rare DNA Errors Found Linked to Higher Alzheimer's Risk
This case-control study analyzed exome data from individuals with Alzheimer's disease and controls.
Scientists found specific DNA changes that may make some people more likely to develop Alzheimer's.
RADAR pipeline identifies 20 high-confidence retired antigen candidates from 4,664 initial candidates
Computers Find Safe Targets for New Cancer Vaccines
This Phase 1 computational pipeline development study utilized an in silico analysis of 4,664 initial candidates derived from GTEx.
Imagine a protein that your body ignores when you are healthy but attacks when cells turn cancerous.
UK Biobank observational review links gene-diet interactions to gout risk
Your genes and diet may team up to trigger gout
This observational study from the UK Biobank synthesizes evidence on dietary exposures and gene-diet interactions for cardiometabolic outcom…
A huge UK Biobank study found 20 specific gene-diet interactions linked to health outcomes, including gout. Your genes might influence how f…
Observational transcriptomic analysis identifies genes associated with knee osteoarthritis severity in older adults
Knee Pain Could Start in Your Thigh Muscles, Study Says
This observational study analyzed vastus lateralis muscle RNA from 523 older adults with knee radiographs.
Scientists found specific genes in thigh muscles linked to knee arthritis severity.
Unsupervised clustering of glioma RNAseq data shows diagnostic and prognostic potential
AI-powered analysis reveals hidden brain tumor subtypes with survival links
This unsupervised clustering analysis of public TCGA glioma RNAseq data (n=692) found high diagnostic concordance and prognostic separation.
A new AI method sorted brain tumors into groups that matched clinical diagnoses 91% of the time and uncovered subtypes tied to survival.
Observational analysis links fish oil supplements to genetic variants affecting fatty acid traits in UK Biobank
Fish Oil Supplements Work Differently Depending on Your Genes, Study Finds
This observational analysis of a UK Biobank subset involving 200,478 participants examined associations between fish oil supplements (FOS) a…
Your genes may explain why fish oil supplements help some people lower heart disease risk but do almost nothing for others.
Menopausal transition and testosterone linked to X chromosome inactivation skew in females
Low Testosterone May Affect How Your X Chromosomes Work
This observational cohort study of 1,395 females from the TwinsUK cohort found that early menopause and surgical menopause were associated w…
This study links low testosterone and surgical menopause to a hidden genetic imbalance that may affect women’s long-term health.
Meta-analysis identifies germline susceptibility loci for rare cancers including MDS and GIST
Genes linked to rare cancers found in large study of over 480,000 people
This meta-analysis of observational cohorts from over 480,000 individuals identified novel germline susceptibility loci for rare cancers.
A huge study of over 480,000 people found new genes that raise the risk of several rare cancers, offering clues for families and doctors.
Observational study abstract reports AI RNA sequencing diagnostic accuracy in multiple sclerosis and neuromyelitis optica
Artificial Intelligence identifies early Multiple Sclerosis and separates it from others
This abstract describes an observational diagnostic accuracy study involving 997 participants.
Artificial Intelligence analyzes blood cells to tell early Multiple Sclerosis apart from healthy people and similar conditions like Neuromye…