AlphaFold3 and qCLASH provide higher structural plausibility for miRNA-mRNA interactions than bioinformatic prediction alone
New Tools Help Map How Molecules Interact in Cells
This methodological guideline evaluates three methods for miRNA-mRNA interaction mapping: bioinformatic prediction, qCLASH, and AlphaFold3. …
New research compares three different methods to map how small molecules interact with genes, showing that combining tools provides the most…
GERD shows strong genetic overlap with internalizing psychiatric disorders like MDD and PTSD
Acid reflux and mental health share a common genetic link
This meta-analysis explores the genetic architecture of gastroesophageal reflux disease (GERD) and its relationship to psychiatric condition…
New research shows that acid reflux and mental health conditions like depression and PTSD share the same genetic roots.
Unshelled Sunflower Seeds Linked to Tooth Surface Loss in Scoping Review
Eating unshelled sunflower seeds may cause wear on front teeth
This scoping review examines oral health findings associated with unshelled sunflower seed consumption, including characteristic incisal not…
Eating unshelled sunflower seeds may lead to specific wear on front teeth, but researchers say more evidence is needed to prove a direct lin…
Multiomic Integration Prioritizes Guanfacine, Eltrombopag, Encorafenib as Alzheimer Repurposing Candidates
New data identifies specific cell targets in early Alzheimer's disease
This meta-analysis integrates multiomic data to identify cell-type-specific signatures and pharmacological targets in early Alzheimer's dise…
Researchers used advanced data integration to find specific cell types and pathways that could lead to new ways to treat early Alzheimer's d…
Intellectual leadership should define authorship rather than textual production in LLM assisted scientific writing
AI Tools Could Change Who Gets Credit in Science
This perspective piece explores the integration of large language models (LLMs) in scientific writing and publishing. The authors argue that…
A new perspective argues authorship should reward ideas, not just writing, as AI tools reshape scientific publishing.
Genetic variants associated with blood pressure traits in a large admixed population
Large DNA study in Mexico City finds new blood pressure clues
Researchers investigated genetic variants associated with various blood pressure traits in a large cohort of admixed adults. The study ident…
A huge DNA study of people in Mexico City uncovered 13 new genetic signals for blood pressure, plus 6 more in Latin American ancestry.
Natural products like resveratrol and curcumin regulate mitochondrial biogenesis and mitophagy pathways
Natural Products May Help Regulate Cellular Energy and Health
This systematic review examines how natural products, including resveratrol and curcumin, influence mitochondrial homeostasis through the AM…
Natural compounds like resveratrol and curcumin may help regulate mitochondria, the powerhouses of your cells, though some face hurdles in t…
Genetic liability for acute and chronic pancreatitis shows strong correlation and identifies potential drug targets
Genetic links and proteins show shared roots of pancreatitis
This meta-analysis utilizes GWAS, proteome-wide Mendelian randomization, and drug-target Mendelian randomization to identify genetic risk fa…
New research reveals that acute and chronic pancreatitis share strong genetic links and common protein markers that could lead to better tre…
Genetic variants associated with stuttering show significant enrichment in genes linked to speech apraxia
Genetic Research Links Stuttering to Speech and Development Genes
This GWAS meta-analysis of 6,096 cases and 81,629 controls identified no variants reaching genome-wide significance in the primary analysis.…
New genetic research identifies links between stuttering and genes involved in speech and brain development in a large study of over 6,000 c…
Complex interactions between ecological, molecular, and immunological factors drive viral emergence in tropical regions
Complex Factors Drive the Emergence of Tropical Viral Diseases
This narrative review synthesizes the drivers of viral emergence in tropical regions, focusing on ecological, molecular, and immune factors.…
New research highlights how climate change, land use, and viral evolution combine to drive the emergence of tropical viral diseases.
Macrophage pyroptosis drives intestinal inflammation and mucosal barrier impairment in inflammatory bowel disease
Cell death process drives inflammation in inflammatory bowel disease
This systematic review explores the role of macrophage pyroptosis in the pathological evolution of inflammatory bowel disease. The authors c…
A specific type of cell death called macrophage pyroptosis triggers the release of harmful signals that damage the gut lining in inflammator…
eREACH digital intervention meets non-inferiority for genetic service uptake and anxiety in cancer patients
Digital tools may offer an alternative to genetic counselor counseling
This randomized non-inferiority trial of 773 patients found that the eREACH digital intervention was non-inferior to genetic counselor couns…
A new trial shows that digital tools can provide similar results to human counselors when preparing patients for genetic testing.