cfDNA-based NIPT demonstrates high sensitivity and specificity for common fetal trisomies during prenatal screening
Prenatal Blood Test Highly Accurate for Common Trisomies
This systematic review of 20 studies involving more than 67,500 individuals evaluates the diagnostic performance of cfDNA-based NIPT. The an…
A new review finds cell-free DNA prenatal tests are very accurate for Down syndrome, but less so for other conditions.
Printing orientation significantly affects mechanical properties and accuracy of 3D-printed dental prostheses
Printing orientation affects strength and accuracy of 3D dental prostheses
This systematic review of approximately 20 in vitro studies examines how printing orientation impacts the performance of 3D-printed full-cov…
The way a 3D printer positions a dental prosthesis can change its strength and fit, making certain angles better for long-term durability.
Genetic liability for cannabis use is causally linked to increased risk of esophageal and lung cancers
Genetic data reveals link between cannabis use and certain cancers
This meta-analysis using two-sample Mendelian Randomization evaluates the causal link between genetic liability to cannabis use and specific…
New research using genetic markers shows that a person's genetic tendency toward cannabis use may impact risks for lung, esophageal, and pan…
Multi-trait genome-wide association studies identify 66 novel genetic associations in osteoarthritis using the Trident framework
New genetic analysis finds 66 hidden osteoarthritis signals
This meta-analysis evaluates the use of the Trident framework and Combined-GWAS (C-GWAS) method to identify genetic markers for osteoarthrit…
A new genetic method uncovered 66 hidden osteoarthritis signals, offering fresh clues about the condition and potential new targets for trea…
Continuous ancestry representation boosts power in multi-ancestry meta-analysis for type 2 diabetes
New tool improves how researchers study Type 2 Diabetes
This meta-analysis introduces the PANACEA pipeline, which uses a continuous ancestry representation to include participants with outlying an…
A new data method helps scientists better understand the genetic links of Type 2 Diabetes by including a wider range of diverse ancestral ba…
78 plasma proteins linked to psoriasis; 12 prioritized as potential drug targets
78 proteins linked to psoriasis may reveal new drug targets
This meta-analysis of genome-wide association studies (GWAS) identified 78 circulating proteins with genetically predicted associations with…
A large genetic study found 78 proteins tied to psoriasis, including 12 promising drug targets. This could lead to new treatments.
Longitudinal multiomics microbiome analysis methods surveyed in systematic mini-review
New tools to track gut bacteria over time
This systematic mini-review surveys practical methodologies for longitudinal multiomics microbiome data analysis, covering experimental desi…
Scientists map the best ways to study your microbiome over time, which could lead to more personalized health insights.
Pharmacogenomic Guided Therapy Improves Blood Pressure Control and Patient Outcomes in Hypertension
Genetic testing helps patients manage high blood pressure more effectively
Integrating pharmacogenomic testing for specific genes significantly improves blood pressure control and treatment adherence compared to sta…
Using genetic tests to guide blood pressure medication can lead to better control, fewer side effects like dry coughs, and fewer hospital re…
Personalized matching fails to improve eating disorder digital program outcomes
Personalized Treatment Matching Fails to Improve Eating Disorder Outcomes
In this randomized non-inferiority trial of 214 individuals with eating disorder symptoms, using a Personalized Advantage Index to match pat…
A new trial found that matching people with eating disorders to digital programs based on a personalized algorithm did not improve outcomes.
Novel NSF gene variant linked to developmental and epileptic encephalopathy 96 in a fetus
New gene variant linked to rare fetal syndrome
This case report describes a fetus with multiple prenatal anomalies found to carry a novel de novo heterozygous missense variant in the NSF …
A single case reveals a new NSF gene variant tied to severe prenatal anemia and other anomalies, offering a clue for rare fetal syndromes.
Expanded proteomics platform identifies 7,870 pQTLs, 34% novel, in European populations
New data reveals thousands of links between genes and proteins
This meta-analysis of two European cohorts (13,445 participants) using the SomaScan 7k platform identified 7,870 significant pQTLs, of which…
Researchers identified over 7,000 genetic links to blood proteins, uncovering new ways to study disease and find potential treatment targets…
No genetic loci reached genome-wide significance for inpatient opioid exposure after joint arthroplasty
Genetic Research Looks at Opioid Use After Joint Replacement Surgery
This meta-analysis of a genome-wide association study (GWAS) analyzed 27,896 patients undergoing knee or hip arthroplasty to identify geneti…
Researchers analyzed the genetic data of over 27,000 patients to see if specific genes predict how much opioid medication a person needs aft…