Meta-analysis identifies protein associations with behavioral symptoms in dementia
New Brain Clues Explain Dementia Mood Symptoms
This meta-analysis of brain proteomic profiles from 376 donors synthesized associations between specific proteins and behavioral and psychol…
Anxiety and mood swings in dementia may stem from specific brain proteins, offering real hope for future treatments that target the root cau…
Case report identifies novel CLMN::SYNE3 chimeric transcript in SCA30 family
A Gene Fusion Is Causing A Rare Ataxia In One Family
This research article reports a genetic analysis of a family with spinocerebellar ataxia. It identifies a 331 kb duplication leading to a ch…
A gene mix-up that creates a faulty protein is the likely cause of a rare, inherited movement disorder in one family, opening a path to a pr…
Systematic review maps stay-green trait research trends in legumes from 1993 to 2025.
How Plants That Stay Green Longer Could Change What We Eat
This systematic review and bibliometric analysis of 157 articles on stay-green biology in legumes identifies a steady rise in publications a…
Some plants refuse to turn yellow and die when they should.
Retrospective analysis shows PGT for structural rearrangements yields different euploid rates compared to PGT-A or PGT-PV groups.
Chromosome Flip Doesn't Always Mean Bad Eggs
This retrospective analysis evaluated couples undergoing preimplantation genetic testing (PGT) for structural rearrangements between January…
A specific type of chromosome change does not lower your chances of having a healthy baby, but the size of the change and which parent carri…
Multi-ancestry meta-analysis identifies X-chromosome loci for heart failure phenotypes
Hidden Heart Failure Risk Found on X Chromosome
This multi-ancestry meta-analysis of the Million Veteran Program and UK Biobank sought X-chromosome loci associated with heart failure. Inve…
A new study reveals hidden genetic factors on the X chromosome that may influence heart failure risk.
Meta-analysis identifies 3,207 novel DNA methylation sites linked to smoking
New DNA markers reveal how smoking changes your genes across many backgrounds
This meta-analysis of 45,460 individuals from the Million Veteran Program identified 3,207 novel probe-smoking associations in DNA methylati…
A massive new study shows smoking alters your DNA in thousands of ways, but these changes are not yet tools for doctors to use.
Multi-ancestral GWAS identifies 152 RA loci with improved polygenic risk scores for AFR and AMR populations.
New genetic clues for rheumatoid arthritis found in diverse veteran populations
This cohort study utilized the Million Veteran Program (MVP) to perform multi-ancestral GWAS with multimodal automated phenotyping for rheum…
Scientists identified new genetic markers for rheumatoid arthritis in diverse groups, improving risk prediction especially for African Ameri…
Geneticist involvement correlates with higher testing uptake and diagnostic yield in perinatal demise cases.
Geneticist Involvement Linked to Better Outcomes in Perinatal Demise Cases
This cohort study of 111 perinatal demise cases observed that geneticist involvement was associated with significant increases in testing up…
A cohort study of 111 cases found that involving a geneticist increased testing uptake, diagnostic yield, and patient education while reduci…
Review of Swedish SCAD patients notes modest actionable variant yield in exome sequencing data.
SCAD Heart Attacks in Women Often Start With Rare Genes
This observational review synthesizes data from 201 Swedish patients with spontaneous coronary artery dissection (SCAD) within the SweSCAD n…
Nearly 60% of women with SCAD heart attacks carry rare gene variants linked to vessel strength, reshaping how doctors view this condition.
Observational Study Links Latitude and Genetics to Seasonal Affective Disorder Risk in Adults
Winter Blues Tied to Genes and Where You Live
This primary research article analyzes data from 12,460 adults in the Australian Genetics of Depression Study. Researchers found latitude po…
Where you live and the genes you carry may shape how much winter drags down your mood — and it’s not just about sunlight.
Narrative review proposes framework for TWAS signature-matching in drug prioritization
New method finds better drug targets using your DNA data
This narrative review and framework proposal examines the TWAS signature-matching approach with varying parameters, including TWAS method, e…
A new gene-based method can point doctors to better drugs, but the right settings are critical for accuracy.
Commentary on CalPred calibration performance versus PredInterval in trait prediction
Better Risk Scores Need Honest Uncertainty Ranges
This commentary reviews the performance of CalPred for calibration of prediction intervals, contrasting it with PredInterval. The authors sy…
Imagine getting a weather forecast that says there is a 90% chance of rain.