Meta-analysis links BMI polygenic scores to BMI in Filipino youth with double burden of malnutrition
Your Genes Affect Weight Differently If You're a Boy or Girl
This meta-analysis of cross-sectional data examined associations between BMI-related polygenic scores (PGSs) and anthropometric measures in …
• Genetic scores predict body fat better in Filipino boys than girls • Helps doctors understand childhood malnutrition in vulnerable communi…
Systematic Review Finds Circulating miRNAs Show High Diagnostic Accuracy for Breast Cancer
Blood Test May Catch Breast Cancer Earlier Than Mammograms
This systematic review examined blood-derived miRNAs for diagnosing breast cancer. The analysis found high diagnostic accuracy (AUC > 0.9) i…
A new blood test could spot early breast cancer with high accuracy, especially for women with dense breasts where mammograms often miss tumo…
Meta-analysis of GWAS in Native Hawaiians and Polynesians identifies 25 trait loci for diabetes and obesity traits
Genome scans in Native Hawaiians and Polynesians reveal 25 genetic links to diabetes traits
This meta-analysis review synthesized genome-wide association studies in Native Hawaiians and Polynesian-ancestry populations. It identified…
A large genetic analysis found 25 confirmed links between DNA variants and traits like blood sugar in Native Hawaiian and Polynesian populat…
Mitochondrial engineering enhances CAR-T cell therapy for solid and blood cancers
New cell therapy upgrade helps immune cells survive longer in tumors
A mini-review explores mitochondrial engineering strategies to boost CAR-T cell efficacy against solid and hematological malignancies, highl…
A new approach to engineering immune cells could solve a major problem: why they stop working inside solid tumors.
Genotype-Guided SSRI Prescribing Shows No Short-Term Benefit but Higher Remission at 6 Months
Genetic Testing Helps Some Depression Patients Feel Better Long Term
This randomized clinical trial compared genotype-guided SSRI prescribing to usual care in 1460 patients with depression. At 3 months, there …
• Genetic-guided SSRI prescriptions boost six-month remission rates for certain patients • Helps people with specific gene variations affect…
Meta-analysis identifies new genetic loci for Alzheimer disease across diverse veteran populations
New Alzheimer’s Genes Found in Veterans Study Unlock Fresh Treatment Paths
This meta-analysis of genetic data from the VA Million Veterans Program evaluated Alzheimer disease and related dementias in European, Hispa…
A massive study of US Veterans uncovered 26 new gene regions tied to dementia, pointing to fresh targets for future treatments.
Meta-analysis of preclinical models shows enhanced outcomes for focused ultrasound gene therapy in glioblastoma
Ultrasound Opens a New Door for Brain Cancer Treatment
This systematic review and meta-analysis evaluated focused ultrasound mediated gene therapy in preclinical orthotopic glioblastoma in vivo m…
A new review of nine studies shows that focused ultrasound can safely deliver gene therapy across the brain's protective barrier, shrinking …
1-Hz TMS targeting right dlPFC reduced amygdala reactivity and PTSD symptoms in 50 adults with PTSD symptoms compared with sham
Personalized Brain Stimulation Shows Promise For Long Term PTSD Relief
This randomized clinical trial enrolled 50 adults with PTSD symptoms.
Brain scans guide magnetic pulses to reduce fear responses in PTSD patients over several months of recovery time.
Personalized medication regimens improved blood pressure control in 776 hypertensive outpatients over eight weeks
Personalized drug plans may lower uncontrolled blood pressure risk in hypertension patients
This multicenter, single-blind, prospective, randomized controlled trial enrolled 776 hypertensive outpatients across eight hospitals.
A trial of 776 patients found personalized medication plans based on genetics improved blood pressure control and reduced drug use.
Review of X chromosome inactivation in women with pathogenic variants and cancer risk
Women with X-linked cancer risks face unique genetic challenges
This narrative review examines X chromosome inactivation and its implications for women carrying pathogenic variants on the X chromosome.
A review explores how X chromosome inactivation affects women carrying pathogenic variants linked to cancer and X-linked syndromes.
Genomically tailored multiagent regimen shows limited efficacy in recurrent glioblastoma
Personalized drug combos extend life in brain cancer
This phase I trial tested a genomically tailored multiagent regimen in 30 adults with recurrent glioblastoma. Median overall survival was 12…
A new approach using tailored drug combinations is helping some patients with recurring brain cancer live longer, offering fresh hope where …
Qualitative review finds governance gaps limit feasibility of lifelong genomic medicine in US health systems
Lifelong genomic medicine faces governance gaps, experts say
This qualitative review synthesizes perspectives from over 50 US-based healthcare professionals regarding lifelong genomic medicine.
Healthcare experts endorse lifelong genomic medicine but say governance gaps in consent, data stewardship, and recontact limit its feasibili…