CircRNAs act as signaling hubs for immune checkpoints and indicators of ICI response in lymphoma
CircRNAs May Help Predict Response to Lymphoma Immunotherapy
This systematic review examines the role of circRNAs, including EBV-encoded types, in immune evasion within lymphomas. The authors conclude …
New research suggests that specific molecules called circRNAs could help doctors predict how patients with lymphoma will respond to immune c…
Genomic selection using SNP chips provides accurate breeding value predictions for goat production traits
Genomic selection improves accuracy for breeding goats with specific traits
This mini review synthesizes evidence on the use of SNP chips and genomic selection in goat breeding compared to traditional pedigree-based …
New genetic tools allow goat breeders to identify the best animals for milk, growth, and fiber quality much earlier than traditional methods…
Mechanical stress drives metabolic reprogramming and stromal remodeling in the bladder cancer microenvironment
Mechanical stress drives cancer growth and drug resistance in bladder cancer
This systematic review examines how mechanical stresses like ECM stiffening and fluid shear stress influence the bladder cancer microenviron…
Physical pressure on tissues can change how bladder cancer cells behave, making them harder to treat with standard therapies.
SHOX gene deficiency causes Langer mesomelic dysplasia with severe disproportionate short stature and limb hypoplasia
SHOX Gene Deficiency Linked to Specific Skeletal Growth Disorders
This narrative review explores the molecular basis of Langer mesomelic dysplasia caused by SHOX gene deficiency. The authors synthesize find…
A review of the SHOX gene shows how its deficiency leads to specific limb shortening and short stature in certain conditions.
Gene editing in Africa needs a phased, harmonized continental governance framework
New Framework Proposes Unified Gene Editing Governance for Africa
This policy review synthesizes evidence and normative arguments to propose a phased, harmonized continental governance framework for gene ed…
A new proposed framework aims to unify fragmented gene editing rules across Africa by balancing modern science with local cultural values.
Molecular drivers including DNA damage response and epigenetics contribute to treatment resistance in HPV-positive OPSCC
Understanding the Molecular Causes of Treatment Resistance in Throat Cancer
This systematic review examines the molecular architecture of treatment resistance in patients with HPV-positive oropharyngeal squamous cell…
Doctors are looking into why some throat cancers do not respond to standard treatments like radiation and chemotherapy.
SUZ12 variant identified as a genetic cause of overgrowth phenotype and spinal stenosis
Genetic variant linked to spine issues in overgrowth syndrome
This case report with systematic literature review describes an 11-year-old girl with Imagawa-Matsumoto syndrome (IMMAS) and cervical spinal…
A rare genetic mutation was found causing spinal cord compression in a child with an overgrowth condition.
Epigenetic regulation provides a framework for understanding disease heterogeneity and potential precision therapies in osteoarthritis
Epigenetic changes provide a new way to understand osteoarthritis
This systematic review explores the role of epigenetic regulations, including DNA methylation and histone modifications, in the pathogenesis…
New research highlights how chemical changes to DNA could help doctors better understand and treat the complex causes of osteoarthritis.
MicroRNAs influence lipid metabolism, inflammation, and fibrosis in nonalcoholic steatohepatitis progression
Small molecules called microRNAs may help track and treat liver disease
This systematic review examines the role of microRNAs (miRNAs) in the pathophysiology of nonalcoholic fatty liver disease. The authors synth…
New research highlights how tiny molecules called microRNAs influence liver inflammation and scarring, offering hope for better diagnosis an…
818 consensus loci identify distinct neurodevelopmental, synaptic, and metabolic pathways in schizophrenia and bipolar disorder
Genetic map reveals why schizophrenia and bipolar disorder affect thinking differently
This meta-analysis identifies 818 consensus genetic loci associated with cognitive divergence in schizophrenia and bipolar disorder. The stu…
New genetic map reveals 818 loci linked to schizophrenia and bipolar disorder, showing why thinking skills vary. Some genes raise risk but b…
Multimodal gene prioritization improves predictive performance of polygenic transcriptome risk scores for asthma
New Genetic Framework Identifies Risk Factors for Childhood Asthma
This meta-analysis evaluates a multimodal gene prioritization framework integrating GWAS, bulk tissue eQTL, and single-cell gene eQTL data t…
A large study identifies 275 genetic locations linked to asthma, helping researchers better understand how genes influence the risk of devel…
GWAS meta-analysis identifies 44 TIA loci, 19 specific to transient ischemic attack
Genetic study identifies new targets for stroke and mini-strokes
This meta-analysis of genome-wide association studies across European, non-European, and multi-ancestry individuals identified 44 loci assoc…
A massive genetic study of over 1.9 million people has identified specific genes that may help doctors target the causes of strokes and TIA.