GLP1R locus variants associated with higher BMI and Type 2 Diabetes risk in genetically inferred European ancestry participants.
Do your genes make you heavier? New data suggests specific gene variants are linked to higher body weight.
This genetic association study analyzed 431,107 participants from the Million Veteran Program to evaluate GLP1R locus variants rs12213929 an…
Two specific gene variants linked to higher body weight also influence Type 2 diabetes risk, though one marker's connection to diabetes disa…
Sex-stratified multi-omic integration identifies specific molecular candidates and pathways in Parkinsons disease.
Why Men and Women Get Parkinson's Differently
This multi-omic integration study analyzed data from over 70,000 participants with Parkinsons disease and controls to identify sex-specific …
Men and women develop Parkinson's differently, with specific proteins driving the disease in each sex rather than a single cause for everyon…
GWAS identifies six genetic loci associated with Tourette syndrome in European ancestry populations.
Study finds genetic links between Tourette Syndrome and other brain conditions in a large group
This genome-wide association study analyzed 13,247 cases and 536,217 controls of European ancestry to identify genetic risk factors for Tour…
Tourette Syndrome shares specific genetic links with ADHD and other brain conditions, pinpointing 20 genes tied to dopamine neurons and brai…
Genomic and functional analyses address missing heritability in HDGC-like families lacking CDH1 and CTNNA1 variants.
Why Some Stomach Cancer Families Were Missing a Genetic Answer All Along
This cohort study analyzed 19 HDGC-like probands and six additional families to investigate mechanisms of hereditary diffuse gastric cancer …
A new genetic study found missing causes of hereditary stomach cancer in nearly half of families who had previously tested negative.
Computational platform expands genetic screening scope in high-consanguinity Gulf populations
Could a new genetic screening tool prevent thousands of inherited diseases?
A computational platform description and economic modeling study in Saudi Arabia and Gulf Cooperation Council States projects that expanding…
A new screening tool could prevent 2,800 to 4,200 births of children with inherited diseases each year by expanding checks from two to over …
Epigenome-wide study identifies methylation differences in monozygotic and dizygotic twins discordant for nonsyndromic cleft lip with or without cleft palate.
Twin study finds DNA marks linked to cleft lip and palate
This epigenome-wide association study examined 32 monozygotic and 22 dizygotic twin pairs discordant for nonsyndromic cleft lip with or with…
A twin study found specific DNA marks linked to cleft lip and palate, pointing to chemical tags that influence how genes work during facial …
Melanoma cell subpopulations identified; EIF5A linked to poor outcomes in observational cohort.
New Cell Types Found That Help Fight Melanoma
This observational study analyzed 70,760 cells from 11 samples and clinical specimens from seven patients, alongside the TCGA-SKCM cohort. R…
Some melanoma cells help your immune system fight the cancer, and a new study identifies seven major cell types linked to better outcomes.
Reni-cel gene therapy shows transfusion independence in small phase 1-2 trial for β-thalassemia
New Gene Edit Stops Blood Transfusions
A single-group phase 1-2 trial in 9 adults with transfusion-dependent β-thalassemia found all participants achieved neutrophil engraftment a…
A new gene edit reactivates natural red blood cell production, potentially ending the need for lifelong transfusions in adults with severe b…
Methodological analysis reveals biases in heritability estimates from ultra-rare variants in UK Biobank data.
Tiny DNA Changes May Shape Your Health
This methodological analysis examined 305,813 unrelated European-ancestry individuals in the UK Biobank to assess biases in estimating herit…
Tiny DNA spelling mistakes once thought too rare to matter actually shape your health, but standard math tools often create false signals ab…
Genetic correlation between kidney function and Alzheimer disease is absent in European and African ancestry cohorts.
Why Kidneys and the Aging Brain May Share More DNA Than We Knew
This cohort study examined shared genetic architecture between kidney function and Alzheimer disease in European and African ancestry indivi…
Kidney disease patients face higher Alzheimer's risk because specific genes link the two conditions, with the famous APOE gene playing a key…
Mexican cohort study reports allele frequencies for six obesity-associated genetic variants
Your Genes May Explain Why Weight Loss Feels So Hard
A cohort study of 129 individuals from Mexico City measured allele frequencies for six obesity-associated single nucleotide variants. The SH…
Six specific obesity-linked genes in a Mexican population help explain why some bodies store fat more easily than others, mapped for the fir…
Review analyzes genome editing innovations for plant biotechnology and crop improvement
How are scientists making plant gene editing more precise?
This systematic review critically analyzes recent developments in genome editing technologies (CRISPR/Cas9, base editing, prime editing) for…
New editing tools like prime editing are making it easier to insert helpful genes into crops with greater precision and control.