Meta-analysis of ABCD Study data links genetic variants to timing of substance use initiation in adolescents
Your Teen's DNA May Shape When They First Try Drugs
This meta-analysis examined longitudinal data from the Adolescent Brain Cognitive Development (ABCD) Study across European, African, and His…
A teen's genes may influence when they first try alcohol, nicotine, or cannabis, not just whether they do, with earlier use linked to higher…
APOE epsilon4 allele frequencies vary widely across Indian populations with implications for dementia risk assessment
A Single Gene Could Change How India Screens for Alzheimer's
This observational study analyzed APOE epsilon4 allele frequencies in 9,524 individuals from the GenomeIndia dataset representing diverse In…
Alzheimer's risk in India varies wildly by region, with some tribal groups facing much higher genetic danger than others, demanding new scre…
Mendelian randomization suggests loneliness causally increases schizophrenia and major depressive disorder risk
Feeling Alone May Quietly Rewire Your Mental Health
This Mendelian randomization study investigated the causal relationship between loneliness and severe mental illness, including schizophreni…
Loneliness may directly raise the risk of schizophrenia and depression by changing body chemistry through inflammation, affecting millions o…
LDeconv method reduces false discoveries and preserves true associations in UK Biobank data analysis
New Math Trick Could Make Genetic Studies Far More Accurate
This methodological study evaluated the LDeconv method within the UK Biobank cohort.
A new math trick filters out false signals in genetic studies, helping scientists find the real genes behind common diseases like diabetes a…
Detection of TP53 variants distinguishes germline and somatic clonal expansions with associated cancer risk in UK Biobank participants
Hidden Blood Mutations Rewrite Cancer Risk Rules For Millions
This observational analysis of UK Biobank data examined TP53 variants to distinguish germline from somatic clonal expansions and assess asso…
Many scary cancer gene findings in blood tests are not inherited but acquired later in life, changing how doctors assess risk for millions.
Cross-trait analyses reveal complex genetic overlaps between cortical morphology and psychiatric disorders
Your Brain's Blueprint May Not Predict Mental Illness After All
This cross-trait analysis examined genetic loci shared between cortical surface area or thickness and various psychiatric conditions.
Brain shape genes and mental illness genes often push in opposite directions, complicating hopes for using scans and DNA to predict conditio…
Observational study finds no association between ZFHX3 GGC repeat expansions and ALS risk
New DNA Scan Rules Out ALS Link
This observational research article examined ZFHX3 GGC repeat expansions in 5,785 people with ALS and 7,982 healthy controls.
A major genetic test confirms that a specific repeat in your DNA does not cause ALS, even though it can cause a different movement disorder.
Whole-genome sequencing reveals variant enrichment patterns in Emirati inherited retinal disease cohorts
Genomic study finds many inherited eye disease variants are common in Emirati population
This cohort study analyzed 504,000 participants from the Emirati Genome Program to assess pathogenicity reassessment and novel variant disco…
Researchers analyzed whole-genome data from 504,000 Emirati participants to better understand inherited retinal diseases.
Whole-genome sequencing of fathers with children with developmental disorders shows sperm mutation burden indistinguishable from controls
Why Fathers' Sperm Isn't Always To Blame
This cohort study examined fathers of children with developmental disorders and population reference cohorts using whole-genome and ultra-ac…
Most new genetic mutations causing developmental disorders come from normal aging rather than a specific flaw in a father's sperm.
GLP1R locus variants associated with higher BMI and Type 2 Diabetes risk in genetically inferred European ancestry participants
Do your genes make you heavier? New data suggests specific gene variants are linked to higher body weight
This genetic association study analyzed 431,107 participants from the Million Veteran Program to evaluate GLP1R locus variants rs12213929 an…
Two specific gene variants linked to higher body weight also influence Type 2 diabetes risk, though one marker's connection to diabetes disa…
Sex-stratified multi-omic integration identifies specific molecular candidates and pathways in Parkinsons disease
Why Men and Women Get Parkinson's Differently
This multi-omic integration study analyzed data from over 70,000 participants with Parkinsons disease and controls to identify sex-specific …
Men and women develop Parkinson's differently, with specific proteins driving the disease in each sex rather than a single cause for everyon…
GWAS identifies six genetic loci associated with Tourette syndrome in European ancestry populations
Study finds genetic links between Tourette Syndrome and other brain conditions in a large group
This genome-wide association study analyzed 13,247 cases and 536,217 controls of European ancestry to identify genetic risk factors for Tour…
Tourette Syndrome shares specific genetic links with ADHD and other brain conditions, pinpointing 20 genes tied to dopamine neurons and brai…