Genotype-Guided SSRI Prescribing Shows No Short-Term Benefit but Higher Remission at 6 Months
Genetic Testing Helps Some Depression Patients Feel Better Long Term
This randomized clinical trial compared genotype-guided SSRI prescribing to usual care in 1460 patients with depression. At 3 months, there …
• Genetic-guided SSRI prescriptions boost six-month remission rates for certain patients • Helps people with specific gene variations affect…
Meta-analysis identifies new genetic loci for Alzheimer disease across diverse veteran populations
New Alzheimer’s Genes Found in Veterans Study Unlock Fresh Treatment Paths
This meta-analysis of genetic data from the VA Million Veterans Program evaluated Alzheimer disease and related dementias in European, Hispa…
A massive study of US Veterans uncovered 26 new gene regions tied to dementia, pointing to fresh targets for future treatments.
Meta-analysis of preclinical models shows enhanced outcomes for focused ultrasound gene therapy in glioblastoma
Ultrasound Opens a New Door for Brain Cancer Treatment
This systematic review and meta-analysis evaluated focused ultrasound mediated gene therapy in preclinical orthotopic glioblastoma in vivo m…
A new review of nine studies shows that focused ultrasound can safely deliver gene therapy across the brain's protective barrier, shrinking …
Personalized medication regimens improved blood pressure control in 776 hypertensive outpatients over eight weeks
Personalized drug plans may lower uncontrolled blood pressure risk in hypertension patients
This multicenter, single-blind, prospective, randomized controlled trial enrolled 776 hypertensive outpatients across eight hospitals.
A trial of 776 patients found personalized medication plans based on genetics improved blood pressure control and reduced drug use.
1-Hz TMS targeting right dlPFC reduced amygdala reactivity and PTSD symptoms in 50 adults with PTSD symptoms compared with sham
Personalized Brain Stimulation Shows Promise For Long Term PTSD Relief
This randomized clinical trial enrolled 50 adults with PTSD symptoms.
Brain scans guide magnetic pulses to reduce fear responses in PTSD patients over several months of recovery time.
Review of X chromosome inactivation in women with pathogenic variants and cancer risk
Women with X-linked cancer risks face unique genetic challenges
This narrative review examines X chromosome inactivation and its implications for women carrying pathogenic variants on the X chromosome.
A review explores how X chromosome inactivation affects women carrying pathogenic variants linked to cancer and X-linked syndromes.
Genomically tailored multiagent regimen shows limited efficacy in recurrent glioblastoma
Personalized drug combos extend life in brain cancer
This phase I trial tested a genomically tailored multiagent regimen in 30 adults with recurrent glioblastoma. Median overall survival was 12…
A new approach using tailored drug combinations is helping some patients with recurring brain cancer live longer, offering fresh hope where …
Qualitative review finds governance gaps limit feasibility of lifelong genomic medicine in US health systems
Lifelong genomic medicine faces governance gaps, experts say
This qualitative review synthesizes perspectives from over 50 US-based healthcare professionals regarding lifelong genomic medicine.
Healthcare experts endorse lifelong genomic medicine but say governance gaps in consent, data stewardship, and recontact limit its feasibili…
Meta-analysis identifies ancestry-specific and shared genetic loci for restless legs syndrome in diverse populations
Genetic study finds new risk factors for restless legs syndrome in diverse populations
This meta-analysis examines genome-wide association data from biobank-based cohorts involving African, Latin American, and European ancestry…
A large genetic study reveals new risk factors for restless legs syndrome in African, Latin American, and European ancestry groups.
TNFAIP3 variants show estimated prevalence of 1:2,800 in U.S. autoimmune disease cohorts
A hidden genetic cause of autoimmune disease is more common than doctors thought
This cohort study estimated the prevalence of TNFAIP3 loss-of-function and haploprotein-missing variants in U.S.
A specific gene variant linked to autoimmune disease is found in about one in 2,800 people in the U.S.
Sex differences in genetic correlation between ischaemic heart disease and depression found in 1.14 million European ancestry individuals
Genetic links between heart disease and depression are twice as strong in women
This review analysis of summary statistics from a sex-stratified genome-wide association study involving 1.14 million European ancestry indi…
Genetic links between heart disease and depression are twice as strong in women. This analysis of 1.14 million people shows why sex matters …
CRISPR SGE platform maps functional impact of 470 IL2RG variants in X-linked severe combined immunodeficiency
New tool maps genetic errors that break immune system cells
This article describes a CRISPR-targeted saturation genome editing (SGE) platform used to map functional impact of variants in X-linked seve…
A new method mapped 470 genetic changes in immune cells, confirming 90 that stop the cells from working properly.