Metagenomic next-generation sequencing shows higher sensitivity than conventional tests for pediatric infectious disease diagnosis.
New test may help find infections in children but has limits
This systematic literature review and meta-analysis evaluated diagnostic accuracy in pediatric patients (≤21 years) with suspected infectiou…
A new test finds infections in sick children 84% of the time, nearly doubling the success rate of standard lab tests that only catch them 40…
Enhanced peer PrEP referral with HIV self-testing did not increase PrEP initiation but increased HIV testing among Kenyan AGYW.
Enhanced peer referral increased HIV testing but did not boost PrEP use among Kenyan young women
This randomized controlled trial evaluated enhanced peer referral strategies versus standard referral among adolescent girls and young women…
Enhanced peer referrals boosted HIV testing among Kenyan young women but did not increase PrEP use compared to standard methods.
Antibiotic therapy versus appendectomy showed no difference in one-year complication rates for adults with imaging-confirmed acute appendicitis.
Is taking antibiotics or surgery better for your appendix, and what does the data really show?
This meta-analysis of individual patient data from randomized controlled trials included 2,101 adults with imaging-confirmed acute appendici…
Choosing antibiotics over surgery for your appendix carries similar risks for most, but a specific stone makes complications much more likel…
Meta-analysis shows HIV prevalence is 50% higher in transgender women than cis-MSM in sub-Saharan Africa.
HIV prevalence was higher among transgender women than cisgender men in sub-Saharan Africa
This meta-analysis pooled data from 21 observational studies conducted between 2010 and 2022 in sub-Saharan Africa, involving 8,476 transgen…
HIV is 50% more common among transgender women than cisgender men in sub-Saharan Africa, with rates closely tracking those of men who have s…
Review explores ferroptosis mechanisms in host cell damage during diverse pathogen infections
Review explores how a cell death process called ferroptosis relates to infections
A systematic review summarizes existing research on ferroptosis—a form of cell death—during infections by viruses, bacteria, fungi, and para…
A cell death process called ferroptosis may damage host cells during infections by viruses, bacteria, fungi, and parasites, potentially affe…
Single Preoperative Antibiotic Dose vs Week-Long Postoperative Course for SSI Prevention in TE Breast Reconstruction
Is one antibiotic dose enough to prevent infection after breast reconstruction?
A multi-institutional RCT of 214 women undergoing immediate tissue expander breast reconstruction compared a single preoperative antibiotic …
A single antibiotic dose before breast reconstruction led to a 17% infection rate, compared to 11% with a week of pills, but the study didn'…
Review synthesizes fungal immune evasion mechanisms and emerging immunotherapies for invasive fungal infections
Review explores how fungi evade immune systems and potential new treatment approaches
A narrative review synthesizes advances in understanding immune evasion by major fungal pathogens and immune dysregulation in immunocompromi…
Fungi like Candida and Aspergillus evade the immune system by hiding or forming biofilms, but new treatments could combine antifungal drugs …
Systematic review finds probiotics and prebiotics improve health outcomes in aquaculture species
Review finds probiotics and prebiotics may benefit farmed fish health and growth
A systematic and bibliometric review of existing literature on aquaculture found that probiotics and prebiotics as feed additives have posit…
A review of over 1,400 studies suggests probiotics and prebiotics can boost farmed fish immunity, disease resistance, and growth as antibiot…
Meta-analysis finds topical propolis/honey associated with faster herpes lesion resolution than acyclovir
Topical propolis and honey may help heal herpes lesions faster than acyclovir cream
A meta-analysis of 7 studies compared topical propolis and/or honey to 5% topical acyclovir for labial and genital herpes lesions. Propolis/…
Using natural propolis or honey on herpes sores healed lesions nearly two days faster and cut pain compared to standard acyclovir cream.
Systematic review identifies recurrent fungal and bacterial genera in indoor environments across Gulf Cooperation Council countries.
Do your Gulf homes hide dangerous mold and bacteria in the dust and air?
This systematic review examined indoor microbial contamination in residential, commercial, educational, and healthcare buildings across the …
Invisible germs like Aspergillus and Staphylococcus thrive in Gulf dust and damp walls, creating real infectious risks in homes and offices …
Systematic review indicates diverse viruses exploit host peptidylarginine deiminase isoforms to subvert immunity and enhance replication.
Viruses are evolving to hijack your body's own enzymes to hide from your immune system.
This systematic review examined the roles of peptidylarginine deiminase (PAD) and protein citrullination in viral infections. Evidence sugge…
Viruses hijack your body's own enzymes to hide from your immune system and multiply quickly before you even know you are sick.
Three patients arrived at emergency department after snorting powder thought to be cocaine
What happens when cocaine is actually fentanyl? Three people found out.
A case report describes three patients who presented to a California emergency department after snorting white powder they believed to be co…
Three people thought they snorted cocaine, but the white powder was actually fentanyl that put their lives in immediate danger.