One-stage revision shows comparable infection control to two-stage revision in chronic periprosthetic joint infection
One Surgery Could Fix Your Joint Infection
This retrospective cohort study evaluated chronic periprosthetic joint infection (PJI) patients undergoing one-stage versus two-stage revisi…
One surgery for joint infections works as well as the standard two-stage process, letting patients recover faster without the long wait.
Pooled Xpert MTB/RIF Ultra testing shows high specificity but reduced sensitivity compared to individual testing in Vietnamese adults with presumptive tuberculosis
Could testing TB samples in groups save money while still catching most cases?
This cross-sectional study evaluated pooled versus individual Xpert MTB/RIF Ultra testing among 2,396 adults with presumptive tuberculosis i…
Testing tuberculosis samples in groups saved over $14,000 and cut test kit use by nearly half while still catching most infections.
In Haiti, mosquito exposure linked to elevated IgG antibodies against specific salivary peptides in a low-transmission setting
Mosquito Spit Is Becoming a Malaria Early Warning
This observational study enrolled 348 participants in Grand Anse, Haiti, to assess immune responses to Anopheles salivary peptides.
A simple blood test now reveals how often people in Haiti have been bitten by malaria mosquitoes, helping health workers track invisible dis…
Antibiotic-resistant E. coli found on Welsh meat shows links to sheep but not human infections
Your Dinner Meat May Carry Resistant Germs. Should You Worry?
This observational study assessed antibiotic-resistant Escherichia coli on beef and lamb steaks purchased from independent butchers in Wales…
A Welsh study found antibiotic-resistant germs on butcher meat, but the bugs rarely matched those causing human infections, suggesting limit…
KP ST258 Clade 2 isolates linked to increased virulence in observational and mouse studies
Klebsiella Clade 2 Linked to Worse Illness in Humans and Mice
An observational study of 172 clinical KP ST258 isolates and a mouse model found that Clade 2 isolates were associated with more acute illne…
Klebsiella pneumoniae Clade 2 causes worse illness in humans and spreads more easily to organs like the liver and spleen in mice compared to…
FDA Approves Fosfomycin Tromethamine (fosfomycin tromethamine) for Uncomplicated Urinary Tract Infections in Women
FDA approves new single-dose antibiotic for treating bladder infections in women
Fosfomycin tromethamine granules for oral solution was approved for uncomplicated urinary tract infections (acute cystitis) in women due to …
FDA approves a new single-dose antibiotic for women with bladder infections, offering a convenient one-time treatment option for common urin…
Phase 3 trial of Ad5-nCoV vaccine shows no increased short-term HIV infection risk in 44,247 participants
Ad5 COVID Vaccine Cleared of HIV Risk in 44,247-Person Trial
This Phase 3 randomized controlled trial evaluated the association between the Ad5-nCoV vaccine and HIV infection risk in 44,247 HIV-negativ…
A decades-old worry that certain vaccine delivery systems might raise HIV risk does not apply to the Ad5 COVID vaccine, based on a trial of …
Pitavastatin showed no difference in health-related quality of life compared with placebo in people with HIV
Why Heart Risk Factors Drag Down Daily Wellbeing for People With HIV
This randomized controlled trial evaluated pitavastatin versus placebo in 733 people with HIV aged 40 to 75 years on antiretroviral therapy …
Common heart risks like smoking and high BMI hurt daily physical wellbeing for people with HIV, while statins showed no visible improvement …
ALIS plus macrolide regimen improves culture conversion in noncavitary MAC lung disease
An Inhaled Antibiotic Shifts the Odds in a Stealthy Lung Infection
In a 99-patient RCT of adults with noncavitary MAC lung disease, adding 6 months of amikacin liposome inhalation suspension (ALIS) to a macr…
Adding a nebulized antibiotic to standard pills helped more newly diagnosed MAC lung patients clear the bug sooner, with no new safety surpr…
Meta-analysis finds 9% Shigella prevalence across human, animal, food, and environmental samples in Cameroon
Why a Common Diarrhea Bug in Cameroon Is Outsmarting First-Line Antibiotics
A systematic review and meta-analysis of 24,847 samples from Cameroon found an overall pooled Shigella prevalence of 9% (95% CI, 5.51%-14.76…
A Cameroon-wide review found Shigella infections cause about 6% of human diarrhea cases — and that the bacteria are increasingly resistant t…
DOACs reduce thromboembolic events in pediatric patients compared to standard anticoagulation
A Pill Form of Blood Thinner May Be Safer for Kids Than Standard Shots
A meta-analysis of 2,002 pediatric patients found direct oral anticoagulants (DOACs) significantly reduced thromboembolic event recurrence (…
New oral blood thinners cut dangerous blood clot recurrences in half for children without increasing bleeding risks compared to standard sho…
BV100 (rifabutin for infusion) showed dose-proportional pharmacokinetics and safety in healthy volunteers
A New IV Drug Targets the Hardest Hospital Infections to Treat
This Phase 1 randomized controlled trial evaluated the pharmacokinetics, safety, and tolerability of BV100 (rifabutin for infusion) in healt…
A reformulated intravenous version of the antibiotic rifabutin appears safe in healthy volunteers and may give doctors a new tool for treati…